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Low expression of the interleukin (IL)-4 receptor alpha chain and reduced signalling via the IL-4 receptor complex in human neonatal B cells.
Tian C, Kron GK, Dischert KM, Higginbotham JN, Crowe JE
(2006) Immunology 119: 54-62
MeSH Terms: Adult, Analysis of Variance, Apoptosis, B-Lymphocytes, Cell Separation, Fetal Blood, Flow Cytometry, Gene Expression, Humans, Infant, Newborn, Interleukin-13, Interleukin-13 Receptor alpha1 Subunit, Interleukin-4, Interleukin-4 Receptor alpha Subunit, Phosphorylation, Reverse Transcriptase Polymerase Chain Reaction, STAT6 Transcription Factor, Signal Transduction
Show Abstract · Added August 6, 2012
Diminished neonatal antibody responses following infection or immunization may stem in part from intrinsic characteristics of neonatal B cells. In this study, we used B-cell subset sorting combined with gene expression assays to investigate major differences in the expression of host genes in neonatal and adult naïve B cells. We discovered significantly reduced expression of the interleukin (IL)-4 receptor alpha chain and reduced IL-4-induced signalling in neonatal B cells. Neonatal naïve B cells were susceptible to more rapid and more profound levels of apoptosis when cultured in vitro. They also exhibited a limited response to IL-4 treatment compared with adult cells. The expression level of the IL-13 receptor alpha 1 chain, a key component of the IL-13 receptor/IL-4 type II receptor, and the response to IL-13 treatment for protection against apoptosis in neonatal B cells were similar to those of the adult B cells. These studies suggest a possible mechanism underlying the limited magnitude and durability of neonatal antibody responses.
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18 MeSH Terms
Interleukin-4 and interleukin-13 signaling connections maps.
Kelly-Welch AE, Hanson EM, Boothby MR, Keegan AD
(2003) Science 300: 1527-8
MeSH Terms: Amino Acid Motifs, Animals, Asthma, Humans, Hypersensitivity, Interleukin-13, Interleukin-13 Receptor alpha1 Subunit, Interleukin-4, Lymphocyte Activation, Phosphatidylinositol 3-Kinases, Phosphoproteins, Phosphorylation, Phosphotyrosine, Protein Structure, Tertiary, Protein-Tyrosine Kinases, Receptors, Antigen, T-Cell, Receptors, Interleukin, Receptors, Interleukin-13, Receptors, Interleukin-4, STAT6 Transcription Factor, Signal Transduction, T-Lymphocytes, Trans-Activators, src Homology Domains
Show Abstract · Added December 10, 2013
Cytokines are inflammatory mediators important in responding to pathogens and other foreign challenges. Interleukin-4 (IL-4) and IL-13 are two cytokines produced by T helper type 2 cells, mast cells, and basophils. In addition to their physiological roles, these cytokines are also implicated in pathological conditions such as asthma and allergy. IL-4 can stimulate two receptors, type I and type II, whereas IL-13 signaling is mediated only by the type II receptor (see the STKE Connections Maps). These cytokines activate the Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling cascades, which may contribute to allergic responses. In addition, stimulation of the phosphatidylinositol 3-kinase (PI3K) pathway through recruitment of members of the insulin receptor substrate family may contribute to survival and proliferation.
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24 MeSH Terms