The Gain-of-Function Integrin β3 Pro33 Variant Alters the Serotonin System in the Mouse Brain.
Dohn MR, Kooker CG, Bastarache L, Jessen T, Rinaldi C, Varney S, Mazalouskas MD, Pan H, Oliver KH, Velez Edwards DR, Sutcliffe JS, Denny JC, Carneiro AMD
(2017) J Neurosci 37
: 11271-11284MeSH Terms: Animals, Brain, Female, Gain of Function Mutation, Gene Knock-In Techniques, Genetic Variation, Humans, Integrin beta3, Male, Mice, Mice, Inbred C57BL, Mice, Transgenic, Proline, Protein Binding, Serotonin, Serotonin Plasma Membrane Transport ProteinsAdded November 2, 2017
16 MeSH Terms
Implications of the differing roles of the β1 and β3 transmembrane and cytoplasmic domains for integrin function.
Lu Z, Mathew S, Chen J, Hadziselimovic A, Palamuttam R, Hudson BG, Fässler R, Pozzi A, Sanders CR, Zent R
(2016) Elife 5
: MeSH Terms: Amino Acid Substitution, Cell Adhesion, Cells, Cultured, Epithelial Cells, Humans, Integrin alpha1, Integrin beta1, Integrin beta3, Mutagenesis, Site-Directed, Mutant Proteins, Platelet Membrane Glycoprotein IIb, Protein Binding, Protein MultimerizationAdded March 26, 2017
13 MeSH Terms
Contributions of Protease-Activated Receptors PAR1 and PAR4 to Thrombin-Induced GPIIbIIIa Activation in Human Platelets.
Duvernay MT, Temple KJ, Maeng JG, Blobaum AL, Stauffer SR, Lindsley CW, Hamm HE
(2017) Mol Pharmacol 91
: 39-47MeSH Terms: Blood Platelets, Humans, Integrin beta3, Ligands, Platelet Glycoprotein GPIb-IX Complex, Receptor, PAR-1, Receptors, Thrombin, Signal Transduction, ThrombinAdded March 24, 2020
Matrix rigidity regulates the transition of tumor cells to a bone-destructive phenotype through integrin β3 and TGF-β receptor type II.
Page JM, Merkel AR, Ruppender NS, Guo R, Dadwal UC, Cannonier S, Basu S, Guelcher SA, Sterling JA
(2015) Biomaterials 64
: 33-44MeSH Terms: Adenocarcinoma, Animals, Bone Neoplasms, Breast Neoplasms, Carcinoma, Squamous Cell, Cell Line, Tumor, Elastic Modulus, Extracellular Matrix, Female, Gene Expression Regulation, Neoplastic, Humans, Integrin beta3, Kruppel-Like Transcription Factors, Lung Neoplasms, Mice, Mice, Nude, Neoplasm Proteins, Nuclear Proteins, Osteolysis, Pliability, Protein Serine-Threonine Kinases, Receptor, Transforming Growth Factor-beta Type II, Receptors, Transforming Growth Factor beta, Transfection, Transforming Growth Factor beta, Tumor Microenvironment, Xenograft Model Antitumor Assays, Zinc Finger Protein Gli2Added February 23, 2016
28 MeSH Terms
Integrin β3 Haploinsufficiency Modulates Serotonin Transport and Antidepressant-Sensitive Behavior in Mice.
Mazalouskas M, Jessen T, Varney S, Sutcliffe JS, Veenstra-VanderWeele J, Cook EH, Carneiro AM
(2015) Neuropsychopharmacology 40
: 2015-24MeSH Terms: Analysis of Variance, Animals, Antidepressive Agents, Biological Transport, Gene Expression Regulation, Humans, Infant, Integrin beta3, Mice, Mice, Transgenic, Neurons, Phosphopyruvate Hydratase, Polymorphism, Genetic, Raphe Nuclei, Serotonin, Serotonin Plasma Membrane Transport Proteins, Serotonin Uptake Inhibitors, Synaptic MembranesAdded February 15, 2016
18 MeSH Terms
Pro32Pro33 mutations in the integrin β3 PSI domain result in αIIbβ3 priming and enhanced adhesion: reversal of the hypercoagulability phenotype by the Src inhibitor SKI-606.
Oliver KH, Jessen T, Crawford EL, Chung CY, Sutcliffe JS, Carneiro AM
(2014) Mol Pharmacol 85
: 921-31MeSH Terms: Amino Acid Sequence, Aniline Compounds, Animals, Base Sequence, Cell Adhesion, DNA Primers, Humans, Integrin beta3, Mice, Molecular Sequence Data, Mutation, Nitriles, Phenotype, Platelet Glycoprotein GPIIb-IIIa Complex, Polymerase Chain Reaction, Proline, Quinolines, Sequence Homology, Amino Acid, Thrombophilia, src-Family KinasesAdded February 12, 2015
20 MeSH Terms
Serotonin transporter and integrin beta 3 genes interact to modulate serotonin uptake in mouse brain.
Whyte A, Jessen T, Varney S, Carneiro AM
(2014) Neurochem Int 73
: 122-6MeSH Terms: Animals, Brain Chemistry, Citalopram, Integrin beta3, Mice, Mice, Knockout, Serotonin, Serotonin Plasma Membrane Transport Proteins, Serotonin Uptake Inhibitors, Synapses, SynaptosomesAdded February 12, 2015
11 MeSH Terms
β1 integrin NPXY motifs regulate kidney collecting-duct development and maintenance by induced-fit interactions with cytosolic proteins.
Mathew S, Lu Z, Palamuttam RJ, Mernaugh G, Hadziselimovic A, Chen J, Bulus N, Gewin LS, Voehler M, Meves A, Ballestrem C, Fässler R, Pozzi A, Sanders CR, Zent R
(2012) Mol Cell Biol 32
: 4080-91MeSH Terms: Amino Acid Motifs, Amino Acid Sequence, Animals, Cell Line, Cytosol, Humans, Integrin beta1, Integrin beta3, Kidney Tubules, Collecting, Membrane Proteins, Mice, Molecular Sequence Data, Mutation, Neoplasm Proteins, Protein Binding, Protein Conformation, Talin, TyrosineAdded February 24, 2014
18 MeSH Terms
Absence of preference for social novelty and increased grooming in integrin β3 knockout mice: initial studies and future directions.
Carter MD, Shah CR, Muller CL, Crawley JN, Carneiro AM, Veenstra-VanderWeele J
(2011) Autism Res 4
: 57-67MeSH Terms: Animals, Brain, Child, Child Development Disorders, Pervasive, Choice Behavior, Disease Models, Animal, Exploratory Behavior, Grooming, Humans, Integrin beta3, Male, Mice, Mice, Inbred C57BL, Mice, Knockout, Motor Activity, Phenotype, Quantitative Trait Loci, Serotonin, Social Behavior, Social Environment, Stereotyped BehaviorAdded February 12, 2015
21 MeSH Terms
Variation in ITGB3 is associated with whole-blood serotonin level and autism susceptibility.
Weiss LA, Kosova G, Delahanty RJ, Jiang L, Cook EH, Ober C, Sutcliffe JS
(2006) Eur J Hum Genet 14
: 923-31MeSH Terms: Alleles, Autistic Disorder, Case-Control Studies, Female, Founder Effect, Genetic Predisposition to Disease, Genetic Variation, Humans, Integrin beta3, Male, Pedigree, Polymorphism, Single Nucleotide, Quantitative Trait Loci, Serotonin, Sex FactorsAdded February 20, 2014
15 MeSH Terms