α2β1 integrin, GPVI receptor, and common FcRγ chain on mouse platelets mediate distinct responses to collagen in models of thrombosis.
Marjoram RJ, Li Z, He L, Tollefsen DM, Kunicki TJ, Dickeson SK, Santoro SA, Zutter MM
(2014) PLoS One 9
: e114035MeSH Terms: Animals, Blood Platelets, Collagen, Disease Models, Animal, Integrin alpha2beta1, Mice, Mice, Knockout, Platelet Activation, Platelet Membrane Glycoproteins, Rats, Receptors, IgG, ThrombosisAdded February 12, 2015
12 MeSH Terms
Madamanchi A, Santoro SA, Zutter MM
(2014) Adv Exp Med Biol 819
: 41-60MeSH Terms: Animals, Hemostasis, Humans, Immunity, Innate, Integrin alpha2beta1, Neovascularization, Physiologic, Protein Structure, Tertiary, Signal Transduction, Wound HealingAdded February 12, 2015
9 MeSH Terms
Mitigation of oxygen-induced retinopathy in α2β1 integrin-deficient mice.
Madamanchi A, Capozzi M, Geng L, Li Z, Friedman RD, Dickeson SK, Penn JS, Zutter MM
(2014) Invest Ophthalmol Vis Sci 55
: 4338-47MeSH Terms: Animals, Animals, Newborn, Cells, Cultured, Disease Models, Animal, Endothelium, Vascular, Ependymoglial Cells, Gene Expression Regulation, Integrin alpha2beta1, Mice, Mice, Inbred C57BL, Microscopy, Fluorescence, Oxygen, Polymerase Chain Reaction, RNA, Retinopathy of Prematurity, Vascular Endothelial Growth Factor AAdded February 19, 2015
16 MeSH Terms
Inhibition of integrin α2β1 ameliorates glomerular injury.
Borza CM, Su Y, Chen X, Yu L, Mont S, Chetyrkin S, Voziyan P, Hudson BG, Billings PC, Jo H, Bennett JS, Degrado WF, Eckes B, Zent R, Pozzi A
(2012) J Am Soc Nephrol 23
: 1027-38MeSH Terms: Acute Kidney Injury, Albuminuria, Analysis of Variance, Animals, Blotting, Western, Disease Models, Animal, Doxorubicin, Enzyme-Linked Immunosorbent Assay, Flow Cytometry, Immunohistochemistry, Integrin alpha2beta1, Kidney Function Tests, Kidney Glomerulus, Male, Mesangial Cells, Mice, Mice, Inbred BALB C, Mice, Knockout, Random Allocation, Receptors, CollagenAdded February 25, 2014
20 MeSH Terms
Loss of the α2β1 integrin alters human papilloma virus-induced squamous carcinoma progression in vivo and in vitro.
Tran T, Barlow B, O'Rear L, Jarvis B, Li Z, Dickeson K, Dupont W, Zutter M
(2011) PLoS One 6
: e26858MeSH Terms: Animals, Carcinoma, Squamous Cell, Cell Line, Tumor, Cell Movement, Cell Proliferation, Disease Progression, Human papillomavirus 16, Humans, Integrin alpha2beta1, Mice, Mice, Transgenic, Neoplasm Invasiveness, Neoplasm Metastasis, Neoplasm Transplantation, Papillomavirus InfectionsAdded February 16, 2014
15 MeSH Terms
Selective, α2β1 integrin-dependent secretion of il-6 by connective tissue mast cells.
McCall-Culbreath KD, Li Z, Zhang Z, Lu LX, Orear L, Zutter MM
(2011) J Innate Immun 3
: 459-70MeSH Terms: Animals, Antigens, Bacterial, Calcium Signaling, Cell Degranulation, Cells, Cultured, Connective Tissue, Humans, Immunity, Innate, Immunoglobulin E, Integrin alpha2beta1, Interleukin-6, Listeria monocytogenes, Mast Cells, Mice, Mice, Inbred C57BL, Mice, Knockout, Receptor AggregationAdded February 16, 2014
17 MeSH Terms
Diet-induced muscle insulin resistance is associated with extracellular matrix remodeling and interaction with integrin alpha2beta1 in mice.
Kang L, Ayala JE, Lee-Young RS, Zhang Z, James FD, Neufer PD, Pozzi A, Zutter MM, Wasserman DH
(2011) Diabetes 60
: 416-26MeSH Terms: Analysis of Variance, Animals, Blotting, Western, Collagen Type III, Collagen Type V, Diet, Extracellular Matrix, Glucose Clamp Technique, Immunohistochemistry, Insulin, Insulin Resistance, Integrin alpha2beta1, Matrix Metalloproteinase 9, Mice, Mice, Knockout, Muscle, Skeletal, Phosphodiesterase 5 Inhibitors, Piperazines, Purines, Reverse Transcriptase Polymerase Chain Reaction, Sildenafil Citrate, SulfonesAdded February 24, 2014
22 MeSH Terms
The α₂β₁ integrin is a metastasis suppressor in mouse models and human cancer.
Ramirez NE, Zhang Z, Madamanchi A, Boyd KL, O'Rear LD, Nashabi A, Li Z, Dupont WD, Zijlstra A, Zutter MM
(2011) J Clin Invest 121
: 226-37MeSH Terms: Animals, Base Sequence, Biomarkers, Tumor, Breast Neoplasms, DNA Primers, Female, Genes, erbB-2, Humans, In Vitro Techniques, Integrin alpha2beta1, Kaplan-Meier Estimate, Male, Mammary Neoplasms, Experimental, Mice, Mice, Knockout, Mice, Transgenic, Neoplasm Invasiveness, Neoplasm Metastasis, Prognosis, Prostatic Neoplasms, Tumor Stem Cell Assay, Tumor Suppressor ProteinsAdded February 16, 2014
22 MeSH Terms
Entry of Bacillus anthracis spores into epithelial cells is mediated by the spore surface protein BclA, integrin α2β1 and complement component C1q.
Xue Q, Gu C, Rivera J, Höök M, Chen X, Pozzi A, Xu Y
(2011) Cell Microbiol 13
: 620-34MeSH Terms: Animals, Anthrax, Bacillus anthracis, Bacterial Adhesion, CHO Cells, Cell Line, Complement C1q, Cricetinae, Cricetulus, Endocytosis, Epithelial Cells, Humans, Integrin alpha2beta1, Membrane Glycoproteins, Mice, Skin Diseases, Bacterial, Spores, BacterialAdded February 24, 2014
17 MeSH Terms
Suboptimal activation of protease-activated receptors enhances alpha2beta1 integrin-mediated platelet adhesion to collagen.
Marjoram RJ, Voss B, Pan Y, Dickeson SK, Zutter MM, Hamm HE, Santoro SA
(2009) J Biol Chem 284
: 34640-7MeSH Terms: Amino Acid Motifs, Animals, Blood Platelets, Carrier Proteins, Collagen, GTP-Binding Protein alpha Subunits, Gi-Go, Humans, Integrin alpha2beta1, Mice, Mice, Inbred C57BL, Peptides, Platelet Adhesiveness, Platelet Aggregation, Platelet Membrane Glycoproteins, Rats, Receptor, PAR-1, Receptors, Collagen, Receptors, G-Protein-Coupled, Receptors, IgG, Receptors, Thrombin, Signal Transduction, Thrombin, Type C PhospholipasesAdded December 10, 2013
23 MeSH Terms