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Salt-bridge modulates differential calcium-mediated ligand binding to integrin α1- and α2-I domains.
Brown KL, Banerjee S, Feigley A, Abe H, Blackwell TS, Pozzi A, Hudson BG, Zent R
(2018) Sci Rep 8: 2916
MeSH Terms: Amino Acid Sequence, Calcium, Hydrogen Bonding, Integrin alpha1, Integrin alpha2, Ligands, Models, Molecular, Protein Binding, Protein Domains, Thermodynamics
Added March 21, 2018
0 Communities
1 Members
0 Resources
10 MeSH Terms
α2β1 integrin, GPVI receptor, and common FcRγ chain on mouse platelets mediate distinct responses to collagen in models of thrombosis.
Marjoram RJ, Li Z, He L, Tollefsen DM, Kunicki TJ, Dickeson SK, Santoro SA, Zutter MM
(2014) PLoS One 9: e114035
MeSH Terms: Animals, Blood Platelets, Collagen, Disease Models, Animal, Integrin alpha2beta1, Mice, Mice, Knockout, Platelet Activation, Platelet Membrane Glycoproteins, Rats, Receptors, IgG, Thrombosis
Added February 12, 2015
1 Communities
1 Members
0 Resources
12 MeSH Terms
α2β1 Integrin.
Madamanchi A, Santoro SA, Zutter MM
(2014) Adv Exp Med Biol 819: 41-60
MeSH Terms: Animals, Hemostasis, Humans, Immunity, Innate, Integrin alpha2beta1, Neovascularization, Physiologic, Protein Structure, Tertiary, Signal Transduction, Wound Healing
Added February 12, 2015
1 Communities
1 Members
0 Resources
9 MeSH Terms
Transforming growth factor beta receptor type III is a tumor promoter in mesenchymal-stem like triple negative breast cancer.
Jovanović B, Beeler JS, Pickup MW, Chytil A, Gorska AE, Ashby WJ, Lehmann BD, Zijlstra A, Pietenpol JA, Moses HL
(2014) Breast Cancer Res 16: R69
MeSH Terms: Animals, Cell Line, Tumor, Cell Movement, Cell Proliferation, Cell Survival, Cell Transformation, Neoplastic, Cluster Analysis, Disease Models, Animal, Female, Gene Expression, Gene Expression Profiling, Gene Expression Regulation, Neoplastic, Gene Knockdown Techniques, Heterografts, Humans, Integrin alpha2, Mesenchymal Stem Cells, Mice, Proteoglycans, RNA, Messenger, RNA, Small Interfering, Receptors, Transforming Growth Factor beta, Spheroids, Cellular, Triple Negative Breast Neoplasms, Tumor Burden, Tumor Cells, Cultured
Added July 10, 2014
1 Communities
4 Members
0 Resources
26 MeSH Terms
Mitigation of oxygen-induced retinopathy in α2β1 integrin-deficient mice.
Madamanchi A, Capozzi M, Geng L, Li Z, Friedman RD, Dickeson SK, Penn JS, Zutter MM
(2014) Invest Ophthalmol Vis Sci 55: 4338-47
MeSH Terms: Animals, Animals, Newborn, Cells, Cultured, Disease Models, Animal, Endothelium, Vascular, Ependymoglial Cells, Gene Expression Regulation, Integrin alpha2beta1, Mice, Mice, Inbred C57BL, Microscopy, Fluorescence, Oxygen, Polymerase Chain Reaction, RNA, Retinopathy of Prematurity, Vascular Endothelial Growth Factor A
Added February 19, 2015
1 Communities
1 Members
0 Resources
16 MeSH Terms
Integrin β1 is critical for gastrin-releasing peptide receptor-mediated neuroblastoma cell migration and invasion.
Lee S, Qiao J, Paul P, Chung DH
(2013) Surgery 154: 369-75
MeSH Terms: Cell Line, Tumor, Cell Movement, Gastrin-Releasing Peptide, Humans, Integrin alpha2, Integrin alpha3, Integrin beta1, Neoplasm Invasiveness, Neuroblastoma, Receptors, Bombesin
Added March 7, 2014
0 Communities
1 Members
0 Resources
10 MeSH Terms
Rab25 regulates integrin expression in polarized colonic epithelial cells.
Krishnan M, Lapierre LA, Knowles BC, Goldenring JR
(2013) Mol Biol Cell 24: 818-31
MeSH Terms: Adenovirus E1A Proteins, Caco-2 Cells, Cell Line, Tumor, Cell Movement, Cell Polarity, Claudin-1, Epithelial Cells, Gene Expression Regulation, Gene Expression Regulation, Neoplastic, HEK293 Cells, Humans, Integrin alpha2, Integrin alpha5, Integrin alpha5beta1, Integrin beta1, Integrins, Intestinal Mucosa, Microvilli, Neoplasm Invasiveness, Proto-Oncogene Proteins, Proto-Oncogene Proteins c-ets, RNA Interference, rab GTP-Binding Proteins
Added October 7, 2013
1 Communities
2 Members
0 Resources
23 MeSH Terms
Inhibition of integrin α2β1 ameliorates glomerular injury.
Borza CM, Su Y, Chen X, Yu L, Mont S, Chetyrkin S, Voziyan P, Hudson BG, Billings PC, Jo H, Bennett JS, Degrado WF, Eckes B, Zent R, Pozzi A
(2012) J Am Soc Nephrol 23: 1027-38
MeSH Terms: Acute Kidney Injury, Albuminuria, Analysis of Variance, Animals, Blotting, Western, Disease Models, Animal, Doxorubicin, Enzyme-Linked Immunosorbent Assay, Flow Cytometry, Immunohistochemistry, Integrin alpha2beta1, Kidney Function Tests, Kidney Glomerulus, Male, Mesangial Cells, Mice, Mice, Inbred BALB C, Mice, Knockout, Random Allocation, Receptors, Collagen
Added February 25, 2014
1 Communities
7 Members
1 Resources
20 MeSH Terms
Loss of the α2β1 integrin alters human papilloma virus-induced squamous carcinoma progression in vivo and in vitro.
Tran T, Barlow B, O'Rear L, Jarvis B, Li Z, Dickeson K, Dupont W, Zutter M
(2011) PLoS One 6: e26858
MeSH Terms: Animals, Carcinoma, Squamous Cell, Cell Line, Tumor, Cell Movement, Cell Proliferation, Disease Progression, Human papillomavirus 16, Humans, Integrin alpha2beta1, Mice, Mice, Transgenic, Neoplasm Invasiveness, Neoplasm Metastasis, Neoplasm Transplantation, Papillomavirus Infections
Added February 16, 2014
2 Communities
3 Members
0 Resources
15 MeSH Terms
Selective, α2β1 integrin-dependent secretion of il-6 by connective tissue mast cells.
McCall-Culbreath KD, Li Z, Zhang Z, Lu LX, Orear L, Zutter MM
(2011) J Innate Immun 3: 459-70
MeSH Terms: Animals, Antigens, Bacterial, Calcium Signaling, Cell Degranulation, Cells, Cultured, Connective Tissue, Humans, Immunity, Innate, Immunoglobulin E, Integrin alpha2beta1, Interleukin-6, Listeria monocytogenes, Mast Cells, Mice, Mice, Inbred C57BL, Mice, Knockout, Receptor Aggregation
Added February 16, 2014
1 Communities
1 Members
0 Resources
17 MeSH Terms