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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 18

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Integrin α1β1 protects against signs of post-traumatic osteoarthritis in the female murine knee partially via regulation of epidermal growth factor receptor signalling.
Shin SY, Pozzi A, Boyd SK, Clark AL
(2016) Osteoarthritis Cartilage 24: 1795-1806
MeSH Terms: Animals, Cartilage, Articular, Disease Models, Animal, ErbB Receptors, Female, Integrin alpha1beta1, Knee Joint, Male, Mice, Osteoarthritis, Signal Transduction, X-Ray Microtomography
Added October 30, 2016
1 Communities
0 Members
0 Resources
12 MeSH Terms
Integrin-mediated type II TGF-β receptor tyrosine dephosphorylation controls SMAD-dependent profibrotic signaling.
Chen X, Wang H, Liao HJ, Hu W, Gewin L, Mernaugh G, Zhang S, Zhang ZY, Vega-Montoto L, Vanacore RM, Fässler R, Zent R, Pozzi A
(2014) J Clin Invest 124: 3295-310
MeSH Terms: Animals, Collagen, Epithelial-Mesenchymal Transition, Fibrosis, Integrin alpha1, Integrin alpha1beta1, Kidney, Male, Mice, Mice, Inbred BALB C, Mice, Inbred C57BL, Mice, Knockout, Phosphorylation, Protein Serine-Threonine Kinases, Protein Tyrosine Phosphatase, Non-Receptor Type 2, Receptor, Transforming Growth Factor-beta Type II, Receptors, Transforming Growth Factor beta, Signal Transduction, Smad Proteins, Smad2 Protein, Smad3 Protein, Tyrosine, Ureteral Obstruction
Added October 27, 2014
2 Communities
4 Members
1 Resources
23 MeSH Terms
Integrin α1β1 participates in chondrocyte transduction of osmotic stress.
Jablonski CL, Ferguson S, Pozzi A, Clark AL
(2014) Biochem Biophys Res Commun 445: 184-90
MeSH Terms: Animals, Calcium, Cells, Cultured, Chondrocytes, Female, Immunohistochemistry, Integrin alpha1beta1, Leucine, Male, Mice, Mice, Inbred BALB C, Mice, Knockout, Microscopy, Confocal, Osmotic Pressure, Signal Transduction, Sulfonamides, TRPV Cation Channels
Added February 24, 2014
0 Communities
1 Members
0 Resources
17 MeSH Terms
Enhancing integrin α1 inserted (I) domain affinity to ligand potentiates integrin α1β1-mediated down-regulation of collagen synthesis.
Shi M, Pedchenko V, Greer BH, Van Horn WD, Santoro SA, Sanders CR, Hudson BG, Eichman BF, Zent R, Pozzi A
(2012) J Biol Chem 287: 35139-35152
MeSH Terms: Amino Acid Substitution, Animals, Cell Line, Transformed, Collagen Type IV, Down-Regulation, Enzyme Activation, Extracellular Signal-Regulated MAP Kinases, Humans, Integrin alpha1beta1, Laminin, Ligands, MAP Kinase Signaling System, Mice, Mice, Mutant Strains, Models, Molecular, Mutation, Missense, Nuclear Magnetic Resonance, Biomolecular, Protein Binding, Protein Biosynthesis, Protein Structure, Tertiary
Added February 24, 2014
1 Communities
6 Members
1 Resources
20 MeSH Terms
Integrin {alpha}1{beta}1 promotes caveolin-1 dephosphorylation by activating T cell protein-tyrosine phosphatase.
Borza CM, Chen X, Mathew S, Mont S, Sanders CR, Zent R, Pozzi A
(2010) J Biol Chem 285: 40114-24
MeSH Terms: Animals, CHO Cells, Caveolin 1, Collagen, Cricetinae, Cricetulus, Enzyme Activation, Fibrosis, HEK293 Cells, Humans, Integrin alpha1beta1, Mice, Mice, Mutant Strains, Oxidative Stress, Phosphorylation, Protein Tyrosine Phosphatase, Non-Receptor Type 2, Reactive Oxygen Species, Recombinant Proteins
Added February 24, 2014
1 Communities
5 Members
1 Resources
18 MeSH Terms
Integrin alpha1beta1 regulates epidermal growth factor receptor activation by controlling peroxisome proliferator-activated receptor gamma-dependent caveolin-1 expression.
Chen X, Whiting C, Borza C, Hu W, Mont S, Bulus N, Zhang MZ, Harris RC, Zent R, Pozzi A
(2010) Mol Cell Biol 30: 3048-58
MeSH Terms: Animals, Caveolae, Caveolin 1, Cell Nucleus, Down-Regulation, Enzyme Activation, ErbB Receptors, Extracellular Signal-Regulated MAP Kinases, Humans, Integrin alpha1beta1, Mesangial Cells, Mice, Mice, Inbred C57BL, Models, Biological, PPAR gamma, Phosphorylation, Protein Transport, Reactive Oxygen Species
Added February 24, 2014
1 Communities
6 Members
0 Resources
18 MeSH Terms
Selective binding of integrins from different renal cell types to the NC1 domain of alpha3 and alpha1 chains of type IV collagen.
Aggeli AS, Kitsiou PV, Tzinia AK, Boutaud A, Hudson BG, Tsilibary EC
(2009) J Nephrol 22: 130-6
MeSH Terms: Autoantigens, Cell Line, Collagen Type IV, Down-Regulation, Epithelial Cells, Humans, Integrin alpha1beta1, Integrin alpha2beta1, Integrins, Kidney Glomerulus, Kidney Tubules, Proximal, Matrix Metalloproteinase 2, Matrix Metalloproteinase 9, Mesangial Cells, Protein Binding, Protein Isoforms, Signal Transduction
Added December 10, 2013
1 Communities
1 Members
0 Resources
17 MeSH Terms
Regulation of the atheroma-enriched protein, SPRR3, in vascular smooth muscle cells through cyclic strain is dependent on integrin alpha1beta1/collagen interaction.
Pyle AL, Atkinson JB, Pozzi A, Reese J, Eckes B, Davidson JM, Crimmins DL, Young PP
(2008) Am J Pathol 173: 1577-88
MeSH Terms: Animals, Atherosclerosis, Collagen, Humans, Integrin alpha1beta1, Lipids, Mice, Mice, Inbred C57BL, Models, Biological, Muscle, Smooth, Vascular, Myocytes, Smooth Muscle, Peptides, Proline-Rich Protein Domains, Protein Binding, Protein Transport, Stress, Mechanical, Transcription, Genetic, Up-Regulation
Added February 24, 2014
0 Communities
2 Members
0 Resources
18 MeSH Terms
Cross-talk between integrins alpha1beta1 and alpha2beta1 in renal epithelial cells.
Abair TD, Sundaramoorthy M, Chen D, Heino J, Ivaska J, Hudson BG, Sanders CR, Pozzi A, Zent R
(2008) Exp Cell Res 314: 3593-604
MeSH Terms: Animals, Epithelial Cells, Fluorescent Antibody Technique, Humans, Integrin alpha1beta1, Integrin alpha2beta1, Kidney, Mice, Signal Transduction
Added February 24, 2014
1 Communities
4 Members
1 Resources
9 MeSH Terms
Loss of integrin alpha1beta1 ameliorates Kras-induced lung cancer.
Macias-Perez I, Borza C, Chen X, Yan X, Ibanez R, Mernaugh G, Matrisian LM, Zent R, Pozzi A
(2008) Cancer Res 68: 6127-35
MeSH Terms: Animals, Cell Adhesion, Cell Proliferation, Collagen Type IV, Extracellular Signal-Regulated MAP Kinases, Genes, ras, Immunohistochemistry, Integrin alpha1beta1, Lung Neoplasms, Mice, Mice, Knockout, Survival Analysis
Added February 24, 2014
1 Communities
3 Members
0 Resources
12 MeSH Terms