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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 34

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An interspecies translation model implicates integrin signaling in infliximab-resistant inflammatory bowel disease.
Brubaker DK, Kumar MP, Chiswick EL, Gregg C, Starchenko A, Vega PN, Southard-Smith AN, Simmons AJ, Scoville EA, Coburn LA, Wilson KT, Lau KS, Lauffenburger DA
(2020) Sci Signal 13:
MeSH Terms: Animals, Cells, Cultured, Disease Models, Animal, Drug Resistance, Gastrointestinal Agents, Gene Expression Profiling, Humans, Inflammatory Bowel Diseases, Infliximab, Integrin alpha1, Integrins, Male, Mice, Proteomics, RNA-Seq, Signal Transduction, Single-Cell Analysis, Species Specificity, Translational Medical Research
Added August 6, 2020
0 Communities
1 Members
0 Resources
19 MeSH Terms
Salt-bridge modulates differential calcium-mediated ligand binding to integrin α1- and α2-I domains.
Brown KL, Banerjee S, Feigley A, Abe H, Blackwell TS, Pozzi A, Hudson BG, Zent R
(2018) Sci Rep 8: 2916
MeSH Terms: Amino Acid Sequence, Calcium, Hydrogen Bonding, Integrin alpha1, Integrin alpha2, Ligands, Models, Molecular, Protein Binding, Protein Domains, Thermodynamics
Added March 21, 2018
0 Communities
1 Members
0 Resources
10 MeSH Terms
Implications of the differing roles of the β1 and β3 transmembrane and cytoplasmic domains for integrin function.
Lu Z, Mathew S, Chen J, Hadziselimovic A, Palamuttam R, Hudson BG, Fässler R, Pozzi A, Sanders CR, Zent R
(2016) Elife 5:
MeSH Terms: Amino Acid Substitution, Cell Adhesion, Cells, Cultured, Epithelial Cells, Humans, Integrin alpha1, Integrin beta1, Integrin beta3, Mutagenesis, Site-Directed, Mutant Proteins, Platelet Membrane Glycoprotein IIb, Protein Binding, Protein Multimerization
Added March 26, 2017
1 Communities
3 Members
1 Resources
13 MeSH Terms
Integrin α1β1 protects against signs of post-traumatic osteoarthritis in the female murine knee partially via regulation of epidermal growth factor receptor signalling.
Shin SY, Pozzi A, Boyd SK, Clark AL
(2016) Osteoarthritis Cartilage 24: 1795-1806
MeSH Terms: Animals, Cartilage, Articular, Disease Models, Animal, ErbB Receptors, Female, Integrin alpha1beta1, Knee Joint, Male, Mice, Osteoarthritis, Signal Transduction, X-Ray Microtomography
Added October 30, 2016
1 Communities
0 Members
0 Resources
12 MeSH Terms
Serum Metabolite Profiles Are Altered by Erlotinib Treatment and the Integrin α1-Null Genotype but Not by Post-Traumatic Osteoarthritis.
Mickiewicz B, Shin SY, Pozzi A, Vogel HJ, Clark AL
(2016) J Proteome Res 15: 815-25
MeSH Terms: Animals, ErbB Receptors, Erlotinib Hydrochloride, Female, Integrin alpha1, Male, Menisci, Tibial, Metabolome, Mice, Mice, Knockout, Osteoarthritis, Knee, Reactive Oxygen Species, Transient Receptor Potential Channels
Added October 30, 2016
1 Communities
0 Members
0 Resources
13 MeSH Terms
Integrin α1-null mice exhibit improved fatty liver when fed a high fat diet despite severe hepatic insulin resistance.
Williams AS, Kang L, Zheng J, Grueter C, Bracy DP, James FD, Pozzi A, Wasserman DH
(2015) J Biol Chem 290: 6546-57
MeSH Terms: Animals, Diet, High-Fat, Fatty Liver, Glucose, Hepatocytes, Humans, Insulin, Insulin Resistance, Integrin alpha1, Liver, Mice, Mice, Knockout, Triglycerides
Added February 15, 2015
1 Communities
3 Members
0 Resources
13 MeSH Terms
p47(phox) contributes to albuminuria and kidney fibrosis in mice.
Wang H, Chen X, Su Y, Paueksakon P, Hu W, Zhang MZ, Harris RC, Blackwell TS, Zent R, Pozzi A
(2015) Kidney Int 87: 948-62
MeSH Terms: Albuminuria, Animals, Collagen Type IV, Doxorubicin, ErbB Receptors, Integrin alpha1, Kidney, Male, Mice, Inbred BALB C, Mice, Inbred C57BL, NADPH Oxidases, Nephrosclerosis, Oxidative Stress, Reactive Oxygen Species, rac GTP-Binding Proteins
Added January 20, 2015
1 Communities
4 Members
1 Resources
15 MeSH Terms
Integrin-mediated type II TGF-β receptor tyrosine dephosphorylation controls SMAD-dependent profibrotic signaling.
Chen X, Wang H, Liao HJ, Hu W, Gewin L, Mernaugh G, Zhang S, Zhang ZY, Vega-Montoto L, Vanacore RM, Fässler R, Zent R, Pozzi A
(2014) J Clin Invest 124: 3295-310
MeSH Terms: Animals, Collagen, Epithelial-Mesenchymal Transition, Fibrosis, Integrin alpha1, Integrin alpha1beta1, Kidney, Male, Mice, Mice, Inbred BALB C, Mice, Inbred C57BL, Mice, Knockout, Phosphorylation, Protein Tyrosine Phosphatase, Non-Receptor Type 2, Protein-Serine-Threonine Kinases, Receptor, Transforming Growth Factor-beta Type II, Receptors, Transforming Growth Factor beta, Signal Transduction, Smad Proteins, Smad2 Protein, Smad3 Protein, Tyrosine, Ureteral Obstruction
Added October 27, 2014
2 Communities
4 Members
1 Resources
23 MeSH Terms
Integrin α1β1 participates in chondrocyte transduction of osmotic stress.
Jablonski CL, Ferguson S, Pozzi A, Clark AL
(2014) Biochem Biophys Res Commun 445: 184-90
MeSH Terms: Animals, Calcium, Cells, Cultured, Chondrocytes, Female, Immunohistochemistry, Integrin alpha1beta1, Leucine, Male, Mice, Mice, Inbred BALB C, Mice, Knockout, Microscopy, Confocal, Osmotic Pressure, Signal Transduction, Sulfonamides, TRPV Cation Channels
Added February 24, 2014
0 Communities
1 Members
0 Resources
17 MeSH Terms
Upregulated expression of integrin α1 in mesangial cells and integrin α3 and vimentin in podocytes of Col4a3-null (Alport) mice.
Steenhard BM, Vanacore R, Friedman D, Zelenchuk A, Stroganova L, Isom K, St John PL, Hudson BG, Abrahamson DR
(2012) PLoS One 7: e50745
MeSH Terms: Animals, Autoantigens, Collagen Type IV, Disease Models, Animal, Glomerular Basement Membrane, Integrin alpha1, Integrin alpha3, Mesangial Cells, Mice, Mice, Knockout, Nephritis, Hereditary, Podocytes, Up-Regulation, Vimentin
Added August 21, 2013
1 Communities
2 Members
0 Resources
14 MeSH Terms