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Results: 1 to 10 of 225

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Tetraspanin-7 regulation of L-type voltage-dependent calcium channels controls pancreatic β-cell insulin secretion.
Dickerson MT, Dadi PK, Butterworth RB, Nakhe AY, Graff SM, Zaborska KE, Schaub CM, Jacobson DA
(2020) J Physiol 598: 4887-4905
MeSH Terms: Animals, Calcium, Calcium Channels, L-Type, Glucagon-Secreting Cells, Glucose, Insulin, Insulin Secretion, Insulin-Secreting Cells, Mice
Added June 14, 2021
0 Communities
1 Members
0 Resources
MeSH Terms
Glucose Regulates Microtubule Disassembly and the Dose of Insulin Secretion via Tau Phosphorylation.
Ho KH, Yang X, Osipovich AB, Cabrera O, Hayashi ML, Magnuson MA, Gu G, Kaverina I
(2020) Diabetes 69: 1936-1947
MeSH Terms: Animals, Cyclic AMP-Dependent Protein Kinases, Cyclin-Dependent Kinase 5, Glucose, Glycogen Synthase Kinase 3, Insulin Secretion, Insulin-Secreting Cells, Mice, Microtubules, Phosphorylation, Protein Kinase C, tau Proteins
Added July 2, 2020
2 Communities
4 Members
0 Resources
12 MeSH Terms
Dapagliflozin Does Not Directly Affect Human α or β Cells.
Dai C, Walker JT, Shostak A, Bouchi Y, Poffenberger G, Hart NJ, Jacobson DA, Calcutt MW, Bottino R, Greiner DL, Shultz LD, McGuinness OP, Dean ED, Powers AC
(2020) Endocrinology 161:
MeSH Terms: Adolescent, Adult, Animals, Benzhydryl Compounds, Cells, Cultured, Female, Glucagon, Glucagon-Secreting Cells, Glucosides, Heterografts, Humans, Insulin, Insulin Secretion, Insulin-Secreting Cells, Islets of Langerhans, Male, Mice, Mice, Inbred NOD, Mice, Transgenic, Middle Aged, Signal Transduction, Species Specificity, Young Adult
Added June 14, 2021
0 Communities
1 Members
0 Resources
MeSH Terms
Myt Transcription Factors Prevent Stress-Response Gene Overactivation to Enable Postnatal Pancreatic β Cell Proliferation, Function, and Survival.
Hu R, Walker E, Huang C, Xu Y, Weng C, Erickson GE, Coldren A, Yang X, Brissova M, Kaverina I, Balamurugan AN, Wright CVE, Li Y, Stein R, Gu G
(2020) Dev Cell 53: 390-405.e10
MeSH Terms: Activating Transcription Factor 4, Animals, Cell Proliferation, DNA-Binding Proteins, Diabetes Mellitus, Female, Heat-Shock Proteins, Humans, Insulin Secretion, Insulin-Secreting Cells, Male, Mice, Mice, Knockout, Stress, Physiological, Transcription Factors
Added May 6, 2020
3 Communities
2 Members
0 Resources
15 MeSH Terms
Excitotoxicity and Overnutrition Additively Impair Metabolic Function and Identity of Pancreatic β-Cells.
Osipovich AB, Stancill JS, Cartailler JP, Dudek KD, Magnuson MA
(2020) Diabetes 69: 1476-1491
MeSH Terms: Animals, Calcium, Cells, Cultured, Diet, High-Fat, Female, Gene Expression Regulation, Glucose, Insulin-Secreting Cells, Male, Mice, Mice, Inbred C57BL, Mitochondria, Overnutrition, Sex Characteristics, Transcriptome
Added April 28, 2020
2 Communities
3 Members
0 Resources
15 MeSH Terms
Ins1-Cre and Ins1-CreER Gene Replacement Alleles Are Susceptible To Silencing By DNA Hypermethylation.
Mosleh E, Ou K, Haemmerle MW, Tembo T, Yuhas A, Carboneau BA, Townsend SE, Bosma KJ, Gannon M, O'Brien RM, Stoffers DA, Golson ML
(2020) Endocrinology 161:
MeSH Terms: Alleles, Animals, Cells, Cultured, DNA Methylation, Female, Gene Silencing, HEK293 Cells, Humans, Insulin, Insulin-Secreting Cells, Integrases, Islets of Langerhans, Male, Mice, Mice, Inbred C57BL, Mice, Transgenic, Organ Specificity, Recombination, Genetic
Added May 12, 2020
1 Communities
0 Members
0 Resources
18 MeSH Terms
Coregulator Sin3a Promotes Postnatal Murine β-Cell Fitness by Regulating Genes in Ca Homeostasis, Cell Survival, Vesicle Biosynthesis, Glucose Metabolism, and Stress Response.
Yang X, Graff SM, Heiser CN, Ho KH, Chen B, Simmons AJ, Southard-Smith AN, David G, Jacobson DA, Kaverina I, Wright CVE, Lau KS, Gu G
(2020) Diabetes 69: 1219-1231
MeSH Terms: Aging, Animals, Basic Helix-Loop-Helix Transcription Factors, Calcium, Cell Survival, Diabetes Mellitus, Female, Gene Expression Regulation, Developmental, Homeostasis, Insulin-Secreting Cells, Male, Mice, Mice, Knockout, Nerve Tissue Proteins, Repressor Proteins, Sin3 Histone Deacetylase and Corepressor Complex
Added April 7, 2020
2 Communities
3 Members
0 Resources
16 MeSH Terms
Tacrolimus- and sirolimus-induced human β cell dysfunction is reversible and preventable.
Dai C, Walker JT, Shostak A, Padgett A, Spears E, Wisniewski S, Poffenberger G, Aramandla R, Dean ED, Prasad N, Levy SE, Greiner DL, Shultz LD, Bottino R, Powers AC
(2020) JCI Insight 5:
MeSH Terms: Animals, Calcineurin, Diabetes Mellitus, Graft Rejection, Humans, Immunosuppressive Agents, Insulin, Insulin-Secreting Cells, Islets of Langerhans, Islets of Langerhans Transplantation, Male, Mice, Signal Transduction, Sirolimus, TOR Serine-Threonine Kinases, Tacrolimus
Added March 29, 2020
0 Communities
1 Members
0 Resources
16 MeSH Terms
Microtubules Regulate Localization and Availability of Insulin Granules in Pancreatic Beta Cells.
Bracey KM, Ho KH, Yampolsky D, Gu G, Kaverina I, Holmes WR
(2020) Biophys J 118: 193-206
MeSH Terms: Animals, Insulin, Insulin-Secreting Cells, Mice, Microtubules, Models, Molecular
Added December 4, 2020
1 Communities
1 Members
0 Resources
6 MeSH Terms
Lipid Droplet Accumulation in Human Pancreatic Islets Is Dependent On Both Donor Age and Health.
Tong X, Dai C, Walker JT, Nair GG, Kennedy A, Carr RM, Hebrok M, Powers AC, Stein R
(2020) Diabetes 69: 342-354
MeSH Terms: Acinar Cells, Adolescent, Adult, Age Factors, Aged, Animals, Child, Child, Preschool, Diabetes Mellitus, Experimental, Diabetes Mellitus, Type 2, Embryonic Stem Cells, Female, Glucagon-Secreting Cells, Humans, Infant, Insulin-Secreting Cells, Islets of Langerhans, Islets of Langerhans Transplantation, Lipid Droplets, Male, Mice, Microscopy, Electron, Microscopy, Fluorescence, Middle Aged, Rats, Tissue Donors, Young Adult
Added March 29, 2020
0 Communities
1 Members
0 Resources
27 MeSH Terms