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Publication Record


Acute kidney injury risk-based screening in pediatric inpatients: a pragmatic randomized trial.
Van Driest SL, Wang L, McLemore MF, Bridges BC, Fleming GM, McGregor TL, Jones DP, Shirey-Rice J, Gatto CL, Gay JC, Byrne DW, Weitkamp A, Roden DM, Bernard G
(2020) Pediatr Res 87: 118-124
MeSH Terms: Acute Kidney Injury, Adolescent, Age Factors, Biomarkers, Child, Creatinine, Decision Support Systems, Clinical, Female, Hospital Information Systems, Humans, Infant, Inpatients, Intensive Care Units, Pediatric, Length of Stay, Male, Predictive Value of Tests, Reminder Systems, Risk Assessment, Risk Factors, Severity of Illness Index, Tennessee, Time Factors
Show Abstract · Added March 24, 2020
BACKGROUND - Pediatric acute kidney injury (AKI) is common and associated with increased morbidity, mortality, and length of stay. We performed a pragmatic randomized trial testing the hypothesis that AKI risk alerts increase AKI screening.
METHODS - All intensive care and ward admissions of children aged 28 days through 21 years without chronic kidney disease from 12/6/2016 to 11/1/2017 were included. The intervention alert displayed if calculated AKI risk was > 50% and no serum creatinine (SCr) was ordered within 24 h. The primary outcome was SCr testing within 48 h of AKI risk > 50%.
RESULTS - Among intensive care admissions, 973/1909 (51%) were randomized to the intervention. Among those at risk, more SCr tests were ordered for the intervention group than for controls (418/606, 69% vs. 361/597, 60%, p = 0.002). AKI incidence and severity were the same in intervention and control groups. Among ward admissions, 5492/10997 (50%) were randomized to the intervention, and there were no differences between groups in SCr testing, AKI incidence, or severity of AKI.
CONCLUSIONS - Alerts based on real-time prediction of AKI risk increased screening rates in intensive care but not pediatric ward settings. Pragmatic clinical trials provide the opportunity to assess clinical decision support and potentially eliminate ineffective alerts.
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22 MeSH Terms
Health literacy, cognition, and urinary incontinence among geriatric inpatients discharged to skilled nursing facilities.
Cohn JA, Shah AS, Goggins KM, Simmons SF, Kripalani S, Dmochowski RR, Schnelle JF, Reynolds WS
(2018) Neurourol Urodyn 37: 854-860
MeSH Terms: Aged, Aged, 80 and over, Cognition, Depression, Female, Frail Elderly, Geriatric Assessment, Health Literacy, Humans, Inpatients, Male, Patient Discharge, Sex Factors, Skilled Nursing Facilities, Urinary Incontinence
Show Abstract · Added September 16, 2019
AIMS - To investigate the association between health literacy and cognition and nursing and patient-reported incontinence in a geriatric inpatient population transitioning to skilled nursing facilities (SNF).
METHODS - Health literacy, depression, and cognition were assessed via the Brief Health Literacy Screen (BHLS), Geriatric Depression Scale 5-item (GDS) and Brief Interview for Mental Status (BIMS), respectively. Multivariable logistic regression assessed the association between BHLS score and incontinence by: (1) nursing-reported urinary incontinence during hospitalization; and (2) patient self-reported "bladder accidents" in the post-enrollment study interview.
RESULTS - A total of 1556 hospitalized patients aged 65 and older met inclusion criteria, of whom 922 (59.3%) were women and 1480 had available BHLS scores. A total of 464 (29.8%) and 515 (33.1%) patients had nursing-reported and self-reported urinary incontinence, respectively. Nursing-reported incontinence was significantly associated with lower BHLS (ie, poorer health literacy) (aOR 0.93, 95%CI 0.89-0.99) and BIMS (ie, poorer cognition) (aOR 0.90, 95%CI 0.83-0.97) scores and need for assistance with toileting (aOR 7.08, 95%CI 2.16-23.21). Patient-reported incontinence was significantly associated with female sex (aOR 1.62, 95%CI 1.19-2.21), increased GDS score (ie, greater likelihood of depression) (aOR 1.22, 95%CI 1.10-1.36) and need for assistance with toileting (aOR 2.46, 95%CI 1.26-4.79).
CONCLUSIONS - Poorer health literacy and cognition are independently associated with an increased likelihood of nursing-reported urinary incontinence among geriatric inpatients transitioning to SNF. Practitioners should consider assessment of health literacy and cognition in frail patients at risk for urinary incontinence and that patient and nursing assessment may be required to capture the diagnosis.
© 2017 Wiley Periodicals, Inc.
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MeSH Terms
Impact of a National Guideline on Antibiotic Selection for Hospitalized Pneumonia.
Williams DJ, Hall M, Gerber JS, Neuman MI, Hersh AL, Brogan TV, Parikh K, Mahant S, Blaschke AJ, Shah SS, Grijalva CG, Pediatric Research in Inpatient Settings Network
(2017) Pediatrics 139:
MeSH Terms: Adolescent, Anti-Bacterial Agents, Child, Child, Preschool, Databases, Factual, Female, Guideline Adherence, Hospitals, Pediatric, Humans, Infant, Inpatients, Male, Pneumonia
Show Abstract · Added July 27, 2018
BACKGROUND - We evaluated the impact of the 2011 Pediatric Infectious Diseases Society/Infectious Diseases Society of America pneumonia guideline and hospital-level implementation efforts on antibiotic prescribing for children hospitalized with pneumonia.
METHODS - We assessed inpatient antibiotic prescribing for pneumonia at 28 children's hospitals between August 2009 and March 2015. Each hospital was also surveyed regarding local implementation efforts targeting antibiotic prescribing and organizational readiness to adopt guideline recommendations. To estimate guideline impact, we used segmented linear regression to compare the proportion of children receiving penicillins in March 2015 with the expected proportion at this same time point had the guideline not been published based on a projection of a preguideline trend. A similar approach was used to estimate the short-term (6-month) impact of local implementation efforts. The correlations between organizational readiness and the impact of the guideline were estimated by using Pearson's correlation coefficient.
RESULTS - Before guideline publication, penicillin prescribing was rare (<10%). After publication, an absolute increase in penicillin use was observed (27.6% [95% confidence interval: 23.7%-31.5%]) by March 2015. Among hospitals with local implementation efforts ( = 20, 71%), the median increase was 29.5% (interquartile range: 19.6%-39.1%) compared with 20.1% (interquartile rage: 9.5%-44.5%) among hospitals without such activities ( = .51). The independent, short-term impact of local implementation efforts was similar in magnitude to that of the national guideline. Organizational readiness was not correlated with prescribing changes.
CONCLUSIONS - The publication of the Pediatric Infectious Diseases Society/Infectious Diseases Society of America guideline was associated with sustained increases in the use of penicillins for children hospitalized with pneumonia. Local implementation efforts may have enhanced guideline adoption and appeared more relevant than hospitals' organizational readiness to change.
Copyright © 2017 by the American Academy of Pediatrics.
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Acute Kidney Injury Incidence in Noncritically Ill Hospitalized Children, Adolescents, and Young Adults: A Retrospective Observational Study.
McGregor TL, Jones DP, Wang L, Danciu I, Bridges BC, Fleming GM, Shirey-Rice J, Chen L, Byrne DW, Van Driest SL
(2016) Am J Kidney Dis 67: 384-90
MeSH Terms: Acute Kidney Injury, Adolescent, Child, Child, Preschool, Cohort Studies, Creatinine, Female, Hospital Mortality, Humans, Incidence, Infant, Inpatients, Kidney Function Tests, Length of Stay, Male, Retrospective Studies, Risk Factors, Severity of Illness Index, Tertiary Care Centers, Time Factors, United States, Young Adult
Show Abstract · Added April 11, 2017
BACKGROUND - Acute kidney injury (AKI) has been characterized in high-risk pediatric hospital inpatients, in whom AKI is frequent and associated with increased mortality, morbidity, and length of stay. The incidence of AKI among patients not requiring intensive care is unknown.
STUDY DESIGN - Retrospective cohort study.
SETTING & PARTICIPANTS - 13,914 noncritical admissions during 2011 and 2012 at our tertiary referral pediatric hospital were evaluated. Patients younger than 28 days or older than 21 years of age or with chronic kidney disease (CKD) were excluded. Admissions with 2 or more serum creatinine measurements were evaluated.
FACTORS - Demographic features, laboratory measurements, medication exposures, and length of stay.
OUTCOME - AKI defined as increased serum creatinine level in accordance with KDIGO (Kidney Disease: Improving Global Outcomes) criteria. Based on time of admission, time interval requirements were met in 97% of cases, but KDIGO time window criteria were not strictly enforced to allow implementation using clinically obtained data.
RESULTS - 2 or more creatinine measurements (one baseline before or during admission and a second during admission) in 2,374 of 13,914 (17%) patients allowed for AKI evaluation. A serum creatinine difference ≥0.3mg/dL or ≥1.5 times baseline was seen in 722 of 2,374 (30%) patients. A minimum of 5% of all noncritical inpatients without CKD in pediatric wards have an episode of AKI during routine hospital admission.
LIMITATIONS - Urine output, glomerular filtration rate, and time interval criteria for AKI were not applied secondary to study design and available data. The evaluated cohort was restricted to patients with 2 or more clinically obtained serum creatinine measurements, and baseline creatinine level may have been measured after the AKI episode.
CONCLUSIONS - AKI occurs in at least 5% of all noncritically ill hospitalized children, adolescents, and young adults without known CKD. Physicians should increase their awareness of AKI and improve surveillance strategies with serum creatinine measurements in this population so that exacerbating factors such as nephrotoxic medication exposures may be modified as indicated.
Copyright © 2016 National Kidney Foundation, Inc. Published by Elsevier Inc. All rights reserved.
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22 MeSH Terms
Predictors of health care system and physician distrust in hospitalized cardiac patients.
Gupta C, Bell SP, Schildcrout JS, Fletcher S, Goggins KM, Kripalani S, Vanderbilt Inpatient Cohort Study (VICS)
(2014) J Health Commun 19 Suppl 2: 44-60
MeSH Terms: Acute Coronary Syndrome, Adaptation, Psychological, Adult, Aged, Attitude to Health, Female, Health Literacy, Heart Failure, Humans, Inpatients, Male, Middle Aged, Multivariate Analysis, Physician-Patient Relations, Prospective Studies, Social Support, Trust
Show Abstract · Added January 20, 2015
Trusting relationships among patients, physicians, and the health care system is important in encouraging self-care behaviors in cardiovascular patients. This study aimed to assess the prevalence of health care system and physician distrust in this population, compare the 2 forms of distrust, and describe the demographic, socioeconomic, and psychosocial predictors of high distrust. A total of 1,232 hospitalized adults with acute coronary syndrome or heart failure were enrolled in a prospective, observational study assessing health care system distrust and physician distrust. High health care system distrust (35%) was observed across the population, with lower levels of interpersonal physician distrust (16%). In a multivariate analysis, poor social support and coping skills were strong predictors of both health care system (p=.026, p=.003) and physician distrust (p<.001, p=.006). Individuals with low or marginal health literacy had a higher likelihood of physician distrust (p<.001), but no relation was found between health literacy and health care system distrust. In conclusion, distrust is common among acutely ill cardiac patients. Those with low social support and low coping skills are more distrusting of physicians and the health care system.
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17 MeSH Terms
Health literacy, numeracy, and other characteristics associated with hospitalized patients' preferences for involvement in decision making.
Goggins KM, Wallston KA, Nwosu S, Schildcrout JS, Castel L, Kripalani S, Vanderbilt Inpatient Cohort Study (VICS)
(2014) J Health Commun 19 Suppl 2: 29-43
MeSH Terms: Adult, Aged, Attitude to Health, Cardiovascular Diseases, Educational Status, Female, Health Literacy, Humans, Inpatients, Male, Mathematical Concepts, Middle Aged, Multivariate Analysis, Patient Participation, Patient Preference, Prospective Studies, Sex Factors, Social Support, Trust
Show Abstract · Added January 20, 2015
Little research has examined the association of health literacy and numeracy with patients' preferred involvement in the problem-solving and decision-making process in the hospital. Using a sample of 1,249 patients hospitalized with cardiovascular disease from the Vanderbilt Inpatient Cohort Study (VICS), we assessed patients' preferred level of involvement using responses to two scenarios of differing symptom severity from the Problem-Solving Decision-Making Scale. Using multivariable modeling, we determined the relationship of health literacy, subjective numeracy, and other patient characteristics with preferences for involvement in decisions, and how this differed by scenario. The authors found that patients with higher levels of health literacy desired more participation in the problem-solving and decision-making process, as did patients with higher subjective numeracy skills, greater educational attainment, female gender, less perceived social support, or greater health care system distrust (p<.05 for each predictor in multivariable models). Patients also preferred to participate more in the decision-making process when the hypothetical symptom they were experiencing was less severe (i.e., they deferred more to their physician when the hypothetical symptom was more severe). These findings underscore the role that patient characteristics, especially health literacy and numeracy, play in decisional preferences among hospitalized patients.
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19 MeSH Terms
Association between statin use at admission to inpatient rehabilitation and functional status at discharge among older patients.
Morandi A, Girard TD, Shintani A, Turco R, Guerini F, Torpilliesi T, Gentile S, Trabucchi M, Bellelli G
(2014) Rejuvenation Res 17: 490-5
MeSH Terms: Activities of Daily Living, Aged, Aged, 80 and over, Comorbidity, Female, Hospitalization, Humans, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Inpatients, Linear Models, Male, Multivariate Analysis, Muscles, Patient Admission, Patient Discharge, Recovery of Function, Rehabilitation, Retrospective Studies
Show Abstract · Added September 23, 2015
The effect of statins on functional status in older patients is unclear. Statins might carry a deleterious effect on muscle function leading to myopathy and therefore affecting functional recovery. We evaluated the relationship between statin exposure at in-hospital rehabilitation admission and functional outcome at discharge. This was a retrospective cohort study of older patients 70 years and older consecutively admitted to an in-hospital rehabilitation after an acute hospitalization. Statin exposure was measured at the time of rehabilitation admission. Functional status was defined with the Barthel Index (BI) score at the time of discharge. A multi-variable linear regression model was used to evaluate the association between statin exposure and functional status at discharge adjusting for potential confounders through a propensity score for statin exposure. A total of 2435 patients were included. The cohort had a mean age of 81.1 years. Of these 9% (n=220) were on statins at the time of admission. In the multi-variable analysis, the use of statins at the time of admission was independently associated with an improved functional status at discharge (point estimate 5.2; 95% confidence interval 1.5-8.9; p<0.01) after adjusting for relevant confounders. Patients who were receiving statins at the time of admission had a BI score 5 points higher compared to those who were not receiving statins. The use of statins was overall safe in a group of co-morbid older patients undergoing rehabilitation training after an acute hospitalization. Additionally, a possible benefit was found given the positive association between statin use and higher functional status at discharge.
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18 MeSH Terms
Patterns of treatment and associated short-term outcomes of unruptured intracranial aneurysms in children.
Asaithambi G, Adil MM, Shah KM, Jordan LC, Qureshi AI
(2014) Childs Nerv Syst 30: 1697-700
MeSH Terms: Adolescent, Cerebral Hemorrhage, Child, Databases, Factual, Endovascular Procedures, Female, Humans, Inpatients, Intracranial Aneurysm, Male, Microsurgery, Postoperative Complications, Retrospective Studies, Subarachnoid Hemorrhage, Treatment Outcome, Young Adult
Show Abstract · Added March 24, 2020
BACKGROUND - The rates and outcomes of treatments for intracranial aneurysms have not been exclusively determined within the pediatric population. We determined the rates of endovascular and microsurgical treatments for unruptured intracranial aneurysms (UIA) and associated rates of favorable outcome in patients aged <18 years.
METHODS - We analyzed data obtained as part of the Kids' Inpatient Database between 2003 and 2009 with primary diagnosis of UIA. Patients undergoing endovascular treatment were compared to those undergoing microsurgical treatment. We determined rates of intracerebral hemorrhage, subarachnoid hemorrhage, neurological complications, and favorable outcome.
RESULTS - There were 818 cases of UIA during the study period. A total of 111 patients (mean age 14 ± 6 years, 37.6 % female) underwent microsurgical treatment, and another 200 patients (mean age 13 ± 7 years, 42.5 % female) underwent endovascular treatment. A high rate of favorable outcome was observed in patients who received either treatment (microsurgical treatment 87.7 % versus endovascular treatment 91.6 %, p = 0.4). There was a trend towards a significantly shorter mean hospitalization stay among those who received endovascular treatment compared with microsurgical treatment (6 ± 12 versus 9 ± 11 days, p = 0.06). There was a significant trend towards higher utilization of endovascular treatment as opposed to microsurgical treatment from 2003 to 2009 (p = 0.02).
CONCLUSIONS - Although outcomes except for length of stay were comparable between endovascular treatment and microsurgical treatment patients, there was a trend towards higher utilization of endovascular treatment among children with UIAs from 2003 to 2009.
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Determinants of health after hospital discharge: rationale and design of the Vanderbilt Inpatient Cohort Study (VICS).
Meyers AG, Salanitro A, Wallston KA, Cawthon C, Vasilevskis EE, Goggins KM, Davis CM, Rothman RL, Castel LD, Donato KM, Schnelle JF, Bell SP, Schildcrout JS, Osborn CY, Harrell FE, Kripalani S
(2014) BMC Health Serv Res 14: 10
MeSH Terms: Acute Coronary Syndrome, Aged, Continuity of Patient Care, Female, Health Literacy, Health Status, Heart Failure, Humans, Inpatients, Male, Middle Aged, Patient Discharge, Patient Outcome Assessment, Prospective Studies, Quality of Health Care, Self Care, Severity of Illness Index, Social Determinants of Health, Social Support
Show Abstract · Added March 2, 2014
BACKGROUND - The period following hospital discharge is a vulnerable time for patients when errors and poorly coordinated care are common. Suboptimal care transitions for patients admitted with cardiovascular conditions can contribute to readmission and other adverse health outcomes. Little research has examined the role of health literacy and other social determinants of health in predicting post-discharge outcomes.
METHODS - The Vanderbilt Inpatient Cohort Study (VICS), funded by the National Institutes of Health, is a prospective longitudinal study of 3,000 patients hospitalized with acute coronary syndromes or acute decompensated heart failure. Enrollment began in October 2011 and is planned through October 2015. During hospitalization, a set of validated demographic, cognitive, psychological, social, behavioral, and functional measures are administered, and health status and comorbidities are assessed. Patients are interviewed by phone during the first week after discharge to assess the quality of hospital discharge, communication, and initial medication management. At approximately 30 and 90 days post-discharge, interviewers collect additional data on medication adherence, social support, functional status, quality of life, and health care utilization. Mortality will be determined with up to 3.5 years follow-up. Statistical models will examine hypothesized relationships of health literacy and other social determinants on medication management, functional status, quality of life, utilization, and mortality. In this paper, we describe recruitment, eligibility, follow-up, data collection, and analysis plans for VICS, as well as characteristics of the accruing patient cohort.
DISCUSSION - This research will enhance understanding of how health literacy and other patient factors affect the quality of care transitions and outcomes after hospitalization. Findings will help inform the design of interventions to improve care transitions and post-discharge outcomes.
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19 MeSH Terms
Flash mob research: a single-day, multicenter, resident-directed study of respiratory rate.
Semler MW, Stover DG, Copland AP, Hong G, Johnson MJ, Kriss MS, Otepka H, Wang L, Christman BW, Rice TW
(2013) Chest 143: 1740-1744
MeSH Terms: Biomedical Research, Chi-Square Distribution, Data Collection, Female, Humans, Inpatients, Internal Medicine, Internship and Residency, Male, Prospective Studies, Respiratory Rate, Statistics, Nonparametric, United States
Show Abstract · Added February 19, 2015
BACKGROUND - Vital signs are critical data in the care of hospitalized patients, but the accuracy with which respiratory rates are recorded in this population remains uncertain. We used a novel flash mob research approach to evaluate the accuracy of recorded respiratory rates in inpatients.
METHODS - This was a single-day, resident-led, prospective observational study of recorded vs directly observed vital signs in nonventilated patients not in the ICU on internal medicine teaching services at six large tertiary-care centers across the United States.
RESULTS - Among the 368 inpatients included, the median respiratory rate was 16 breaths/min for the directly observed values and 18 breaths/min for the recorded values, with a median difference of 2 breaths/min (P < .001). Respiratory rates of 18 or 20 breaths/min accounted for 71.8% (95% CI, 67.1%-76.4%) of the recorded values compared with 13.0% (95% CI, 9.5%-16.5%) of the directly observed measurements. For individual patients, there was less agreement between the recorded and the directly observed respiratory rate compared with pulse rate.
CONCLUSIONS - Among hospitalized patients across the United States, recorded respiratory rates are higher than directly observed measurements and are significantly more likely to be 18 or 20 breaths/min.
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13 MeSH Terms