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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 404

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Cryo-EM structure of human type-3 inositol triphosphate receptor reveals the presence of a self-binding peptide that acts as an antagonist.
Azumaya CM, Linton EA, Risener CJ, Nakagawa T, Karakas E
(2020) J Biol Chem 295: 1743-1753
MeSH Terms: Binding Sites, Calcium Signaling, Cryoelectron Microscopy, Humans, Inositol 1,4,5-Trisphosphate, Inositol 1,4,5-Trisphosphate Receptors, Models, Molecular, Peptides, Protein Conformation
Added March 3, 2020
0 Communities
2 Members
0 Resources
9 MeSH Terms
TBCRC 032 IB/II Multicenter Study: Molecular Insights to AR Antagonist and PI3K Inhibitor Efficacy in Patients with AR Metastatic Triple-Negative Breast Cancer.
Lehmann BD, Abramson VG, Sanders ME, Mayer EL, Haddad TC, Nanda R, Van Poznak C, Storniolo AM, Nangia JR, Gonzalez-Ericsson PI, Sanchez V, Johnson KN, Abramson RG, Chen SC, Shyr Y, Arteaga CL, Wolff AC, Pietenpol JA, Translational Breast Cancer Research Consortium
(2020) Clin Cancer Res 26: 2111-2123
MeSH Terms: Androgen Receptor Antagonists, Antineoplastic Combined Chemotherapy Protocols, Class I Phosphatidylinositol 3-Kinases, Female, Humans, Imidazoles, Middle Aged, Neoplasm Metastasis, Oxazepines, Phenylthiohydantoin, Protein Kinase Inhibitors, Receptors, Androgen, Survival Rate, Triple Negative Breast Neoplasms
Added March 30, 2020
0 Communities
1 Members
0 Resources
14 MeSH Terms
Metabolic Labeling of Inositol Phosphates and Phosphatidylinositols in Yeast and Mammalian Cells.
Hale AT, Clarke BP, York JD
(2020) Methods Mol Biol 2091: 83-92
MeSH Terms: Animals, Biochemical Phenomena, COS Cells, Cell Line, Chlorocebus aethiops, HT29 Cells, HeLa Cells, Humans, Inositol Phosphates, Phosphatidylinositols, Saccharomyces cerevisiae, Signal Transduction
Added March 30, 2020
0 Communities
1 Members
0 Resources
12 MeSH Terms
Bacterial Pathogens Hijack the Innate Immune Response by Activation of the Reverse Transsulfuration Pathway.
Gobert AP, Latour YL, Asim M, Finley JL, Verriere TG, Barry DP, Milne GL, Luis PB, Schneider C, Rivera ES, Lindsey-Rose K, Schey KL, Delgado AG, Sierra JC, Piazuelo MB, Wilson KT
(2019) mBio 10:
MeSH Terms: Animals, Bacteria, Gene Silencing, Helicobacter pylori, Histones, Humans, Immune Evasion, Immunity, Innate, Immunoglobulins, Macrophages, Male, Metabolic Networks and Pathways, Mice, Mice, Inbred C57BL, Nitric Oxide Synthase Type II, Phosphatidylinositol 3-Kinases, Polyamines, RAW 264.7 Cells, Spermidine, Spermine, Sulfur, Transcription Factors
Added November 1, 2019
0 Communities
2 Members
0 Resources
22 MeSH Terms
A synthetic biological approach to reconstitution of inositide signaling pathways in bacteria.
Clarke BP, Logeman BL, Hale AT, Luka Z, York JD
(2019) Adv Biol Regul 73: 100637
MeSH Terms: Escherichia coli, Phosphatidylinositols, Signal Transduction, Synthetic Biology
Added March 30, 2020
0 Communities
1 Members
0 Resources
4 MeSH Terms
Akt Signaling in Macrophage Polarization, Survival, and Atherosclerosis.
Linton MF, Moslehi JJ, Babaev VR
(2019) Int J Mol Sci 20:
MeSH Terms: Animals, Apoptosis, Atherosclerosis, Blood Cells, Cell Survival, Humans, Macrophage Activation, Macrophages, Phosphatidylinositol 3-Kinases, Protein Isoforms, Proto-Oncogene Proteins c-akt, Signal Transduction
Added November 12, 2019
0 Communities
1 Members
0 Resources
12 MeSH Terms
Direct Activation of Human MLKL by a Select Repertoire of Inositol Phosphate Metabolites.
McNamara DE, Dovey CM, Hale AT, Quarato G, Grace CR, Guibao CD, Diep J, Nourse A, Cai CR, Wu H, Kalathur RC, Green DR, York JD, Carette JE, Moldoveanu T
(2019) Cell Chem Biol 26: 863-877.e7
MeSH Terms: Animals, Cell Survival, HT29 Cells, Humans, Inositol Phosphates, Protein Kinases, Sf9 Cells, Spodoptera
Added March 30, 2020
0 Communities
1 Members
0 Resources
8 MeSH Terms
Multiple mechanisms underlie increased cardiac late sodium current.
Kroncke BM, Yang T, Roden DM
(2019) Heart Rhythm 16: 1091-1097
MeSH Terms: Action Potentials, Animals, CHO Cells, Cardiac Conduction System Disease, Cricetinae, Cricetulus, Genotype, Humans, Induced Pluripotent Stem Cells, Kidney, Long QT Syndrome, Myocytes, Cardiac, NAV1.5 Voltage-Gated Sodium Channel, Phenotype, Phosphatidylinositol 3-Kinases
Added March 26, 2019
0 Communities
3 Members
0 Resources
15 MeSH Terms
Crystallographic and kinetic analyses of human IPMK reveal disordered domains modulate ATP binding and kinase activity.
Seacrist CD, Blind RD
(2018) Sci Rep 8: 16672
MeSH Terms: Adenosine Triphosphate, Crystallography, Humans, Inositol Phosphates, Kinetics, Phosphorylation, Phosphotransferases (Alcohol Group Acceptor), Protein Binding, Protein Structure, Secondary, Signal Transduction
Added January 19, 2019
0 Communities
1 Members
0 Resources
10 MeSH Terms
Signaling through non-membrane nuclear phosphoinositide binding proteins in human health and disease.
Bryant JM, Blind RD
(2019) J Lipid Res 60: 299-311
MeSH Terms: Animals, Disease, Health, Humans, Phosphatidylinositols, Receptors, Cytoplasmic and Nuclear, Signal Transduction
Added January 19, 2019
0 Communities
1 Members
0 Resources
7 MeSH Terms