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Results: 1 to 10 of 34

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Neutralizing human antibodies prevent Zika virus replication and fetal disease in mice.
Sapparapu G, Fernandez E, Kose N, Bin Cao , Fox JM, Bombardi RG, Zhao H, Nelson CA, Bryan AL, Barnes T, Davidson E, Mysorekar IU, Fremont DH, Doranz BJ, Diamond MS, Crowe JE
(2016) Nature 540: 443-447
MeSH Terms: Africa, Americas, Animals, Antibodies, Monoclonal, Antibodies, Neutralizing, Antibodies, Viral, Antibody Specificity, Asia, B-Lymphocytes, Disease Models, Animal, Epitope Mapping, Female, Fetal Diseases, Fetus, Humans, Infectious Disease Transmission, Vertical, Male, Mice, Models, Molecular, Placenta, Pregnancy, Protein Multimerization, Survival Rate, Viral Proteins, Viral Vaccines, Virus Replication, Zika Virus, Zika Virus Infection
Show Abstract · Added April 13, 2017
Zika virus (ZIKV) is an emerging mosquito-transmitted flavivirus that can cause severe disease, including congenital birth defects during pregnancy. To develop candidate therapeutic agents against ZIKV, we isolated a panel of human monoclonal antibodies from subjects that were previously infected with ZIKV. We show that a subset of antibodies recognize diverse epitopes on the envelope (E) protein and exhibit potent neutralizing activity. One of the most inhibitory antibodies, ZIKV-117, broadly neutralized infection of ZIKV strains corresponding to African and Asian-American lineages. Epitope mapping studies revealed that ZIKV-117 recognized a unique quaternary epitope on the E protein dimer-dimer interface. We evaluated the therapeutic efficacy of ZIKV-117 in pregnant and non-pregnant mice. Monoclonal antibody treatment markedly reduced tissue pathology, placental and fetal infection, and mortality in mice. Thus, neutralizing human antibodies can protect against maternal-fetal transmission, infection and disease, and reveal important determinants for structure-based rational vaccine design efforts.
0 Communities
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28 MeSH Terms
Mom knows best: the universality of maternal microbial transmission.
Funkhouser LJ, Bordenstein SR
(2013) PLoS Biol 11: e1001631
MeSH Terms: Animals, Breast Feeding, Female, Humans, Infant, Newborn, Infectious Disease Transmission, Vertical, Maternal Exposure, Microbiota, Pregnancy
Added October 8, 2015
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9 MeSH Terms
Clinical and genetic determinants of plasma nevirapine exposure following an intrapartum dose to prevent mother-to-child HIV transmission.
Vardhanabhuti S, Acosta EP, Ribaudo HJ, Severe P, Lalloo U, Kumarasamy N, Taulo F, Kabanda J, Oneko O, Ive P, Sambarey P, Chan ES, Hitti J, Hong F, McMahon D, Haas DW, A5207 ACTG Study Team
(2013) J Infect Dis 208: 662-71
MeSH Terms: Adult, Anti-HIV Agents, Aryl Hydrocarbon Hydroxylases, Chemoprevention, Cytochrome P-450 CYP2B6, Female, HIV Infections, Humans, Infant, Newborn, Infectious Disease Transmission, Vertical, Inhibitory Concentration 50, Male, Metabolic Clearance Rate, Nevirapine, Oxidoreductases, N-Demethylating, Plasma, Polymorphism, Genetic, Pregnancy, Time Factors, Young Adult
Added March 13, 2015
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20 MeSH Terms
The HIV Epidemic: High-Income Countries.
Vermund SH, Leigh-Brown AJ
(2012) Cold Spring Harb Perspect Med 2: a007195
MeSH Terms: Alcohol Drinking, Developed Countries, Drug Resistance, Viral, Epidemics, Female, HIV Infections, Heterosexuality, Homosexuality, Male, Humans, Income, Infectious Disease Transmission, Vertical, Male, Molecular Epidemiology, Needle Sharing, Risk Factors, Substance Abuse, Intravenous, Transfusion Reaction, Unsafe Sex
Added March 5, 2014
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18 MeSH Terms
Cytomegalovirus infection.
Plosa EJ, Esbenshade JC, Fuller MP, Weitkamp JH
(2012) Pediatr Rev 33: 156-63; quiz 163
MeSH Terms: Antiviral Agents, Child, Cytomegalovirus Infections, Cytomegalovirus Vaccines, Global Health, Humans, Immunocompromised Host, Infant, Infant, Newborn, Infectious Disease Transmission, Vertical, Postoperative Complications, Transplantation
Added February 27, 2014
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12 MeSH Terms
Relationship between maternal and neonatal Staphylococcus aureus colonization.
Jimenez-Truque N, Tedeschi S, Saye EJ, McKenna BD, Langdon W, Wright JP, Alsentzer A, Arnold S, Saville BR, Wang W, Thomsen I, Creech CB
(2012) Pediatrics 129: e1252-9
MeSH Terms: Age Factors, Bacteriological Techniques, Cohort Studies, Cross-Sectional Studies, Female, Humans, Infant, Newborn, Infectious Disease Transmission, Vertical, Male, Methicillin-Resistant Staphylococcus aureus, Nasal Mucosa, Odds Ratio, Prospective Studies, Staphylococcal Infections, Tennessee, Vagina
Added February 3, 2014
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16 MeSH Terms
Improving retention in the early infant diagnosis of HIV program in rural Mozambique by better service integration.
Ciampa PJ, Burlison JR, Blevins M, Sidat M, Moon TD, Rothman RL, Vermund SH
(2011) J Acquir Immune Defic Syndr 58: 115-9
MeSH Terms: Adult, Anti-HIV Agents, Delivery of Health Care, Drug Therapy, Combination, Female, HIV Infections, Humans, Infant, Newborn, Infectious Disease Transmission, Vertical, Lamivudine, Mozambique, Nevirapine, Pregnancy, Retrospective Studies, Rural Population, Young Adult, Zidovudine
Added December 10, 2013
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17 MeSH Terms
Adherence to perinatal group B streptococcal prevention guidelines.
Goins WP, Talbot TR, Schaffner W, Edwards KM, Craig AS, Schrag SJ, Van Dyke MK, Griffin MR
(2010) Obstet Gynecol 115: 1217-1224
MeSH Terms: Adult, Antibiotic Prophylaxis, Female, Guideline Adherence, Humans, Infant, Newborn, Infectious Disease Transmission, Vertical, Medical Audit, Perinatal Care, Practice Guidelines as Topic, Pregnancy, Pregnancy Complications, Infectious, Streptococcal Infections, Streptococcus agalactiae, Tennessee, Young Adult
Added December 10, 2013
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16 MeSH Terms
Early neurologic abnormalities associated with human T-cell lymphotropic virus type 1 infection in a cohort of Peruvian children.
Kendall EA, González E, Espinoza I, Tipismana M, Verdonck K, Clark D, Vermund SH, Gotuzzo E
(2009) J Pediatr 155: 700-6
MeSH Terms: Adolescent, Age Distribution, Age of Onset, Case-Control Studies, Child, Child, Preschool, Cohort Studies, Confidence Intervals, Female, HTLV-I Infections, Human T-lymphotropic virus 1, Humans, Infectious Disease Transmission, Vertical, Male, Neurologic Examination, Odds Ratio, Paraparesis, Paraparesis, Tropical Spastic, Peru, Prevalence, Probability, Risk Assessment, Severity of Illness Index, Sex Distribution, Spinal Cord Diseases, Time Factors, Urination Disorders
Added March 5, 2014
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27 MeSH Terms
A randomized control trial of an Ultra-Short zidovudine regimen in the prevention of perinatal HIV transmission in rural Zimbabwe.
Thistle P, Gottesman M, Pilon R, Glazier RH, Arbess G, Phillips E, Wald RL, Chitsike I, Simor A, Chipato T, Silverman M
(2004) Cent Afr J Med 50: 79-84
MeSH Terms: Adult, Double-Blind Method, Female, HIV Infections, Humans, Infant, Newborn, Infectious Disease Transmission, Vertical, Perinatal Care, Pregnancy, Zidovudine, Zimbabwe
Added March 30, 2020
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MeSH Terms