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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 31

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Improving Loop Modeling of the Antibody Complementarity-Determining Region 3 Using Knowledge-Based Restraints.
Finn JA, Koehler Leman J, Willis JR, Cisneros A, Crowe JE, Meiler J
(2016) PLoS One 11: e0154811
MeSH Terms: Algorithms, Cluster Analysis, Complementarity Determining Regions, Immunoglobulin Heavy Chains, Immunoglobulin Variable Region, Models, Molecular, Protein Conformation, Structure-Activity Relationship
Added April 8, 2017
1 Communities
2 Members
0 Resources
8 MeSH Terms
Low frequency of broadly neutralizing HIV antibodies during chronic infection even in quaternary epitope targeting antibodies containing large numbers of somatic mutations.
Hicar MD, Chen X, Kalams SA, Sojar H, Landucci G, Forthal DN, Spearman P, Crowe JE
(2016) Mol Immunol 70: 94-103
MeSH Terms: Antibodies, Monoclonal, Antibodies, Neutralizing, B-Lymphocytes, Cell Separation, Enzyme-Linked Immunosorbent Assay, Epitopes, Flow Cytometry, Genes, Immunoglobulin, HIV Antibodies, HIV Infections, Humans, Immunoglobulin Heavy Chains, Immunoglobulin Variable Region, Mutation, env Gene Products, Human Immunodeficiency Virus
Added January 26, 2016
0 Communities
1 Members
0 Resources
15 MeSH Terms
Tissue-specific expressed antibody variable gene repertoires.
Briney BS, Willis JR, Finn JA, McKinney BA, Crowe JE
(2014) PLoS One 9: e100839
MeSH Terms: Adolescent, Adult, Antibodies, Bone Marrow, Cluster Analysis, Complementarity Determining Regions, DNA, Demography, Gene Expression Regulation, Germ Cells, High-Throughput Nucleotide Sequencing, Humans, Immunoglobulin Variable Region, Lymphoid Tissue, Middle Aged, Mucous Membrane, Mutation, Mutation Rate, Organ Specificity, RNA, Somatic Hypermutation, Immunoglobulin, V(D)J Recombination, Young Adult
Added February 2, 2015
0 Communities
1 Members
0 Resources
23 MeSH Terms
B lymphocyte "original sin" in the bone marrow enhances islet autoreactivity in type 1 diabetes-prone nonobese diabetic mice.
Henry-Bonami RA, Williams JM, Rachakonda AB, Karamali M, Kendall PL, Thomas JW
(2013) J Immunol 190: 5992-6003
MeSH Terms: Amino Acid Sequence, Animals, Autoantigens, Autoimmunity, B-Lymphocytes, Bone Marrow Cells, Cell Separation, Diabetes Mellitus, Type 1, Enzyme-Linked Immunosorbent Assay, Flow Cytometry, Immunoglobulin Variable Region, Insulin, Islets of Langerhans, Lymphocyte Activation, Mice, Mice, Inbred NOD, Molecular Sequence Data, Self Tolerance
Added January 23, 2014
3 Communities
3 Members
0 Resources
18 MeSH Terms
Reversion of somatic mutations of the respiratory syncytial virus-specific human monoclonal antibody Fab19 reveal a direct relationship between association rate and neutralizing potency.
Bates JT, Keefer CJ, Utley TJ, Correia BE, Schief WR, Crowe JE
(2013) J Immunol 190: 3732-9
MeSH Terms: Amino Acid Sequence, Antibodies, Monoclonal, Antibodies, Neutralizing, Antibodies, Viral, Antibody Affinity, Antibody Specificity, Humans, Immunoglobulin Fab Fragments, Immunoglobulin Variable Region, Kinetics, Models, Molecular, Molecular Docking Simulation, Mutation, Neutralization Tests, Protein Binding, Protein Conformation, Recombinant Proteins, Respiratory Syncytial Virus, Human, Viral Fusion Proteins
Added March 7, 2014
0 Communities
1 Members
0 Resources
19 MeSH Terms
Frequency and genetic characterization of V(DD)J recombinants in the human peripheral blood antibody repertoire.
Briney BS, Willis JR, Hicar MD, Thomas JW, Crowe JE
(2012) Immunology 137: 56-64
MeSH Terms: Amino Acid Sequence, Antibodies, Antibody Formation, B-Lymphocytes, Base Sequence, Complementarity Determining Regions, Gene Frequency, Genetic Variation, High-Throughput Nucleotide Sequencing, Humans, Immunoglobulin Variable Region, Sequence Alignment, Sequence Analysis, DNA, V(D)J Recombination
Added November 6, 2013
1 Communities
1 Members
0 Resources
14 MeSH Terms
An insertion mutation that distorts antibody binding site architecture enhances function of a human antibody.
Krause JC, Ekiert DC, Tumpey TM, Smith PB, Wilson IA, Crowe JE
(2011) mBio 2: e00345-10
MeSH Terms: Animals, Antibodies, Monoclonal, Antibodies, Viral, Base Sequence, Binding Sites, Antibody, Cell Line, Female, Humans, Immunoglobulin Heavy Chains, Immunoglobulin Variable Region, Influenza A Virus, H1N1 Subtype, Influenza, Human, Mice, Mice, Inbred BALB C, Molecular Sequence Data, Mutagenesis, Insertional, Protein Binding, Protein Conformation
Added August 6, 2012
0 Communities
1 Members
0 Resources
18 MeSH Terms
Vkappa polymorphisms in NOD mice are spread throughout the entire immunoglobulin kappa locus and are shared by other autoimmune strains.
Henry RA, Kendall PL, Woodward EJ, Hulbert C, Thomas JW
(2010) Immunogenetics 62: 507-20
MeSH Terms: Amino Acid Substitution, Animals, Autoimmunity, B-Lymphocytes, Base Sequence, DNA Primers, Diabetes Mellitus, Type 1, Genes, Immunoglobulin Heavy Chain, Genes, Immunoglobulin Light Chain, Immunoglobulin Variable Region, Immunoglobulin kappa-Chains, Insulin, Mice, Mice, Inbred NOD, Mice, Transgenic, Molecular Sequence Data, Polymorphism, Genetic, Sequence Homology, Nucleic Acid, Species Specificity, T-Lymphocytes
Added December 10, 2013
2 Communities
2 Members
0 Resources
20 MeSH Terms
The human neonatal B cell response to respiratory syncytial virus uses a biased antibody variable gene repertoire that lacks somatic mutations.
Williams JV, Weitkamp JH, Blum DL, LaFleur BJ, Crowe JE
(2009) Mol Immunol 47: 407-14
MeSH Terms: Adult, Antibodies, Antibody Specificity, B-Lymphocytes, Cell Separation, Child, Complementarity Determining Regions, Flow Cytometry, Humans, Immunoglobulin Heavy Chains, Immunoglobulin Light Chains, Immunoglobulin Variable Region, Infant, Infant, Newborn, Lymphocyte Count, Mutagenesis, Insertional, Mutation, Respiratory Syncytial Viruses, Species Specificity
Added February 27, 2014
0 Communities
2 Members
0 Resources
19 MeSH Terms
Functional maturation of the human antibody response to rotavirus.
Kallewaard NL, McKinney BA, Gu Y, Chen A, Prasad BV, Crowe JE
(2008) J Immunol 180: 3980-9
MeSH Terms: Antibodies, Viral, Antigens, Viral, Binding Sites, Antibody, Capsid Proteins, Humans, Immunodominant Epitopes, Immunoglobulin D, Immunoglobulin Fab Fragments, Immunoglobulin Heavy Chains, Immunoglobulin Variable Region, Kinetics, Respiratory Syncytial Viruses, Rotavirus, Somatic Hypermutation, Immunoglobulin
Added August 6, 2012
0 Communities
1 Members
0 Resources
14 MeSH Terms