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High-Throughput Detection of Autoantigen-Specific B Cells Among Distinct Functional Subsets in Autoimmune Donors.
Joosse BA, Jackson JH, Cisneros A, Santhin AB, Smith SA, Moore DJ, Crofford LJ, Wilfong EM, Bonami RH
(2021) Front Immunol 12: 685718
MeSH Terms: Adult, Aged, Autoantibodies, Autoantigens, Autoimmune Diseases, B-Lymphocyte Subsets, B-Lymphocytes, Female, Humans, Immunoglobulin D, Immunoglobulin M, Leukocytes, Mononuclear, Male, Middle Aged, Tumor Necrosis Factor Receptor Superfamily, Member 7
Added July 23, 2021
0 Communities
1 Members
0 Resources
15 MeSH Terms
Healthy Donor Polyclonal IgMs Diminish B-Lymphocyte Autoreactivity, Enhance Regulatory T-Cell Generation, and Reverse Type 1 Diabetes in NOD Mice.
Wilson CS, Chhabra P, Marshall AF, Morr CV, Stocks BT, Hoopes EM, Bonami RH, Poffenberger G, Brayman KL, Moore DJ
(2018) Diabetes 67: 2349-2360
MeSH Terms: Animals, B-Lymphocytes, Diabetes Mellitus, Type 1, Immunoglobulin M, Mice, Mice, Inbred NOD, T-Lymphocytes, Regulatory
Added August 23, 2018
0 Communities
2 Members
0 Resources
7 MeSH Terms
Evidence for the Role of the Cecal Microbiome in Maintenance of Immune Regulation and Homeostasis.
Chhabra P, Spano AJ, Bowers D, Ren T, Moore DJ, Timko MP, Wu M, Brayman KL
(2018) Ann Surg 268: 541-549
MeSH Terms: Animals, Cecum, Diabetes Mellitus, Experimental, Diabetes Mellitus, Type 1, Female, Gastrointestinal Microbiome, Homeostasis, Humans, Immunoglobulin M, Mice, Mice, Inbred NOD
Added July 12, 2018
0 Communities
1 Members
0 Resources
11 MeSH Terms
Bruton's Tyrosine Kinase Is Not Essential for B Cell Survival beyond Early Developmental Stages.
Nyhoff LE, Clark ES, Barron BL, Bonami RH, Khan WN, Kendall PL
(2018) J Immunol 200: 2352-2361
MeSH Terms: Agammaglobulinaemia Tyrosine Kinase, Animals, Autoimmune Diseases, B-Lymphocyte Subsets, Cell Survival, Cells, Cultured, Immunoglobulin M, Mice, Mice, Inbred C57BL, Mice, Knockout, Receptors, Antigen, B-Cell, Signal Transduction
Added March 3, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
Distinct patterns of B-cell receptor signaling in non-Hodgkin lymphomas identified by single-cell profiling.
Myklebust JH, Brody J, Kohrt HE, Kolstad A, Czerwinski DK, Wälchli S, Green MR, Trøen G, Liestøl K, Beiske K, Houot R, Delabie J, Alizadeh AA, Irish JM, Levy R
(2017) Blood 129: 759-770
MeSH Terms: Agammaglobulinaemia Tyrosine Kinase, CD79 Antigens, Diagnosis, Differential, Flow Cytometry, Gene Expression Regulation, Neoplastic, Humans, Immunoglobulin M, Leukemia, Lymphocytic, Chronic, B-Cell, Lymphoma, Follicular, Lymphoma, Large B-Cell, Diffuse, Lymphoma, Mantle-Cell, Mitogen-Activated Protein Kinase 1, Mitogen-Activated Protein Kinase 3, Phospholipase C gamma, Phosphoproteins, Phosphorylation, Protein-Tyrosine Kinases, Proto-Oncogene Proteins c-akt, Receptors, Antigen, B-Cell, STAT1 Transcription Factor, STAT5 Transcription Factor, Signal Transduction, Single-Cell Analysis, Syk Kinase, p38 Mitogen-Activated Protein Kinases, src-Family Kinases
Added December 31, 2016
1 Communities
1 Members
0 Resources
26 MeSH Terms
Targeting Anti-Insulin B Cell Receptors Improves Receptor Editing in Type 1 Diabetes-Prone Mice.
Bonami RH, Thomas JW
(2015) J Immunol 195: 4730-41
MeSH Terms: Animals, Antibodies, Monoclonal, Autoantigens, Autoimmunity, B-Lymphocytes, DNA-Binding Proteins, Diabetes Mellitus, Type 1, Immune Tolerance, Immunoglobulin M, Immunoglobulin kappa-Chains, Immunomodulation, Insulin, Mice, Mice, Inbred C57BL, Mice, Inbred NOD, Molecular Sequence Data, Receptors, Antigen, B-Cell
Added April 1, 2016
2 Communities
1 Members
0 Resources
17 MeSH Terms
Reversing Tolerance in Isotype Switch-Competent Anti-Insulin B Lymphocytes.
Williams JM, Bonami RH, Hulbert C, Thomas JW
(2015) J Immunol 195: 853-64
MeSH Terms: Animals, Autoantibodies, Autoimmunity, B-Lymphocytes, CD40 Antigens, Diabetes Mellitus, Type 1, Immune Tolerance, Immunoglobulin G, Immunoglobulin M, Insulin, Insulin Antibodies, Lipopolysaccharides, Mice, Mice, Inbred C57BL, Mice, Transgenic, Molecular Sequence Data, VDJ Exons
Added December 4, 2015
2 Communities
2 Members
0 Resources
17 MeSH Terms
Reduced T cell-dependent humoral immune response in microsomal prostaglandin E synthase-1 null mice is mediated by nonhematopoietic cells.
Kojima F, Frolov A, Matnani R, Woodward JG, Crofford LJ
(2013) J Immunol 191: 4979-88
MeSH Terms: Animals, Arthritis, Experimental, Bone Marrow Transplantation, Cells, Cultured, Collagen, Female, Immunity, Humoral, Immunoglobulin G, Immunoglobulin M, Interferon-gamma, Interleukin-17, Interleukin-2, Interleukin-4, Intramolecular Oxidoreductases, Male, Mice, Mice, Inbred DBA, Mice, Knockout, Prostaglandin-E Synthases, T-Lymphocytes
Added January 21, 2015
0 Communities
1 Members
0 Resources
20 MeSH Terms
Early detection of NSCLC with scFv selected against IgM autoantibody.
Pedchenko T, Mernaugh R, Parekh D, Li M, Massion PP
(2013) PLoS One 8: e60934
MeSH Terms: Adenocarcinoma, Adenocarcinoma of Lung, Area Under Curve, Autoantibodies, Biomarkers, Tumor, Carcinoma, Non-Small-Cell Lung, Early Diagnosis, Female, Humans, Immunoglobulin M, Lung Neoplasms, Male, Peptide Library, ROC Curve, Single-Chain Antibodies
Added March 7, 2014
0 Communities
2 Members
0 Resources
15 MeSH Terms
Location and length distribution of somatic hypermutation-associated DNA insertions and deletions reveals regions of antibody structural plasticity.
Briney BS, Willis JR, Crowe JE
(2012) Genes Immun 13: 523-9
MeSH Terms: Binding Sites, High-Throughput Nucleotide Sequencing, Humans, INDEL Mutation, Immunoglobulin G, Immunoglobulin M, Protein Structure, Tertiary, Sequence Analysis, DNA, Somatic Hypermutation, Immunoglobulin
Added August 6, 2012
0 Communities
1 Members
0 Resources
9 MeSH Terms