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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 12

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Intrahepatic bile duct regeneration in mice does not require Hnf6 or Notch signaling through Rbpj.
Walter TJ, Vanderpool C, Cast AE, Huppert SS
(2014) Am J Pathol 184: 1479-88
MeSH Terms: Animals, Bile Ducts, Intrahepatic, Epithelial Cells, Hepatocyte Nuclear Factor 6, Hepatocytes, Imaging, Three-Dimensional, Immunoglobulin J Recombination Signal Sequence-Binding Protein, Immunohistochemistry, Keratin-19, Mice, Knockout, Plant Lectins, Portal Vein, Receptors, Notch, Regeneration, SOX9 Transcription Factor
Added May 27, 2014
0 Communities
1 Members
0 Resources
15 MeSH Terms
Program specificity for Ptf1a in pancreas versus neural tube development correlates with distinct collaborating cofactors and chromatin accessibility.
Meredith DM, Borromeo MD, Deering TG, Casey BH, Savage TK, Mayer PR, Hoang C, Tung KC, Kumar M, Shen C, Swift GH, Macdonald RJ, Johnson JE
(2013) Mol Cell Biol 33: 3166-79
MeSH Terms: Animals, Base Sequence, Cell Line, Chromatin, Consensus Sequence, DNA, Gene Expression Regulation, Developmental, Hepatocyte Nuclear Factor 3-beta, Humans, Immunoglobulin J Recombination Signal Sequence-Binding Protein, Mice, Mice, Transgenic, Neural Tube, Pancreas, Protein Binding, SOXB1 Transcription Factors, Transcription Factors
Added November 6, 2013
0 Communities
1 Members
0 Resources
17 MeSH Terms
Notch-mediated patterning and cell fate allocation of pancreatic progenitor cells.
Afelik S, Qu X, Hasrouni E, Bukys MA, Deering T, Nieuwoudt S, Rogers W, Macdonald RJ, Jensen J
(2012) Development 139: 1744-53
MeSH Terms: Animals, Cell Differentiation, Cells, Cultured, Chromatin Immunoprecipitation, Flow Cytometry, Homeodomain Proteins, Immunoglobulin J Recombination Signal Sequence-Binding Protein, Immunohistochemistry, Mice, Pancreas, Protein Binding, Real-Time Polymerase Chain Reaction, Receptors, Notch, Stem Cells
Added November 6, 2013
0 Communities
1 Members
0 Resources
14 MeSH Terms
Ongoing Notch signaling maintains phenotypic fidelity in the adult exocrine pancreas.
Kopinke D, Brailsford M, Pan FC, Magnuson MA, Wright CV, Murtaugh LC
(2012) Dev Biol 362: 57-64
MeSH Terms: Acinar Cells, Animals, Basic Helix-Loop-Helix Transcription Factors, Cell Differentiation, Histological Techniques, Homeodomain Proteins, Immunoglobulin J Recombination Signal Sequence-Binding Protein, Mice, Oligonucleotides, Pancreas, Exocrine, Phenotype, Receptors, Notch, Signal Transduction, Transcription Factor HES-1
Added October 19, 2012
5 Communities
2 Members
1 Resources
14 MeSH Terms
Notch-independent functions of CSL.
Johnson JE, Macdonald RJ
(2011) Curr Top Dev Biol 97: 55-74
MeSH Terms: Animals, Caenorhabditis elegans, Caenorhabditis elegans Proteins, DNA-Binding Proteins, Drosophila, Drosophila Proteins, Gene Expression Regulation, Humans, Immunoglobulin J Recombination Signal Sequence-Binding Protein, Models, Biological, Protein Binding, Receptors, Notch, Repressor Proteins, Signal Transduction, Transcription Factors, Transcription, Genetic
Added November 6, 2013
0 Communities
1 Members
0 Resources
16 MeSH Terms
Genetic interactions between hepatocyte nuclear factor-6 and Notch signaling regulate mouse intrahepatic bile duct development in vivo.
Vanderpool C, Sparks EE, Huppert KA, Gannon M, Means AL, Huppert SS
(2012) Hepatology 55: 233-43
MeSH Terms: Animals, Bile Ducts, Intrahepatic, Cell Lineage, Cholestasis, Gene Expression Regulation, Developmental, Hepatocyte Nuclear Factor 1-beta, Hepatocyte Nuclear Factor 6, Hepatocytes, Immunoglobulin J Recombination Signal Sequence-Binding Protein, Immunoglobulin kappa-Chains, Integrases, Mice, Mice, Inbred Strains, Mice, Knockout, Receptors, Notch, SOX9 Transcription Factor, Signal Transduction
Added December 5, 2013
3 Communities
2 Members
1 Resources
17 MeSH Terms
Defects in hepatic Notch signaling result in disruption of the communicating intrahepatic bile duct network in mice.
Sparks EE, Perrien DS, Huppert KA, Peterson TE, Huppert SS
(2011) Dis Model Mech 4: 359-67
MeSH Terms: Aging, Animals, Bile Ducts, Intrahepatic, Cell Communication, Immunoglobulin J Recombination Signal Sequence-Binding Protein, Mice, Mice, Knockout, Morphogenesis, Receptors, Notch, Signal Transduction, Tomography, X-Ray Computed
Added April 25, 2013
1 Communities
5 Members
0 Resources
11 MeSH Terms
Replacement of Rbpj with Rbpjl in the PTF1 complex controls the final maturation of pancreatic acinar cells.
Masui T, Swift GH, Deering T, Shen C, Coats WS, Long Q, Elsässer HP, Magnuson MA, MacDonald RJ
(2010) Gastroenterology 139: 270-80
MeSH Terms: Animals, Cell Differentiation, Gene Expression Regulation, Immunoglobulin J Recombination Signal Sequence-Binding Protein, Liver, Mice, Mice, Knockout, Pancreas, Exocrine, Phenotype, RNA, Messenger, Transcription Factors
Added November 6, 2013
3 Communities
2 Members
0 Resources
11 MeSH Terms
Neurog2 is a direct downstream target of the Ptf1a-Rbpj transcription complex in dorsal spinal cord.
Henke RM, Savage TK, Meredith DM, Glasgow SM, Hori K, Dumas J, MacDonald RJ, Johnson JE
(2009) Development 136: 2945-54
MeSH Terms: Animals, Base Sequence, Basic Helix-Loop-Helix Transcription Factors, Binding Sites, Cell Differentiation, Chick Embryo, Embryo, Mammalian, Enhancer Elements, Genetic, Gene Expression Regulation, Developmental, Humans, Immunoglobulin J Recombination Signal Sequence-Binding Protein, Mice, Mice, Inbred C57BL, Mice, Transgenic, Molecular Sequence Data, Multiprotein Complexes, Nerve Tissue Proteins, Signal Transduction, Spinal Cord, Transcription Factors, Transcription, Genetic
Added November 6, 2013
0 Communities
1 Members
0 Resources
21 MeSH Terms
A nonclassical bHLH Rbpj transcription factor complex is required for specification of GABAergic neurons independent of Notch signaling.
Hori K, Cholewa-Waclaw J, Nakada Y, Glasgow SM, Masui T, Henke RM, Wildner H, Martarelli B, Beres TM, Epstein JA, Magnuson MA, Macdonald RJ, Birchmeier C, Johnson JE
(2008) Genes Dev 22: 166-78
MeSH Terms: Animals, Basic Helix-Loop-Helix Transcription Factors, Cerebellum, Chick Embryo, Immunoglobulin J Recombination Signal Sequence-Binding Protein, Mice, Mutation, Neurons, Receptors, Notch, Signal Transduction, Spinal Cord, Transcription Factors, Transfection, gamma-Aminobutyric Acid
Added November 6, 2013
1 Communities
2 Members
0 Resources
14 MeSH Terms