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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 30

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Induction of HIV Neutralizing Antibody Lineages in Mice with Diverse Precursor Repertoires.
Tian M, Cheng C, Chen X, Duan H, Cheng HL, Dao M, Sheng Z, Kimble M, Wang L, Lin S, Schmidt SD, Du Z, Joyce MG, Chen Y, DeKosky BJ, Chen Y, Normandin E, Cantor E, Chen RE, Doria-Rose NA, Zhang Y, Shi W, Kong WP, Choe M, Henry AR, Laboune F, Georgiev IS, Huang PY, Jain S, McGuire AT, Georgeson E, Menis S, Douek DC, Schief WR, Stamatatos L, Kwong PD, Shapiro L, Haynes BF, Mascola JR, Alt FW
(2016) Cell 166: 1471-1484.e18
MeSH Terms: Animals, Antibodies, Monoclonal, Antibodies, Neutralizing, B-Lymphocytes, Broadly Neutralizing Antibodies, Cell Line, Disease Models, Animal, Gene Expression Regulation, HIV Antibodies, HIV-1, Immunization, Immunoglobulin Heavy Chains, Inhibitory Concentration 50, Mice, Precursor Cells, B-Lymphoid, Sequence Deletion, T-Lymphocytes
Added May 3, 2017
0 Communities
1 Members
0 Resources
17 MeSH Terms
Improving Loop Modeling of the Antibody Complementarity-Determining Region 3 Using Knowledge-Based Restraints.
Finn JA, Koehler Leman J, Willis JR, Cisneros A, Crowe JE, Meiler J
(2016) PLoS One 11: e0154811
MeSH Terms: Algorithms, Cluster Analysis, Complementarity Determining Regions, Immunoglobulin Heavy Chains, Immunoglobulin Variable Region, Models, Molecular, Protein Conformation, Structure-Activity Relationship
Added April 8, 2017
1 Communities
2 Members
0 Resources
8 MeSH Terms
Long antibody HCDR3s from HIV-naïve donors presented on a PG9 neutralizing antibody background mediate HIV neutralization.
Willis JR, Finn JA, Briney B, Sapparapu G, Singh V, King H, LaBranche CC, Montefiori DC, Meiler J, Crowe JE
(2016) Proc Natl Acad Sci U S A 113: 4446-51
MeSH Terms: Amino Acid Substitution, Antibodies, Neutralizing, Blood Donors, Complementarity Determining Regions, Female, HIV Antibodies, HIV Envelope Protein gp120, HIV-1, Humans, Immunoglobulin Heavy Chains, Male, Mutation, Missense
Added May 4, 2016
1 Communities
2 Members
0 Resources
12 MeSH Terms
Low frequency of broadly neutralizing HIV antibodies during chronic infection even in quaternary epitope targeting antibodies containing large numbers of somatic mutations.
Hicar MD, Chen X, Kalams SA, Sojar H, Landucci G, Forthal DN, Spearman P, Crowe JE
(2016) Mol Immunol 70: 94-103
MeSH Terms: Antibodies, Monoclonal, Antibodies, Neutralizing, B-Lymphocytes, Cell Separation, Enzyme-Linked Immunosorbent Assay, Epitopes, Flow Cytometry, Genes, Immunoglobulin, HIV Antibodies, HIV Infections, Humans, Immunoglobulin Heavy Chains, Immunoglobulin Variable Region, Mutation, env Gene Products, Human Immunodeficiency Virus
Added January 26, 2016
0 Communities
1 Members
0 Resources
15 MeSH Terms
Bruton's Tyrosine Kinase Synergizes with Notch2 To Govern Marginal Zone B Cells in Nonobese Diabetic Mice.
Case JB, Bonami RH, Nyhoff LE, Steinberg HE, Sullivan AM, Kendall PL
(2015) J Immunol 195: 61-70
MeSH Terms: Agammaglobulinaemia Tyrosine Kinase, Animals, Autoantibodies, Autoimmunity, B-Lymphocyte Subsets, Cell Differentiation, Cell Survival, Diabetes Mellitus, Experimental, Female, Gene Expression Regulation, Immunoglobulin Heavy Chains, Insulin, Male, Mice, Mice, Inbred C57BL, Mice, Inbred NOD, Protein-Tyrosine Kinases, Receptor, Notch2, Receptors, Antigen, B-Cell, Signal Transduction
Added December 4, 2015
2 Communities
1 Members
0 Resources
20 MeSH Terms
Influenza human monoclonal antibody 1F1 interacts with three major antigenic sites and residues mediating human receptor specificity in H1N1 viruses.
Tsibane T, Ekiert DC, Krause JC, Martinez O, Crowe JE, Wilson IA, Basler CF
(2012) PLoS Pathog 8: e1003067
MeSH Terms: Animals, Antibodies, Monoclonal, Antibodies, Viral, Antibody Affinity, Binding Sites, Antibody, Crystallography, X-Ray, Epitopes, Hemagglutinin Glycoproteins, Influenza Virus, Humans, Immunoglobulin Heavy Chains, Influenza A Virus, H1N1 Subtype, Mice, Mutagenesis, Site-Directed, Protein Structure, Quaternary
Added January 26, 2016
0 Communities
1 Members
0 Resources
14 MeSH Terms
Human peripheral blood antibodies with long HCDR3s are established primarily at original recombination using a limited subset of germline genes.
Briney BS, Willis JR, Crowe JE
(2012) PLoS One 7: e36750
MeSH Terms: Complementarity Determining Regions, Female, HIV Antibodies, HIV-1, Humans, Immunoglobulin Heavy Chains, Immunoglobulin Joining Region, Male, Recombination, Genetic, Somatic Hypermutation, Immunoglobulin
Added August 6, 2012
0 Communities
1 Members
0 Resources
10 MeSH Terms
An insertion mutation that distorts antibody binding site architecture enhances function of a human antibody.
Krause JC, Ekiert DC, Tumpey TM, Smith PB, Wilson IA, Crowe JE
(2011) mBio 2: e00345-10
MeSH Terms: Animals, Antibodies, Monoclonal, Antibodies, Viral, Base Sequence, Binding Sites, Antibody, Cell Line, Female, Humans, Immunoglobulin Heavy Chains, Immunoglobulin Variable Region, Influenza A Virus, H1N1 Subtype, Influenza, Human, Mice, Mice, Inbred BALB C, Molecular Sequence Data, Mutagenesis, Insertional, Protein Binding, Protein Conformation
Added August 6, 2012
0 Communities
1 Members
0 Resources
18 MeSH Terms
Reduced diabetes in btk-deficient nonobese diabetic mice and restoration of diabetes with provision of an anti-insulin IgH chain transgene.
Kendall PL, Moore DJ, Hulbert C, Hoek KL, Khan WN, Thomas JW
(2009) J Immunol 183: 6403-12
MeSH Terms: Agammaglobulinaemia Tyrosine Kinase, Animals, Autoantibodies, B-Lymphocyte Subsets, Diabetes Mellitus, Type 1, Immune Tolerance, Immunoglobulin Heavy Chains, Insulin, Insulin Antibodies, Mice, Mice, Inbred C57BL, Mice, Inbred NOD, Mice, Knockout, Mutation, Protein-Tyrosine Kinases, Receptors, Antigen, B-Cell, Signal Transduction, T-Lymphocyte Subsets, Transgenes
Added December 10, 2013
3 Communities
3 Members
0 Resources
19 MeSH Terms
The human neonatal B cell response to respiratory syncytial virus uses a biased antibody variable gene repertoire that lacks somatic mutations.
Williams JV, Weitkamp JH, Blum DL, LaFleur BJ, Crowe JE
(2009) Mol Immunol 47: 407-14
MeSH Terms: Adult, Antibodies, Antibody Specificity, B-Lymphocytes, Cell Separation, Child, Complementarity Determining Regions, Flow Cytometry, Humans, Immunoglobulin Heavy Chains, Immunoglobulin Light Chains, Immunoglobulin Variable Region, Infant, Infant, Newborn, Lymphocyte Count, Mutagenesis, Insertional, Mutation, Respiratory Syncytial Viruses, Species Specificity
Added February 27, 2014
0 Communities
2 Members
0 Resources
19 MeSH Terms