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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 43

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Analysis of a Therapeutic Antibody Cocktail Reveals Determinants for Cooperative and Broad Ebolavirus Neutralization.
Gilchuk P, Murin CD, Milligan JC, Cross RW, Mire CE, Ilinykh PA, Huang K, Kuzmina N, Altman PX, Hui S, Gunn BM, Bryan AL, Davidson E, Doranz BJ, Turner HL, Alkutkar T, Flinko R, Orlandi C, Carnahan R, Nargi R, Bombardi RG, Vodzak ME, Li S, Okoli A, Ibeawuchi M, Ohiaeri B, Lewis GK, Alter G, Bukreyev A, Saphire EO, Geisbert TW, Ward AB, Crowe JE
(2020) Immunity 52: 388-403.e12
MeSH Terms: Animals, Antibodies, Monoclonal, Antibodies, Neutralizing, Antibodies, Viral, Cell Line, Disease Models, Animal, Drug Therapy, Combination, Ebolavirus, Epitopes, Female, Glycoproteins, Hemorrhagic Fever, Ebola, Humans, Immunoglobulin Fab Fragments, Macaca mulatta, Male, Mice, Mice, Inbred BALB C, Molecular Mimicry, Protein Conformation
Added March 31, 2020
0 Communities
1 Members
0 Resources
20 MeSH Terms
Mechanism of differential Zika and dengue virus neutralization by a public antibody lineage targeting the DIII lateral ridge.
Zhao H, Xu L, Bombardi R, Nargi R, Deng Z, Errico JM, Nelson CA, Dowd KA, Pierson TC, Crowe JE, Diamond MS, Fremont DH
(2020) J Exp Med 217:
MeSH Terms: Aedes, Animals, Antibodies, Monoclonal, Antibodies, Neutralizing, Antibodies, Viral, Cell Line, Tumor, Chlorocebus aethiops, Cross Reactions, Crystallography, X-Ray, Dengue, Dengue Virus, Epitopes, HEK293 Cells, Humans, Hydrogen Bonding, Immunoglobulin Fab Fragments, Protein Binding, Protein Conformation, Protein Domains, Vero Cells, Viral Envelope Proteins, Zika Virus, Zika Virus Infection
Added March 31, 2020
0 Communities
1 Members
0 Resources
23 MeSH Terms
Potent anti-influenza H7 human monoclonal antibody induces separation of hemagglutinin receptor-binding head domains.
Turner HL, Pallesen J, Lang S, Bangaru S, Urata S, Li S, Cottrell CA, Bowman CA, Crowe JE, Wilson IA, Ward AB
(2019) PLoS Biol 17: e3000139
MeSH Terms: Amino Acid Sequence, Animals, Antibodies, Neutralizing, Antibody Specificity, Baculoviridae, Binding Sites, Cloning, Molecular, Cryoelectron Microscopy, Gene Expression, Hemagglutinin Glycoproteins, Influenza Virus, Hydrogen Bonding, Immunoglobulin Fab Fragments, Influenza A virus, Molecular Docking Simulation, Protein Binding, Protein Conformation, alpha-Helical, Protein Conformation, beta-Strand, Protein Interaction Domains and Motifs, Recombinant Proteins, Sequence Alignment, Sequence Homology, Amino Acid, Sf9 Cells, Spodoptera
Added March 31, 2019
0 Communities
1 Members
0 Resources
23 MeSH Terms
Mechanism of Enhanced Immature Dengue Virus Attachment to Endosomal Membrane Induced by prM Antibody.
Wirawan M, Fibriansah G, Marzinek JK, Lim XX, Ng TS, Sim AYL, Zhang Q, Kostyuchenko VA, Shi J, Smith SA, Verma CS, Anand G, Crowe JE, Bond PJ, Lok SM
(2019) Structure 27: 253-267.e8
MeSH Terms: Animals, Antibodies, Viral, Cell Line, Cryoelectron Microscopy, Dengue Virus, Endosomes, Humans, Hydrogen-Ion Concentration, Immunoglobulin Fab Fragments, Models, Molecular, THP-1 Cells, Viral Proteins, Virus Attachment
Added March 31, 2019
0 Communities
1 Members
0 Resources
13 MeSH Terms
Use of a neutralizing antibody helps identify structural features critical for binding of toxin TcdA to the host cell surface.
Kroh HK, Chandrasekaran R, Rosenthal K, Woods R, Jin X, Ohi MD, Nyborg AC, Rainey GJ, Warrener P, Spiller BW, Lacy DB
(2017) J Biol Chem 292: 14401-14412
MeSH Terms: Amino Acid Sequence, Anti-Bacterial Agents, Antibodies, Monoclonal, Humanized, Antibodies, Neutralizing, Bacterial Proteins, Bacterial Toxins, Binding Sites, Antibody, Caco-2 Cells, Clostridioides difficile, Conserved Sequence, Crystallography, X-Ray, Enterocytes, Enterotoxins, Epitope Mapping, Glucosyltransferases, Humans, Immunoglobulin Fab Fragments, Models, Molecular, Peptide Fragments, Protein Conformation, Protein Interaction Domains and Motifs, Recombinant Proteins, Repetitive Sequences, Amino Acid
Added March 15, 2018
0 Communities
3 Members
0 Resources
23 MeSH Terms
Structural Insights into Reovirus σ1 Interactions with Two Neutralizing Antibodies.
Dietrich MH, Ogden KM, Katen SP, Reiss K, Sutherland DM, Carnahan RH, Goff M, Cooper T, Dermody TS, Stehle T
(2017) J Virol 91:
MeSH Terms: Amino Acid Sequence, Animals, Antibodies, Neutralizing, Antibodies, Viral, Binding Sites, CHO Cells, Cell Line, Cricetulus, Hemagglutinin Glycoproteins, Influenza Virus, Immunoglobulin Fab Fragments, Mice, Molecular Docking Simulation, Molecular Dynamics Simulation, Neutralization Tests, Protein Binding, Protein Conformation, Protein Interaction Domains and Motifs, Reoviridae, Structure-Activity Relationship, Viral Proteins, Virus Replication
Added April 26, 2017
0 Communities
1 Members
0 Resources
21 MeSH Terms
Structural basis for norovirus neutralization by an HBGA blocking human IgA antibody.
Shanker S, Czakó R, Sapparapu G, Alvarado G, Viskovska M, Sankaran B, Atmar RL, Crowe JE, Estes MK, Prasad BV
(2016) Proc Natl Acad Sci U S A 113: E5830-E5837
MeSH Terms: Amino Acid Sequence, Antibodies, Blocking, Antigens, Blood Group Antigens, Crystallography, X-Ray, Epitopes, Genotype, Humans, Immunoglobulin A, Immunoglobulin Fab Fragments, Models, Molecular, Neutralization Tests, Norovirus, Protein Domains, Viral Proteins
Added April 13, 2017
0 Communities
1 Members
0 Resources
15 MeSH Terms
Broadly Neutralizing Alphavirus Antibodies Bind an Epitope on E2 and Inhibit Entry and Egress.
Fox JM, Long F, Edeling MA, Lin H, van Duijl-Richter MKS, Fong RH, Kahle KM, Smit JM, Jin J, Simmons G, Doranz BJ, Crowe JE, Fremont DH, Rossmann MG, Diamond MS
(2015) Cell 163: 1095-1107
MeSH Terms: Alphavirus, Alphavirus Infections, Amino Acid Sequence, Animals, Antibodies, Monoclonal, Antibodies, Neutralizing, Antibodies, Viral, Chikungunya virus, Cryoelectron Microscopy, Epitopes, Glycoproteins, Humans, Immunoglobulin Fab Fragments, Mice, Models, Molecular, Molecular Sequence Data, Protein Structure, Tertiary, Sequence Alignment, Viral Envelope Proteins, Viral Vaccines, Virus Internalization
Added January 26, 2016
0 Communities
1 Members
0 Resources
21 MeSH Terms
Structural basis for Marburg virus neutralization by a cross-reactive human antibody.
Hashiguchi T, Fusco ML, Bornholdt ZA, Lee JE, Flyak AI, Matsuoka R, Kohda D, Yanagi Y, Hammel M, Crowe JE, Saphire EO
(2015) Cell 160: 904-912
MeSH Terms: Amino Acid Sequence, Animals, Antibodies, Monoclonal, Antibodies, Neutralizing, Antibodies, Viral, Antigen-Antibody Complex, Cell Line, Cross Reactions, Crystallography, X-Ray, Drosophila, Ebolavirus, Humans, Immunoglobulin Fab Fragments, Marburg Virus Disease, Marburgvirus, Models, Molecular, Molecular Sequence Data, Mucins, Sequence Alignment, Viral Envelope Proteins
Added January 26, 2016
0 Communities
1 Members
0 Resources
20 MeSH Terms
Mechanism of human antibody-mediated neutralization of Marburg virus.
Flyak AI, Ilinykh PA, Murin CD, Garron T, Shen X, Fusco ML, Hashiguchi T, Bornholdt ZA, Slaughter JC, Sapparapu G, Klages C, Ksiazek TG, Ward AB, Saphire EO, Bukreyev A, Crowe JE
(2015) Cell 160: 893-903
MeSH Terms: Adult, Animals, Antibodies, Monoclonal, Antibodies, Neutralizing, Antibodies, Viral, Antigen-Antibody Complex, B-Lymphocytes, Female, Humans, Immunoglobulin Fab Fragments, Marburg Virus Disease, Marburgvirus, Models, Molecular, Mutation, Protein Structure, Tertiary, Viral Envelope Proteins
Added January 26, 2016
0 Communities
1 Members
0 Resources
16 MeSH Terms