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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 181

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TBCRC 032 IB/II Multicenter Study: Molecular Insights to AR Antagonist and PI3K Inhibitor Efficacy in Patients with AR Metastatic Triple-Negative Breast Cancer.
Lehmann BD, Abramson VG, Sanders ME, Mayer EL, Haddad TC, Nanda R, Van Poznak C, Storniolo AM, Nangia JR, Gonzalez-Ericsson PI, Sanchez V, Johnson KN, Abramson RG, Chen SC, Shyr Y, Arteaga CL, Wolff AC, Pietenpol JA, Translational Breast Cancer Research Consortium
(2020) Clin Cancer Res 26: 2111-2123
MeSH Terms: Androgen Receptor Antagonists, Antineoplastic Combined Chemotherapy Protocols, Benzamides, Class I Phosphatidylinositol 3-Kinases, Female, Humans, Imidazoles, Middle Aged, Neoplasm Metastasis, Nitriles, Oxazepines, Phenylthiohydantoin, Protein Kinase Inhibitors, Receptors, Androgen, Survival Rate, Triple Negative Breast Neoplasms
Added March 30, 2020
0 Communities
1 Members
0 Resources
16 MeSH Terms
Novel three-dimensional cultures provide insights into thyroid cancer behavior.
Lee MA, Bergdorf KN, Phifer CJ, Jones CY, Byon SY, Sawyer LM, Bauer JA, Weiss VL
(2020) Endocr Relat Cancer 27: 111-121
MeSH Terms: Actin Cytoskeleton, Antineoplastic Agents, Apoptosis, Cell Culture Techniques, Cell Movement, Cell Proliferation, High-Throughput Screening Assays, Humans, Imidazoles, Oximes, Spheroids, Cellular, Thyroid Neoplasms, Tumor Cells, Cultured
Added March 3, 2020
0 Communities
2 Members
0 Resources
13 MeSH Terms
Discovery of a novel 2,3-dimethylimidazo[1,2-a]pyrazine-6-carboxamide M positive allosteric modulator (PAM) chemotype.
Temple KJ, Engers JL, Long MF, Watson KJ, Chang S, Luscombe VB, Jenkins MT, Rodriguez AL, Niswender CM, Bridges TM, Conn PJ, Engers DW, Lindsley CW
(2020) Bioorg Med Chem Lett 30: 126812
MeSH Terms: Allosteric Regulation, Drug Design, Drug Evaluation, Preclinical, Humans, Imidazoles, Kinetics, Protein Binding, Pyrazines, Receptor, Muscarinic M4, Structure-Activity Relationship
Added March 3, 2020
0 Communities
1 Members
0 Resources
10 MeSH Terms
Thrombotic microangiopathy as a cause of cardiovascular toxicity from the BCR-ABL1 tyrosine kinase inhibitor ponatinib.
Latifi Y, Moccetti F, Wu M, Xie A, Packwood W, Qi Y, Ozawa K, Shentu W, Brown E, Shirai T, McCarty OJ, Ruggeri Z, Moslehi J, Chen J, Druker BJ, López JA, Lindner JR
(2019) Blood 133: 1597-1606
MeSH Terms: Animals, Aorta, Cardiovascular Diseases, Endothelium, Fusion Proteins, bcr-abl, Humans, Imidazoles, Ischemia, Mice, Mice, Knockout, Platelet Adhesiveness, Protein Kinase Inhibitors, Pyridazines, Thrombotic Microangiopathies, Ventricular Dysfunction, von Willebrand Factor
Added February 24, 2019
0 Communities
1 Members
0 Resources
16 MeSH Terms
Successful Aspects of the Coadministration of Sterol 14α-Demethylase Inhibitor VFV and Benznidazole in Experimental Mouse Models of Chagas Disease Caused by the Drug-Resistant Strain of Trypanosoma cruzi.
Guedes-da-Silva FH, Batista DDGJ, Da Silva CF, Pavão BP, Batista MM, Moreira OC, Souza LRQ, Britto C, Rachakonda G, Villalta F, Lepesheva GI, Soeiro MNC
(2019) ACS Infect Dis 5: 365-371
MeSH Terms: 14-alpha Demethylase Inhibitors, Animals, Chagas Disease, Disease Models, Animal, Drug Synergism, Drug Therapy, Combination, Humans, Male, Mice, Nitroimidazoles, Protozoan Proteins, Sterol 14-Demethylase, Trypanocidal Agents, Trypanosoma cruzi
Added July 2, 2021
0 Communities
1 Members
0 Resources
MeSH Terms
Computational Immune Monitoring Reveals Abnormal Double-Negative T Cells Present across Human Tumor Types.
Greenplate AR, McClanahan DD, Oberholtzer BK, Doxie DB, Roe CE, Diggins KE, Leelatian N, Rasmussen ML, Kelley MC, Gama V, Siska PJ, Rathmell JC, Ferrell PB, Johnson DB, Irish JM
(2019) Cancer Immunol Res 7: 86-99
MeSH Terms: Adenoids, Adult, Aged, Antibodies, Monoclonal, Humanized, Antineoplastic Agents, Immunological, Female, Humans, Imidazoles, MAP Kinase Kinase Kinases, Male, Middle Aged, Monitoring, Immunologic, Neoplasms, Oximes, Palatine Tonsil, Proto-Oncogene Proteins B-raf, Pyridones, Pyrimidinones, T-Lymphocytes
Added November 11, 2018
3 Communities
2 Members
0 Resources
19 MeSH Terms
MEK Inhibitor Reverses Metaplasia and Allows Re-Emergence of Normal Lineages in Helicobacter pylori-Infected Gerbils.
Yang Q, Yasuda T, Choi E, Toyoda T, Roland JT, Uchida E, Yoshida H, Seto Y, Goldenring JR, Nomura S
(2019) Gastroenterology 156: 577-581.e4
MeSH Terms: Acrylonitrile, Aniline Compounds, Animals, Benzimidazoles, Biopsy, Needle, Disease Models, Animal, Gastric Mucosa, Gerbillinae, Helicobacter Infections, Helicobacter pylori, Immunohistochemistry, Male, Metaplasia, Random Allocation, Reference Values, Treatment Outcome
Added November 14, 2018
0 Communities
1 Members
0 Resources
16 MeSH Terms
Discovery of Tricyclic Triazolo- and Imidazopyridine Lactams as M Positive Allosteric Modulators.
Engers JL, Bender AM, Kalbfleisch JJ, Cho HP, Lingenfelter KS, Luscombe VB, Han C, Melancon BJ, Blobaum AL, Dickerson JW, Rook JM, Niswender CM, Emmitte KA, Conn PJ, Lindsley CW
(2019) ACS Chem Neurosci 10: 1035-1042
MeSH Terms: Allosteric Regulation, Animals, Drug Discovery, Humans, Imidazoles, Lactams, Mice, Muscarinic Agonists, Pyridines, Rats, Receptor, Muscarinic M1
Added March 3, 2020
0 Communities
2 Members
0 Resources
11 MeSH Terms
Sterol 14α-Demethylase Structure-Based Design of VNI (( R)- N-(1-(2,4-Dichlorophenyl)-2-(1 H-imidazol-1-yl)ethyl)-4-(5-phenyl-1,3,4-oxadiazol-2-yl)benzamide)) Derivatives To Target Fungal Infections: Synthesis, Biological Evaluation, and Crystallographic Analysis.
Friggeri L, Hargrove TY, Wawrzak Z, Blobaum AL, Rachakonda G, Lindsley CW, Villalta F, Nes WD, Botta M, Guengerich FP, Lepesheva GI
(2018) J Med Chem 61: 5679-5691
MeSH Terms: 14-alpha Demethylase Inhibitors, Antifungal Agents, Aspergillus fumigatus, Candida albicans, Catalytic Domain, Chemistry Techniques, Synthetic, Crystallography, X-Ray, Drug Design, Imidazoles, Ligands, Models, Molecular, Sterol 14-Demethylase
Added July 2, 2021
0 Communities
1 Members
0 Resources
MeSH Terms
BRAF and MEK inhibitor therapy eliminates Nestin-expressing melanoma cells in human tumors.
Doxie DB, Greenplate AR, Gandelman JS, Diggins KE, Roe CE, Dahlman KB, Sosman JA, Kelley MC, Irish JM
(2018) Pigment Cell Melanoma Res 31: 708-719
MeSH Terms: Antibodies, Neoplasm, Cell Line, Tumor, Humans, Imidazoles, Melanoma, Mitogen-Activated Protein Kinase Kinases, Nestin, Oximes, Phenotype, Protein Kinase Inhibitors, Proto-Oncogene Proteins B-raf, Pyridones, Pyrimidinones
Added May 21, 2018
2 Communities
1 Members
0 Resources
13 MeSH Terms