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Results: 1 to 10 of 17

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Modified sites and functional consequences of 4-oxo-2-nonenal adducts in HDL that are elevated in familial hypercholesterolemia.
May-Zhang LS, Yermalitsky V, Melchior JT, Morris J, Tallman KA, Borja MS, Pleasent T, Amarnath V, Song W, Yancey PG, Davidson WS, Linton MF, Davies SS
(2019) J Biol Chem 294: 19022-19033
MeSH Terms: Aldehydes, Animals, Apolipoprotein A-I, Atherosclerosis, Cells, Cultured, Female, Humans, Hyperlipoproteinemia Type II, Lipoproteins, HDL, Lysine, Male, Mice, Mice, Inbred C57BL, Mice, Knockout
Added November 13, 2019
0 Communities
1 Members
0 Resources
14 MeSH Terms
Clinical Genetic Testing for Familial Hypercholesterolemia: JACC Scientific Expert Panel.
Sturm AC, Knowles JW, Gidding SS, Ahmad ZS, Ahmed CD, Ballantyne CM, Baum SJ, Bourbon M, Carrié A, Cuchel M, de Ferranti SD, Defesche JC, Freiberger T, Hershberger RE, Hovingh GK, Karayan L, Kastelein JJP, Kindt I, Lane SR, Leigh SE, Linton MF, Mata P, Neal WA, Nordestgaard BG, Santos RD, Harada-Shiba M, Sijbrands EJ, Stitziel NO, Yamashita S, Wilemon KA, Ledbetter DH, Rader DJ, Convened by the Familial Hypercholesterolemia Foundation
(2018) J Am Coll Cardiol 72: 662-680
MeSH Terms: Apolipoproteins B, Expert Testimony, Genetic Counseling, Genetic Testing, Humans, Hyperlipoproteinemia Type II, Proprotein Convertase 9, Receptors, LDL
Added April 10, 2019
0 Communities
1 Members
0 Resources
8 MeSH Terms
Modification by isolevuglandins, highly reactive γ-ketoaldehydes, deleteriously alters high-density lipoprotein structure and function.
May-Zhang LS, Yermalitsky V, Huang J, Pleasent T, Borja MS, Oda MN, Jerome WG, Yancey PG, Linton MF, Davies SS
(2018) J Biol Chem 293: 9176-9187
MeSH Terms: Aldehydes, Animals, Apolipoprotein A-I, Apolipoprotein A-II, Cells, Cultured, Cholesterol, Female, Humans, Hyperlipoproteinemia Type II, Ketones, Lipid Metabolism, Lipids, Lipoproteins, HDL, Macrophages, Male, Mice, Mice, Inbred C57BL, Phosphatidylethanolamines
Added August 3, 2018
1 Communities
4 Members
0 Resources
18 MeSH Terms
Health disparities among adult patients with a phenotypic diagnosis of familial hypercholesterolemia in the CASCADE-FH™ patient registry.
Amrock SM, Duell PB, Knickelbine T, Martin SS, O'Brien EC, Watson KE, Mitri J, Kindt I, Shrader P, Baum SJ, Hemphill LC, Ahmed CD, Andersen RL, Kullo IJ, McCann D, Larry JA, Murray MF, Fishberg R, Guyton JR, Wilemon K, Roe MT, Rader DJ, Ballantyne CM, Underberg JA, Thompson P, Duffy D, Linton MF, Shapiro MD, Moriarty PM, Knowles JW, Ahmad ZS
(2017) Atherosclerosis 267: 19-26
MeSH Terms: Adult, African Americans, Aged, Asian Americans, Cardiovascular Diseases, Cholesterol, HDL, Cholesterol, LDL, Ethnicity, Female, Health Status Disparities, Healthcare Disparities, Humans, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Hyperlipoproteinemia Type II, Male, Middle Aged, Multicenter Studies as Topic, Odds Ratio, Phenotype, Prospective Studies, Registries, Retrospective Studies, Risk Factors, Sex Factors
Added April 10, 2018
0 Communities
1 Members
0 Resources
24 MeSH Terms
US physician practices for diagnosing familial hypercholesterolemia: data from the CASCADE-FH registry.
Ahmad ZS, Andersen RL, Andersen LH, O'Brien EC, Kindt I, Shrader P, Vasandani C, Newman CB, deGoma EM, Baum SJ, Hemphill LC, Hudgins LC, Ahmed CD, Kullo IJ, Gidding SS, Duffy D, Neal W, Wilemon K, Roe MT, Rader DJ, Ballantyne CM, Linton MF, Duell PB, Shapiro MD, Moriarty PM, Knowles JW
(2016) J Clin Lipidol 10: 1223-9
MeSH Terms: Adult, Cholesterol, LDL, Cross-Sectional Studies, Databases, Factual, Female, Humans, Hyperlipoproteinemia Type II, Male, Middle Aged, Physicians, Registries, United States
Added April 10, 2018
0 Communities
1 Members
0 Resources
MeSH Terms
Treatment Gaps in Adults With Heterozygous Familial Hypercholesterolemia in the United States: Data From the CASCADE-FH Registry.
deGoma EM, Ahmad ZS, O'Brien EC, Kindt I, Shrader P, Newman CB, Pokharel Y, Baum SJ, Hemphill LC, Hudgins LC, Ahmed CD, Gidding SS, Duffy D, Neal W, Wilemon K, Roe MT, Rader DJ, Ballantyne CM, Linton MF, Duell PB, Shapiro MD, Moriarty PM, Knowles JW
(2016) Circ Cardiovasc Genet 9: 240-9
MeSH Terms: Adult, Aged, Biomarkers, Chi-Square Distribution, Cholesterol, LDL, Comorbidity, Coronary Disease, Cross-Sectional Studies, Diabetes Mellitus, Down-Regulation, Early Diagnosis, Female, Genetic Predisposition to Disease, Guideline Adherence, Heterozygote, Humans, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Hyperlipoproteinemia Type II, Hypertension, Logistic Models, Male, Middle Aged, Multivariate Analysis, Odds Ratio, Phenotype, Practice Guidelines as Topic, Practice Patterns, Physicians', Predictive Value of Tests, Prevalence, Professional Practice Gaps, Registries, Risk Factors, Time Factors, Treatment Outcome, United States
Added April 10, 2018
0 Communities
1 Members
0 Resources
MeSH Terms
Response to Duell et al.
Tavori H, Giunzioni I, Linton MF, Fazio S
(2014) Circ Res 115: e5
MeSH Terms: Blood Component Removal, Humans, Hyperlipoproteinemia Type II, Lipoproteins, LDL, Proprotein Convertases, Serine Endopeptidases
Added February 12, 2015
0 Communities
1 Members
0 Resources
6 MeSH Terms
Loss of plasma proprotein convertase subtilisin/kexin 9 (PCSK9) after lipoprotein apheresis.
Tavori H, Giunzioni I, Linton MF, Fazio S
(2013) Circ Res 113: 1290-5
MeSH Terms: Apoptosis, Blood Component Removal, HEK293 Cells, Humans, Hyperlipoproteinemia Type II, Lipoproteins, LDL, Proprotein Convertase 9, Proprotein Convertases, Serine Endopeptidases
Added May 27, 2014
1 Communities
1 Members
0 Resources
9 MeSH Terms
Bone morphogenic protein-4 induces hypertension in mice: role of noggin, vascular NADPH oxidases, and impaired vasorelaxation.
Miriyala S, Gongora Nieto MC, Mingone C, Smith D, Dikalov S, Harrison DG, Jo H
(2006) Circulation 113: 2818-25
MeSH Terms: Acetophenones, Acetylcholine, Animals, Aorta, Thoracic, Apolipoproteins E, Bone Morphogenetic Protein 4, Bone Morphogenetic Proteins, Calcimycin, Carrier Proteins, Diet, Atherogenic, Endothelium, Vascular, Enzyme Activation, Humans, Hyperlipoproteinemia Type II, Hypertension, Male, Mice, Mice, Inbred C57BL, Mice, Knockout, NADPH Oxidases, Nitroglycerin, Recombinant Fusion Proteins, Superoxides, Vasodilator Agents
Added February 17, 2016
0 Communities
1 Members
0 Resources
24 MeSH Terms
Retardation of atherosclerosis by overexpression of catalase or both Cu/Zn-superoxide dismutase and catalase in mice lacking apolipoprotein E.
Yang H, Roberts LJ, Shi MJ, Zhou LC, Ballard BR, Richardson A, Guo ZM
(2004) Circ Res 95: 1075-81
MeSH Terms: Animals, Aorta, Aortic Diseases, Apolipoproteins E, Arteriosclerosis, Catalase, Cholesterol, Enzyme Induction, F2-Isoprostanes, Foam Cells, Humans, Hydrogen Peroxide, Hyperlipoproteinemia Type II, Lipid Peroxidation, Lipids, Male, Mice, Mice, Inbred C57BL, Mice, Knockout, Mice, Transgenic, Oxidative Stress, Recombinant Fusion Proteins, Superoxide Dismutase, Triglycerides
Added December 10, 2013
0 Communities
1 Members
0 Resources
24 MeSH Terms