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Using Human 'Experiments of Nature' to Predict Drug Safety Issues: An Example with PCSK9 Inhibitors.
Jerome RN, Pulley JM, Roden DM, Shirey-Rice JK, Bastarache LA, R Bernard G, B Ekstrom L, Lancaster WJ, Denny JC
(2018) Drug Saf 41: 303-311
MeSH Terms: Cholesterol, LDL, Enzyme Inhibitors, Female, Genotype, Humans, Hypercholesterolemia, Male, PCSK9 Inhibitors, Phenotype, Polymorphism, Single Nucleotide, Product Surveillance, Postmarketing, Risk Factors, Spinal Dysraphism
Added March 14, 2018
0 Communities
2 Members
0 Resources
13 MeSH Terms
Jnk1 Deficiency in Hematopoietic Cells Suppresses Macrophage Apoptosis and Increases Atherosclerosis in Low-Density Lipoprotein Receptor Null Mice.
Babaev VR, Yeung M, Erbay E, Ding L, Zhang Y, May JM, Fazio S, Hotamisligil GS, Linton MF
(2016) Arterioscler Thromb Vasc Biol 36: 1122-31
MeSH Terms: Animals, Aorta, Aortic Diseases, Apoptosis, Atherosclerosis, Bone Marrow Cells, Bone Marrow Transplantation, Cell Survival, Cells, Cultured, Diet, High-Fat, Disease Models, Animal, Endoplasmic Reticulum Stress, Genetic Predisposition to Disease, Hypercholesterolemia, Macrophages, Mice, Inbred C57BL, Mice, Knockout, Mitogen-Activated Protein Kinase 8, Mitogen-Activated Protein Kinase 9, PTEN Phosphohydrolase, Phenotype, Plaque, Atherosclerotic, Protein Kinase Inhibitors, Proto-Oncogene Proteins c-akt, Receptors, LDL, Signal Transduction, bcl-Associated Death Protein
Added April 10, 2018
0 Communities
1 Members
0 Resources
MeSH Terms
Cardiology Patient Page. ABCDE Steps for Heart and Vascular Wellness Following a Prostate Cancer Diagnosis.
Guan J, Khambhati J, Jones LW, Morgans A, Allaf M, Penson DF, Moslehi J
(2015) Circulation 132: e218-20
MeSH Terms: Adenocarcinoma, Androgen Antagonists, Androgens, Antineoplastic Agents, Hormonal, Cardiovascular Diseases, Comorbidity, Diabetes Mellitus, Diet, Disease Susceptibility, Exercise, Health Promotion, Humans, Hypercholesterolemia, Hypertension, Life Style, Male, Neoplasms, Hormone-Dependent, Prostatic Neoplasms, Risk Factors, Smoking Cessation, Survivors
Added February 4, 2016
0 Communities
2 Members
0 Resources
21 MeSH Terms
Macrophage apoAI protects against dyslipidemia-induced dermatitis and atherosclerosis without affecting HDL.
Tavori H, Su YR, Yancey PG, Giunzioni I, Wilhelm AJ, Blakemore JL, Zabalawi M, Linton MF, Sorci-Thomas MG, Fazio S
(2015) J Lipid Res 56: 635-643
MeSH Terms: Animals, Apolipoprotein A-I, Atherosclerosis, B-Lymphocytes, CD4-Positive T-Lymphocytes, Dendritic Cells, Dermatitis, Gene Expression Regulation, Humans, Hypercholesterolemia, Lipoproteins, HDL, Macrophages, Mice, Mice, Knockout
Added January 20, 2015
0 Communities
3 Members
0 Resources
14 MeSH Terms
From ST segments to endothelial pathophysiology: hypercholesterolemia and endothelial superoxide production.
Harrison DG
(2014) J Clin Invest 124: 473-5
MeSH Terms: Animals, Biomedical Research, Clinical Trials as Topic, Coronary Vasospasm, Endothelium, Vascular, History, 20th Century, History, 21st Century, Humans, Hypercholesterolemia, Inflammation, Oxidative Stress, Reactive Oxygen Species, Superoxides, Vascular Diseases
Added March 31, 2015
1 Communities
1 Members
0 Resources
14 MeSH Terms
Impaired liver regeneration in Ldlr-/- mice is associated with an altered hepatic profile of cytokines, growth factors, and lipids.
Pauta M, Rotllan N, Vales F, Fernandez-Hernando A, Allen RM, Ford DA, Marí M, Jiménez W, Baldán A, Morales-Ruiz M, Fernández-Hernando C
(2013) J Hepatol 59: 731-7
MeSH Terms: Animals, Cell Cycle Checkpoints, Cholesterol, Fatty Liver, Hepatectomy, Hepatocyte Growth Factor, Hypercholesterolemia, Interleukin-6, Lipid Metabolism, Liver, Liver Regeneration, Male, Mice, Mice, Inbred C57BL, Mice, Knockout, Receptors, LDL, Signal Transduction, Tumor Necrosis Factor-alpha
Added February 12, 2016
0 Communities
1 Members
0 Resources
18 MeSH Terms
Serum proprotein convertase subtilisin/kexin type 9 and cell surface low-density lipoprotein receptor: evidence for a reciprocal regulation.
Tavori H, Fan D, Blakemore JL, Yancey PG, Ding L, Linton MF, Fazio S
(2013) Circulation 127: 2403-13
MeSH Terms: Animals, Cells, Cultured, Cholesterol, Disease Models, Animal, Humans, Hypercholesterolemia, In Vitro Techniques, Male, Mice, Mice, Inbred C57BL, Mice, Knockout, Mice, Transgenic, Proprotein Convertase 9, Proprotein Convertases, Receptors, LDL, Serine Endopeptidases, Transfection
Added December 10, 2013
0 Communities
1 Members
0 Resources
17 MeSH Terms
Nuclear transport modulation reduces hypercholesterolemia, atherosclerosis, and fatty liver.
Liu Y, Major AS, Zienkiewicz J, Gabriel CL, Veach RA, Moore DJ, Collins RD, Hawiger J
(2013) J Am Heart Assoc 2: e000093
MeSH Terms: Active Transport, Cell Nucleus, Animals, Atherosclerosis, Cell Nucleus, Cell-Penetrating Peptides, Cholesterol, Dietary Fats, Disease Models, Animal, Fatty Liver, Female, Hypercholesterolemia, Liver, Mice, Mice, Transgenic, NF-kappa B, Peptides, Sterol Regulatory Element Binding Proteins, Transcription Factors, Triglycerides
Added February 11, 2014
1 Communities
4 Members
0 Resources
19 MeSH Terms
Nicotinic acetylcholine receptor α1 promotes calpain-1 activation and macrophage inflammation in hypercholesterolemic nephropathy.
Zhang G, Thomas AL, Marshall AL, Kernan KA, Su Y, Zheng Y, Takano J, Saido TC, Eddy AA
(2011) Lab Invest 91: 106-23
MeSH Terms: Actins, Animals, Antigens, Differentiation, Apolipoproteins E, Blotting, Northern, Blotting, Western, Calcium-Binding Proteins, Calpain, Cell Line, Female, Hypercholesterolemia, Inflammation, Kidney, Kidney Diseases, Macrophages, Male, Mice, Mice, 129 Strain, Mice, Inbred C57BL, Mice, Knockout, Monocytes, Nephrectomy, RNA Interference, Receptors, Nicotinic, Transforming Growth Factor beta1
Added February 3, 2012
0 Communities
1 Members
0 Resources
25 MeSH Terms
Statins for acutely hospitalized patients: randomized controlled trials are long overdue.
Bernard GR
(2010) Crit Care 14: 141
MeSH Terms: Critical Illness, Humans, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Hypercholesterolemia, Inpatients, Randomized Controlled Trials as Topic, Survival Analysis
Added March 5, 2014
0 Communities
1 Members
0 Resources
7 MeSH Terms