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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 75

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Inhibition of hypoxia-inducible factor-prolyl hydroxylation protects from cyclophosphamide-induced bladder injury and urinary dysfunction.
Clayton DB, Tong CMC, Li B, Taylor AS, De S, Mason MD, Dudley AG, Davidoff O, Kobayashi H, Haase VH
(2022) Am J Physiol Renal Physiol 323: F81-F91
MeSH Terms: Animals, Cyclophosphamide, Disease Models, Animal, Hydroxylation, Hypoxia, Hypoxia-Inducible Factor 1, alpha Subunit, Hypoxia-Inducible Factor-Proline Dioxygenases, Inflammation, Mice, Procollagen-Proline Dioxygenase, Prolyl Hydroxylases, Urinary Bladder
Added May 3, 2022
0 Communities
1 Members
0 Resources
12 MeSH Terms
In Vitro Activation of Cytochrome P450 46A1 (CYP46A1) by Efavirenz-Related Compounds.
Mast N, Verwilst P, Wilkey CJ, Guengerich FP, Pikuleva IA
(2020) J Med Chem 63: 6477-6488
MeSH Terms: Alkynes, Allosteric Site, Benzoxazines, Catalytic Domain, Cholesterol, Cholesterol 24-Hydroxylase, Cyclopropanes, Cytochrome P-450 CYP3A Inducers, Humans, Hydroxylation, In Vitro Techniques, Pharmaceutical Preparations, Protein Conformation
Added March 3, 2020
0 Communities
1 Members
0 Resources
13 MeSH Terms
A Role for the Orphan Human Cytochrome P450 2S1 in Polyunsaturated Fatty Acid -1 Hydroxylation Using an Untargeted Metabolomic Approach.
Fekry MI, Xiao Y, Berg JZ, Guengerich FP
(2019) Drug Metab Dispos 47: 1325-1332
MeSH Terms: Animals, Cytochrome P-450 CYP4A, Cytochrome P-450 Enzyme System, Fatty Acids, Unsaturated, Female, Gastrointestinal Tract, Humans, Hydroxylation, Isotope Labeling, Metabolomics, Rats
Added March 3, 2020
0 Communities
1 Members
0 Resources
11 MeSH Terms
VHL substrate transcription factor ZHX2 as an oncogenic driver in clear cell renal cell carcinoma.
Zhang J, Wu T, Simon J, Takada M, Saito R, Fan C, Liu XD, Jonasch E, Xie L, Chen X, Yao X, Teh BT, Tan P, Zheng X, Li M, Lawrence C, Fan J, Geng J, Liu X, Hu L, Wang J, Liao C, Hong K, Zurlo G, Parker JS, Auman JT, Perou CM, Rathmell WK, Kim WY, Kirschner MW, Kaelin WG, Baldwin AS, Zhang Q
(2018) Science 361: 290-295
MeSH Terms: Animals, Carcinoma, Renal Cell, Chromatin Immunoprecipitation, Female, Gene Expression Regulation, Neoplastic, Homeodomain Proteins, Humans, Hydroxylation, Kidney Neoplasms, Mice, Mice, SCID, Molecular Targeted Therapy, Mutation, NF-kappa B, Oncogenes, Substrate Specificity, Transcription Factors, Von Hippel-Lindau Tumor Suppressor Protein
Added October 30, 2019
0 Communities
1 Members
0 Resources
MeSH Terms
Hypoxia-inducible factor prolyl-4-hydroxylation in FOXD1 lineage cells is essential for normal kidney development.
Kobayashi H, Liu J, Urrutia AA, Burmakin M, Ishii K, Rajan M, Davidoff O, Saifudeen Z, Haase VH
(2017) Kidney Int 92: 1370-1383
MeSH Terms: Anemia, Animals, Basic Helix-Loop-Helix Transcription Factors, Cell Hypoxia, Clinical Trials, Phase III as Topic, Disease Models, Animal, Enzyme Inhibitors, Forkhead Transcription Factors, Humans, Hydroxylation, Hypoxia-Inducible Factor-Proline Dioxygenases, Kidney, Kidney Diseases, Mice, Molecular Targeted Therapy, Mutation, Organ Size, Procollagen-Proline Dioxygenase, Renal Insufficiency, Stromal Cells
Added November 21, 2017
0 Communities
1 Members
0 Resources
20 MeSH Terms
Human mitochondrial cytochrome P450 27C1 is localized in skin and preferentially desaturates -retinol to 3,4-dehydroretinol.
Johnson KM, Phan TTN, Albertolle ME, Guengerich FP
(2017) J Biol Chem 292: 13672-13687
MeSH Terms: Biocatalysis, Cytochrome P450 Family 27, Diterpenes, Gene Expression Profiling, Gene Expression Regulation, Enzymologic, Humans, Hydrogenation, Hydroxylation, Isoenzymes, Kinetics, Mitochondria, Molecular Structure, Organ Specificity, Oxidation-Reduction, Peptide Fragments, Proteolysis, Proteomics, Skin, Stereoisomerism, Substrate Specificity, Vitamin A
Added March 14, 2018
0 Communities
1 Members
0 Resources
21 MeSH Terms
Mechanism of 17╬▒,20-Lyase and New Hydroxylation Reactions of Human Cytochrome P450 17A1: 18O LABELING AND OXYGEN SURROGATE EVIDENCE FOR A ROLE OF A PERFERRYL OXYGEN.
Yoshimoto FK, Gonzalez E, Auchus RJ, Guengerich FP
(2016) J Biol Chem 291: 17143-64
MeSH Terms: Humans, Hydroxylation, Isotope Labeling, Oxygen, Progesterone, Steroid 17-alpha-Hydroxylase
Added March 14, 2018
0 Communities
1 Members
0 Resources
6 MeSH Terms
Comprehensive Characterization of Glycosylation and Hydroxylation of Basement Membrane Collagen IV by High-Resolution Mass Spectrometry.
Basak T, Vega-Montoto L, Zimmerman LJ, Tabb DL, Hudson BG, Vanacore RM
(2016) J Proteome Res 15: 245-58
MeSH Terms: Amino Acid Sequence, Animals, Basement Membrane, Cell Line, Chromatography, Reverse-Phase, Collagen Type IV, Glycosylation, Humans, Hydroxylation, Lens Capsule, Crystalline, Mice, Molecular Sequence Data, Protein Processing, Post-Translational, Tandem Mass Spectrometry
Added December 3, 2015
1 Communities
3 Members
1 Resources
14 MeSH Terms
Simulation of Human Plasma Concentrations of Thalidomide and Primary 5-Hydroxylated Metabolites Explored with Pharmacokinetic Data in Humanized TK-NOG Mice.
Nishiyama S, Suemizu H, Shibata N, Guengerich FP, Yamazaki H
(2015) Chem Res Toxicol 28: 2088-90
MeSH Terms: Animals, Cytochrome P-450 CYP3A, Glutathione, Hepatocytes, Humans, Hydroxylation, Liver, Mice, Teratogens, Thalidomide
Added March 14, 2018
0 Communities
1 Members
0 Resources
10 MeSH Terms
Human Cytochrome P450 21A2, the Major Steroid 21-Hydroxylase: STRUCTURE OF THE ENZYME┬ĚPROGESTERONE SUBSTRATE COMPLEX AND RATE-LIMITING C-H BOND CLEAVAGE.
Pallan PS, Wang C, Lei L, Yoshimoto FK, Auchus RJ, Waterman MR, Guengerich FP, Egli M
(2015) J Biol Chem 290: 13128-43
MeSH Terms: Amino Acid Sequence, Animals, Binding Sites, Catalysis, Catalytic Domain, Cattle, Crystallography, X-Ray, Deuterium, Humans, Hydroxylation, Kinetics, Molecular Sequence Data, Oxidation-Reduction, Progesterone, Protein Binding, Protein Conformation, Sequence Homology, Amino Acid, Steroid 21-Hydroxylase, Substrate Specificity
Added March 14, 2018
0 Communities
1 Members
0 Resources
19 MeSH Terms