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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 31

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Panobinostat sensitizes cyclin E high, homologous recombination-proficient ovarian cancer to olaparib.
Wilson AJ, Sarfo-Kantanka K, Barrack T, Steck A, Saskowski J, Crispens MA, Khabele D
(2016) Gynecol Oncol 143: 143-151
MeSH Terms: Antineoplastic Agents, Cyclin E, DNA Repair, Drug Synergism, Female, Homologous Recombination, Humans, Hydroxamic Acids, Indoles, Oncogene Proteins, Ovarian Neoplasms, Panobinostat, Phthalazines, Piperazines
Added March 4, 2019
0 Communities
2 Members
0 Resources
MeSH Terms
A Phase I Study of CUDC-101, a Multitarget Inhibitor of HDACs, EGFR, and HER2, in Combination with Chemoradiation in Patients with Head and Neck Squamous Cell Carcinoma.
Galloway TJ, Wirth LJ, Colevas AD, Gilbert J, Bauman JE, Saba NF, Raben D, Mehra R, Ma AW, Atoyan R, Wang J, Burtness B, Jimeno A
(2015) Clin Cancer Res 21: 1566-73
MeSH Terms: Aged, Antineoplastic Agents, Carcinoma, Squamous Cell, Chemoradiotherapy, Cisplatin, ErbB Receptors, Female, Head and Neck Neoplasms, Histone Deacetylases, Humans, Hydroxamic Acids, Male, Maximum Tolerated Dose, Middle Aged, Quinazolines, Radiotherapy, Receptor, ErbB-2, Squamous Cell Carcinoma of Head and Neck
Added February 17, 2015
0 Communities
1 Members
0 Resources
18 MeSH Terms
Histone deacetylase inhibitor treatment induces 'BRCAness' and synergistic lethality with PARP inhibitor and cisplatin against human triple negative breast cancer cells.
Ha K, Fiskus W, Choi DS, Bhaskara S, Cerchietti L, Devaraj SG, Shah B, Sharma S, Chang JC, Melnick AM, Hiebert S, Bhalla KN
(2014) Oncotarget 5: 5637-50
MeSH Terms: Animals, Antineoplastic Combined Chemotherapy Protocols, Apoptosis, Ataxia Telangiectasia Mutated Proteins, BRCA1 Protein, Cell Line, Tumor, Checkpoint Kinase 1, Cisplatin, DNA Damage, Drug Synergism, Enzyme Inhibitors, Female, Gene Knockdown Techniques, HSP90 Heat-Shock Proteins, HeLa Cells, Histone Deacetylase Inhibitors, Humans, Hydroxamic Acids, Indoles, MCF-7 Cells, Mice, Panobinostat, Poly(ADP-ribose) Polymerase Inhibitors, Protein Kinases, Reactive Oxygen Species, Triple Negative Breast Neoplasms, Vorinostat, Xenograft Model Antitumor Assays
Added September 28, 2015
0 Communities
1 Members
0 Resources
28 MeSH Terms
Suberoylanilide hydroxamic acid (SAHA) enhances olaparib activity by targeting homologous recombination DNA repair in ovarian cancer.
Konstantinopoulos PA, Wilson AJ, Saskowski J, Wass E, Khabele D
(2014) Gynecol Oncol 133: 599-606
MeSH Terms: Animals, Antineoplastic Agents, Carcinoma, Ovarian Epithelial, Cell Line, Tumor, Cell Proliferation, Cell Survival, DNA Damage, DNA, Neoplasm, Down-Regulation, Drug Resistance, Neoplasm, Drug Synergism, Female, Histone Deacetylase Inhibitors, Humans, Hydroxamic Acids, Mice, Mice, Nude, Neoplasms, Glandular and Epithelial, Ovarian Neoplasms, Phthalazines, Piperazines, Recombinational DNA Repair, Tissue Array Analysis, Vorinostat, Xenograft Model Antitumor Assays
Added March 28, 2014
0 Communities
3 Members
0 Resources
25 MeSH Terms
Trichostatin-A modulates claudin-1 mRNA stability through the modulation of Hu antigen R and tristetraprolin in colon cancer cells.
Sharma A, Bhat AA, Krishnan M, Singh AB, Dhawan P
(2013) Carcinogenesis 34: 2610-21
MeSH Terms: 3' Untranslated Regions, Base Sequence, Blotting, Western, Breast Neoplasms, Cells, Cultured, Chromatin Immunoprecipitation, Claudin-1, Colonic Neoplasms, ELAV Proteins, Epigenesis, Genetic, Female, Fluorescent Antibody Technique, Gene Expression Regulation, Neoplastic, Histone Deacetylase Inhibitors, Humans, Hydroxamic Acids, Immunoenzyme Techniques, Kidney, Molecular Sequence Data, Mutagenesis, Site-Directed, RNA, Messenger, Real-Time Polymerase Chain Reaction, Reverse Transcriptase Polymerase Chain Reaction, Tristetraprolin
Added March 7, 2014
0 Communities
2 Members
0 Resources
24 MeSH Terms
Evaluation of long-term transgene expression in piggyBac-modified human T lymphocytes.
Nakazawa Y, Saha S, Galvan DL, Huye L, Rollins L, Rooney CM, Wilson MH
(2013) J Immunother 36: 3-10
MeSH Terms: Antineoplastic Agents, Azacitidine, Cells, Cultured, Cytokines, DNA Transposable Elements, Gene Expression, Green Fluorescent Proteins, Histone Deacetylase Inhibitors, Humans, Hydroxamic Acids, Leukocytes, Mononuclear, Nerve Tissue Proteins, Receptors, Antigen, T-Cell, T-Lymphocytes, Transfection, Transgenes
Added August 22, 2013
0 Communities
1 Members
0 Resources
16 MeSH Terms
The coactivator role of histone deacetylase 3 in IL-1-signaling involves deacetylation of p65 NF-κB.
Ziesché E, Kettner-Buhrow D, Weber A, Wittwer T, Jurida L, Soelch J, Müller H, Newel D, Kronich P, Schneider H, Dittrich-Breiholz O, Bhaskara S, Hiebert SW, Hottiger MO, Li H, Burstein E, Schmitz ML, Kracht M
(2013) Nucleic Acids Res 41: 90-109
MeSH Terms: Acetylation, Animals, Cell Line, Chemokine CXCL2, Down-Regulation, Histone Deacetylase Inhibitors, Histone Deacetylases, Humans, Hydroxamic Acids, Interleukin-1, Interleukin-8, Mice, NF-kappa B, Phosphorylation, RNA Polymerase II, Signal Transduction, Transcription Factor RelA, Transcription, Genetic
Added March 26, 2014
2 Communities
1 Members
0 Resources
18 MeSH Terms
Role of HDAC3 on p53 expression and apoptosis in T cells of patients with multiple sclerosis.
Zhang F, Shi Y, Wang L, Sriram S
(2011) PLoS One 6: e16795
MeSH Terms: Adult, Apoptosis, Case-Control Studies, Dose-Response Relationship, Drug, Female, Gene Expression Regulation, Histone Deacetylase Inhibitors, Histone Deacetylases, Humans, Hydroxamic Acids, Kinetics, Leukocytes, Mononuclear, Male, Middle Aged, Multiple Sclerosis, Oligonucleotide Array Sequence Analysis, T-Lymphocytes, Tumor Suppressor Protein p53, Young Adult
Added April 18, 2017
0 Communities
1 Members
0 Resources
19 MeSH Terms
STAT6 activation in ulcerative colitis: a new target for prevention of IL-13-induced colon epithelial cell dysfunction.
Rosen MJ, Frey MR, Washington MK, Chaturvedi R, Kuhnhein LA, Matta P, Revetta FL, Wilson KT, Polk DB
(2011) Inflamm Bowel Dis 17: 2224-34
MeSH Terms: Apoptosis, Blotting, Western, Case-Control Studies, Cells, Cultured, Child, Claudins, Colitis, Ulcerative, Colon, Crohn Disease, Epithelial Cells, Female, Humans, Hydroxamic Acids, Immunoenzyme Techniques, Interleukin-13, Male, Phosphorylation, RNA, Messenger, RNA, Small Interfering, Real-Time Polymerase Chain Reaction, STAT6 Transcription Factor, Signal Transduction, Up-Regulation, Vorinostat
Added March 5, 2014
0 Communities
3 Members
0 Resources
24 MeSH Terms
Epigenetic silencing of somatostatin in gastric cancer.
Jackson K, Soutto M, Peng D, Hu T, Marshal D, El-Rifai W
(2011) Dig Dis Sci 56: 125-30
MeSH Terms: Adenocarcinoma, Antineoplastic Agents, Azacitidine, Biomarkers, Tumor, Cell Line, Tumor, DNA Methylation, Decitabine, Epigenesis, Genetic, Gene Expression Regulation, Neoplastic, Humans, Hydroxamic Acids, Methylation, Predictive Value of Tests, RNA, Messenger, Reproducibility of Results, Somatostatin, Stomach Neoplasms
Added July 26, 2012
1 Communities
1 Members
0 Resources
17 MeSH Terms