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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 20

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iNKT Cell Activation Exacerbates the Development of Huntington's Disease in R6/2 Transgenic Mice.
Park HJ, Lee SW, Im W, Kim M, Van Kaer L, Hong S
(2019) Mediators Inflamm 2019: 3540974
MeSH Terms: Animals, Brain, Cytokines, Disease Models, Animal, Disease Progression, Galactosylceramides, Genotype, Huntington Disease, Leukocytes, Lymphocyte Activation, Mice, Mice, Knockout, Natural Killer T-Cells
Added March 26, 2019
0 Communities
1 Members
0 Resources
13 MeSH Terms
Manganese and the Insulin-IGF Signaling Network in Huntington's Disease and Other Neurodegenerative Disorders.
Bryan MR, Bowman AB
(2017) Adv Neurobiol 18: 113-142
MeSH Terms: Alzheimer Disease, Amyotrophic Lateral Sclerosis, Animals, Autophagy, Brain, Disease Models, Animal, Humans, Huntingtin Protein, Huntington Disease, Insulin, Manganese, Mitochondria, Neostriatum, Neural Stem Cells, Neurodegenerative Diseases, Parkinson Disease, Reactive Oxygen Species, Signal Transduction, Somatomedins
Added April 11, 2018
0 Communities
1 Members
0 Resources
MeSH Terms
Defective Sphingosine-1-phosphate metabolism is a druggable target in Huntington's disease.
Di Pardo A, Amico E, Basit A, Armirotti A, Joshi P, Neely MD, Vuono R, Castaldo S, Digilio AF, Scalabrì F, Pepe G, Elifani F, Madonna M, Jeong SK, Park BM, D'Esposito M, Bowman AB, Barker RA, Maglione V
(2017) Sci Rep 7: 5280
MeSH Terms: Aged, Aldehyde-Lyases, Animals, Disease Models, Animal, Enzyme Inhibitors, Gene Expression Regulation, Humans, Huntington Disease, Lysophospholipids, Male, Mice, Molecular Targeted Therapy, Phosphotransferases (Alcohol Group Acceptor), Receptors, Lysosphingolipid, Sphingosine
Added April 11, 2018
0 Communities
1 Members
0 Resources
15 MeSH Terms
Reduced bioavailable manganese causes striatal urea cycle pathology in Huntington's disease mouse model.
Bichell TJV, Wegrzynowicz M, Tipps KG, Bradley EM, Uhouse MA, Bryan M, Horning K, Fisher N, Dudek K, Halbesma T, Umashanker P, Stubbs AD, Holt HK, Kwakye GF, Tidball AM, Colbran RJ, Aschner M, Neely MD, Di Pardo A, Maglione V, Osmand A, Bowman AB
(2017) Biochim Biophys Acta Mol Basis Dis 1863: 1596-1604
MeSH Terms: Animals, Arginase, Corpus Striatum, Disease Models, Animal, Huntington Disease, Male, Manganese, Mice, Neurons, Urea
Added April 26, 2017
0 Communities
2 Members
0 Resources
10 MeSH Terms
Embryonic Mutant Huntingtin Aggregate Formation in Mouse Models of Huntington's Disease.
Osmand AP, Bichell TJ, Bowman AB, Bates GP
(2016) J Huntingtons Dis 5: 343-346
MeSH Terms: Animals, Axons, Brain, Disease Models, Animal, Huntingtin Protein, Huntington Disease, Immunohistochemistry, Mice, Transgenic, Protein Aggregation, Pathological
Added April 26, 2017
0 Communities
1 Members
0 Resources
9 MeSH Terms
Genomic Instability Associated with p53 Knockdown in the Generation of Huntington's Disease Human Induced Pluripotent Stem Cells.
Tidball AM, Neely MD, Chamberlin R, Aboud AA, Kumar KK, Han B, Bryan MR, Aschner M, Ess KC, Bowman AB
(2016) PLoS One 11: e0150372
MeSH Terms: Adult, Aged, Cells, Cultured, DNA Damage, Gene Knockdown Techniques, Genomic Instability, Humans, Huntington Disease, Induced Pluripotent Stem Cells, Karyotyping, Middle Aged, Nucleic Acid Synthesis Inhibitors, Signal Transduction, Tumor Suppressor Protein p53, Young Adult, Zinostatin
Added August 18, 2016
0 Communities
2 Members
0 Resources
16 MeSH Terms
Allosteric activation of M4 muscarinic receptors improve behavioral and physiological alterations in early symptomatic YAC128 mice.
Pancani T, Foster DJ, Moehle MS, Bichell TJ, Bradley E, Bridges TM, Klar R, Poslusney M, Rook JM, Daniels JS, Niswender CM, Jones CK, Wood MR, Bowman AB, Lindsley CW, Xiang Z, Conn PJ
(2015) Proc Natl Acad Sci U S A 112: 14078-83
MeSH Terms: Allosteric Regulation, Animals, Brain, Fluorescence, Glutamic Acid, Huntington Disease, Immunohistochemistry, Mice, Mice, Mutant Strains, Pyridazines, Receptor, Muscarinic M4, Rotarod Performance Test, Synaptic Transmission, Thiophenes
Added February 15, 2016
0 Communities
5 Members
0 Resources
14 MeSH Terms
Novel BAC Mouse Model of Huntington's Disease with 225 CAG Repeats Exhibits an Early Widespread and Stable Degenerative Phenotype.
Wegrzynowicz M, Bichell TJ, Soares BD, Loth MK, McGlothan JS, Mori S, Alikhan FS, Hua K, Coughlin JM, Holt HK, Jetter CS, Pomper MG, Osmand AP, Guilarte TR, Bowman AB
(2015) J Huntingtons Dis 4: 17-36
MeSH Terms: Animals, Atrophy, Behavior, Animal, Brain, Chromosomes, Artificial, Bacterial, Disease Models, Animal, Disease Progression, Huntington Disease, Mice, Mice, Inbred C57BL, Mice, Transgenic, Neurons, Phenotype, Promoter Regions, Genetic, Serotonin Plasma Membrane Transport Proteins, Trinucleotide Repeat Expansion
Added February 15, 2016
1 Communities
1 Members
0 Resources
16 MeSH Terms
Manganese Is Essential for Neuronal Health.
Horning KJ, Caito SW, Tipps KG, Bowman AB, Aschner M
(2015) Annu Rev Nutr 35: 71-108
MeSH Terms: Arginase, Bile, Blood-Brain Barrier, Brain, Enzyme Activation, Glutamate-Ammonia Ligase, Health Status, Homeostasis, Humans, Huntington Disease, Intestinal Absorption, Manganese, Nervous System Diseases, Neurons, Parkinson Disease
Added February 15, 2016
0 Communities
1 Members
0 Resources
15 MeSH Terms
Untargeted metabolic profiling identifies interactions between Huntington's disease and neuronal manganese status.
Kumar KK, Goodwin CR, Uhouse MA, Bornhorst J, Schwerdtle T, Aschner M, McLean JA, Bowman AB
(2015) Metallomics 7: 363-70
MeSH Terms: Animals, Cell Line, Huntington Disease, Manganese, Metabolomics, Mice, Models, Biological, Neurons, Principal Component Analysis
Added February 3, 2015
1 Communities
1 Members
0 Resources
9 MeSH Terms