Manganese and the Insulin-IGF Signaling Network in Huntington's Disease and Other Neurodegenerative Disorders.
Bryan MR, Bowman AB
(2017) Adv Neurobiol 18
: 113-142MeSH Terms: Alzheimer Disease, Amyotrophic Lateral Sclerosis, Animals, Autophagy, Brain, Disease Models, Animal, Humans, Huntingtin Protein, Huntington Disease, Insulin, Manganese, Mitochondria, Neostriatum, Neural Stem Cells, Neurodegenerative Diseases, Parkinson Disease, Reactive Oxygen Species, Signal Transduction, SomatomedinsAdded April 11, 2018
Embryonic Mutant Huntingtin Aggregate Formation in Mouse Models of Huntington's Disease.
Osmand AP, Bichell TJ, Bowman AB, Bates GP
(2016) J Huntingtons Dis 5
: 343-346MeSH Terms: Animals, Axons, Brain, Disease Models, Animal, Huntingtin Protein, Huntington Disease, Immunohistochemistry, Mice, Transgenic, Protein Aggregation, PathologicalAdded April 26, 2017
9 MeSH Terms
BDNF and Huntingtin protein modifications by manganese: implications for striatal medium spiny neuron pathology in manganese neurotoxicity.
Stansfield KH, Bichell TJ, Bowman AB, Guilarte TR
(2014) J Neurochem 131
: 655-66MeSH Terms: Animals, Brain, Brain-Derived Neurotrophic Factor, Cells, Cultured, Cerebral Cortex, Corpus Striatum, Dendritic Spines, Disease Models, Animal, Dose-Response Relationship, Drug, Embryo, Mammalian, Gene Expression Regulation, Huntingtin Protein, Manganese, Manganese Poisoning, Mice, Microtubule-Associated Proteins, Nerve Tissue Proteins, Neurons, Nuclear Proteins, Phosphorylation, Rats, Rats, Sprague-DawleyAdded February 15, 2016
22 MeSH Terms
Changes in the striatal proteome of YAC128Q mice exhibit gene-environment interactions between mutant huntingtin and manganese.
Wegrzynowicz M, Holt HK, Friedman DB, Bowman AB
(2012) J Proteome Res 11
: 1118-32MeSH Terms: Analysis of Variance, Animals, Blotting, Western, Electrophoresis, Gel, Two-Dimensional, Gene-Environment Interaction, Huntingtin Protein, Male, Manganese, Mice, Mice, Transgenic, Neostriatum, Nerve Tissue Proteins, Nuclear Proteins, Principal Component Analysis, Proteome, ProteomicsAdded May 19, 2014
16 MeSH Terms
Altered manganese homeostasis and manganese toxicity in a Huntington's disease striatal cell model are not explained by defects in the iron transport system.
Williams BB, Kwakye GF, Wegrzynowicz M, Li D, Aschner M, Erikson KM, Bowman AB
(2010) Toxicol Sci 117
: 169-79MeSH Terms: Animals, Biological Transport, Cation Transport Proteins, Corpus Striatum, Disease Models, Animal, Homeostasis, Humans, Huntingtin Protein, Huntington Disease, Iron, Manganese, Mice, Nerve Tissue Proteins, Nuclear ProteinsAdded February 3, 2011
14 MeSH Terms
Disease-toxicant screen reveals a neuroprotective interaction between Huntington's disease and manganese exposure.
Williams BB, Li D, Wegrzynowicz M, Vadodaria BK, Anderson JG, Kwakye GF, Aschner M, Erikson KM, Bowman AB
(2010) J Neurochem 112
: 227-37MeSH Terms: Animals, Cattle, Cell Line, Cell Survival, Drug Evaluation, Preclinical, Humans, Huntingtin Protein, Huntington Disease, Manganese, Mice, Mice, Transgenic, Nerve Tissue Proteins, Nuclear ProteinsAdded June 9, 2010
13 MeSH Terms