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TGF-β and Diabetic Nephropathy: Lessons Learned Over the Past 20 Years.
Gewin LS
(2020) Am J Med Sci 359: 70-72
MeSH Terms: Diabetic Nephropathies, History, 20th Century, History, 21st Century, Humans, Kidney, Transforming Growth Factor beta1
Added March 18, 2020
0 Communities
1 Members
0 Resources
6 MeSH Terms
John A. Oates: A Founding Father of Clinical Pharmacology.
Roden DM
(2019) Clin Pharmacol Ther 106: 1155-1157
MeSH Terms: History, 20th Century, History, 21st Century, Pharmacology, Clinical
Added March 24, 2020
0 Communities
1 Members
0 Resources
3 MeSH Terms
The expanding roles and mechanisms of G protein-mediated presynaptic inhibition.
Zurawski Z, Yim YY, Alford S, Hamm HE
(2019) J Biol Chem 294: 1661-1670
MeSH Terms: Action Potentials, Biochemistry, History, 20th Century, History, 21st Century, Humans, Periodicals as Topic, Presynaptic Terminals, Receptors, G-Protein-Coupled, Synaptic Transmission
Show Abstract · Added March 24, 2020
Throughout the past five decades, tremendous advancements have been made in our understanding of G protein signaling and presynaptic inhibition, many of which were published in the under the tenure of Herb Tabor as Editor-in-Chief. Here, we identify these critical advances, including the formulation of the ternary complex model of G protein-coupled receptor signaling and the discovery of Gβγ as a critical signaling component of the heterotrimeric G protein, along with the nature of presynaptic inhibition and its physiological role. We provide an overview for the discovery and physiological relevance of the two known Gβγ-mediated mechanisms for presynaptic inhibition: first, the action of Gβγ on voltage-gated calcium channels to inhibit calcium influx to the presynaptic active zone and, second, the direct binding of Gβγ to the SNARE complex to displace synaptotagmin downstream of calcium entry, which has been demonstrated to be important in neurons and secretory cells. These two mechanisms act in tandem with each other in a synergistic manner to provide more complete spatiotemporal control over neurotransmitter release.
© 2019 Zurawski et al.
0 Communities
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MeSH Terms
Reflections on the early years of neonatology. William Oh: neonatal pioneer devoted his career to groundbreaking research, expanding patient care, and mentoring others.
Reese CN, Reese J
(2019) J Perinatol 39: 18-27
MeSH Terms: Clinical Competence, History, 20th Century, History, 21st Century, Humans, Mentoring, Neonatology, Philippines, Research, United States
Added November 26, 2018
0 Communities
1 Members
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9 MeSH Terms
2017 Presidential Address: Checking, Balancing, and Celebrating Diversity: Celebrating Some of the Women Who Paved the Way.
Cox NJ
(2018) Am J Hum Genet 102: 342-349
MeSH Terms: Biographies as Topic, Cultural Diversity, History, 20th Century, History, 21st Century, Human Genetics, Humans, Women
Added March 15, 2018
0 Communities
1 Members
0 Resources
7 MeSH Terms
Reflections on the early years of neonatology. Paul R. Swyer: the beginnings of Canadian neonatology at The Hospital for Sick Children in Toronto and insights into his early career.
Reese CN, Reese J
(2018) J Perinatol 38: 297-305
MeSH Terms: Awards and Prizes, History, 20th Century, History, 21st Century, Neonatology, Ontario
Added March 31, 2018
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1 Members
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5 MeSH Terms
Stephen Elledge and the DNA damage response.
Cortez D, Zhou Z, Sanchez Y
(2015) DNA Repair (Amst) 35: 156-7
MeSH Terms: Awards and Prizes, Biomedical Research, California, DNA Repair, Eukaryota, History, 21st Century, Massachusetts, Texas
Added February 4, 2016
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8 MeSH Terms
Acceptance of the 2015 Henry Baldwin Ward Medal: My Journey in Parasitology, and with Parasitologists.
Hillyer JF
(2015) J Parasitol 101: 623-6
MeSH Terms: Awards and Prizes, History, 20th Century, History, 21st Century, Parasitology, Research, Societies, Scientific, United States
Added February 5, 2016
0 Communities
1 Members
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7 MeSH Terms
Wayne Katon, MD.
Heckers S
(2015) JAMA Psychiatry 72: 621
MeSH Terms: History, 20th Century, History, 21st Century, Mental Health Services, Patient Care, Psychiatry, Washington
Added February 22, 2016
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1 Members
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6 MeSH Terms
Focus on Imaging Mass Spectrometry, Honoring Dr. Richard M. Caprioli, Recipient of the 2014 ASMS Award for a Distinguished Contribution in Mass Spectrometry.
Norris JL, Bierbaum VM
(2015) J Am Soc Mass Spectrom 26: 847-9
MeSH Terms: Animals, Awards and Prizes, Diagnostic Imaging, History, 20th Century, History, 21st Century, Humans, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization, United States
Added April 10, 2018
0 Communities
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MeSH Terms