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The Huntingtin-interacting protein SETD2/HYPB is an actin lysine methyltransferase.
Seervai RNH, Jangid RK, Karki M, Tripathi DN, Jung SY, Kearns SE, Verhey KJ, Cianfrocco MA, Millis BA, Tyska MJ, Mason FM, Rathmell WK, Park IY, Dere R, Walker CL
(2020) Sci Adv 6:
MeSH Terms: Actins, Cytoskeleton, GTP-Binding Proteins, Histone-Lysine N-Methyltransferase, Lysine, Methylation, Protein Processing, Post-Translational
Added April 27, 2021
0 Communities
1 Members
0 Resources
7 MeSH Terms
Haploinsufficiency for Microtubule Methylation Is an Early Driver of Genomic Instability in Renal Cell Carcinoma.
Chiang YC, Park IY, Terzo EA, Tripathi DN, Mason FM, Fahey CC, Karki M, Shuster CB, Sohn BH, Chowdhury P, Powell RT, Ohi R, Tsai YS, de Cubas AA, Khan A, Davis IJ, Strahl BD, Parker JS, Dere R, Walker CL, Rathmell WK
(2018) Cancer Res 78: 3135-3146
MeSH Terms: Animals, Carcinogenesis, Carcinoma, Renal Cell, Cell Line, Tumor, Chromosomes, Human, Pair 3, Fibroblasts, Gene Knockdown Techniques, Genomic Instability, Haploinsufficiency, Histone-Lysine N-Methyltransferase, Histones, Humans, Kidney Neoplasms, Kidney Tubules, Proximal, Lysine, Methylation, Mice, Micronuclei, Chromosome-Defective, Microtubules
Added October 30, 2019
0 Communities
1 Members
0 Resources
MeSH Terms
Set2 methyltransferase facilitates cell cycle progression by maintaining transcriptional fidelity.
Dronamraju R, Jha DK, Eser U, Adams AT, Dominguez D, Choudhury R, Chiang YC, Rathmell WK, Emanuele MJ, Churchman LS, Strahl BD
(2018) Nucleic Acids Res 46: 1331-1344
MeSH Terms: Anaphase-Promoting Complex-Cyclosome, Biological Evolution, Cdc20 Proteins, Cell Cycle, Gene Expression Regulation, Fungal, Histone-Lysine N-Methyltransferase, Histones, Humans, Lysine, Methylation, Methyltransferases, Nocodazole, Protein Processing, Post-Translational, Proteolysis, Saccharomyces cerevisiae, Saccharomyces cerevisiae Proteins, Transcription, Genetic, Tubulin Modulators
Added October 30, 2019
0 Communities
1 Members
0 Resources
MeSH Terms
Design, Synthesis, and Biological Activity of Substrate Competitive SMYD2 Inhibitors.
Cowen SD, Russell D, Dakin LA, Chen H, Larsen NA, Godin R, Throner S, Zheng X, Molina A, Wu J, Cheung T, Howard T, Garcia-Arenas R, Keen N, Pendleton CS, Pietenpol JA, Ferguson AD
(2016) J Med Chem 59: 11079-11097
MeSH Terms: Cell Line, Tumor, Cell Proliferation, Dose-Response Relationship, Drug, Drug Design, Enzyme Inhibitors, HCT116 Cells, Histone-Lysine N-Methyltransferase, Humans, Molecular Structure, Structure-Activity Relationship
Added April 9, 2017
1 Communities
1 Members
0 Resources
10 MeSH Terms
Structure/Function Analysis of Recurrent Mutations in SETD2 Protein Reveals a Critical and Conserved Role for a SET Domain Residue in Maintaining Protein Stability and Histone H3 Lys-36 Trimethylation.
Hacker KE, Fahey CC, Shinsky SA, Chiang YJ, DiFiore JV, Jha DK, Vo AH, Shavit JA, Davis IJ, Strahl BD, Rathmell WK
(2016) J Biol Chem 291: 21283-21295
MeSH Terms: Enzyme Stability, Histone-Lysine N-Methyltransferase, Histones, Humans, Methylation, Methyltransferases, Mutation, Neoplasm Proteins, Neoplasms, Saccharomyces cerevisiae, Saccharomyces cerevisiae Proteins, Structure-Activity Relationship
Added October 30, 2019
0 Communities
1 Members
0 Resources
MeSH Terms
Dual Chromatin and Cytoskeletal Remodeling by SETD2.
Park IY, Powell RT, Tripathi DN, Dere R, Ho TH, Blasius TL, Chiang YC, Davis IJ, Fahey CC, Hacker KE, Verhey KJ, Bedford MT, Jonasch E, Rathmell WK, Walker CL
(2016) Cell 166: 950-962
MeSH Terms: Cell Line, Tumor, Chromatin Assembly and Disassembly, Cytokinesis, Cytoskeleton, Genomic Instability, Histone Code, Histone-Lysine N-Methyltransferase, Histones, Humans, Lysine, Methylation, Microtubules, Mitosis, Protein Processing, Post-Translational, Tubulin
Added October 30, 2019
0 Communities
1 Members
0 Resources
MeSH Terms
The MYC-WDR5 Nexus and Cancer.
Thomas LR, Foshage AM, Weissmiller AM, Tansey WP
(2015) Cancer Res 75: 4012-5
MeSH Terms: Antineoplastic Agents, Basic Helix-Loop-Helix Leucine Zipper Transcription Factors, Chromatin Assembly and Disassembly, DNA, DNA Methylation, Drug Discovery, Epigenesis, Genetic, Gene Expression Regulation, Neoplastic, Genes, myc, Histone-Lysine N-Methyltransferase, Histones, Humans, Intracellular Signaling Peptides and Proteins, Models, Genetic, Molecular Targeted Therapy, Neoplasm Proteins, Neoplasms, Protein Binding, Proto-Oncogene Proteins c-myc, Repressor Proteins, Signal Transduction
Added March 26, 2019
0 Communities
1 Members
0 Resources
21 MeSH Terms
LASP-1: a nuclear hub for the UHRF1-DNMT1-G9a-Snail1 complex.
Duvall-Noelle N, Karwandyar A, Richmond A, Raman D
(2016) Oncogene 35: 1122-33
MeSH Terms: Active Transport, Cell Nucleus, Adaptor Proteins, Signal Transducing, Benzylamines, Breast Neoplasms, CCAAT-Enhancer-Binding Proteins, Cell Line, Tumor, Chemokine CXCL12, Cyclams, Cytoskeletal Proteins, DNA (Cytosine-5-)-Methyltransferase 1, DNA (Cytosine-5-)-Methyltransferases, Epigenesis, Genetic, Gene Knockdown Techniques, Heterocyclic Compounds, Histocompatibility Antigens, Histone-Lysine N-Methyltransferase, Histones, Humans, LIM Domain Proteins, Prognosis, Proteomics, Signal Transduction, Snail Family Transcription Factors, Transcription Factors, Tumor Microenvironment, Ubiquitin-Protein Ligases
Added May 20, 2015
2 Communities
2 Members
0 Resources
26 MeSH Terms
Variation in chromatin accessibility in human kidney cancer links H3K36 methyltransferase loss with widespread RNA processing defects.
Simon JM, Hacker KE, Singh D, Brannon AR, Parker JS, Weiser M, Ho TH, Kuan PF, Jonasch E, Furey TS, Prins JF, Lieb JD, Rathmell WK, Davis IJ
(2014) Genome Res 24: 241-50
MeSH Terms: Carcinoma, Renal Cell, Chromatin, DNA-Binding Proteins, Gene Expression Regulation, Neoplastic, Histone-Lysine N-Methyltransferase, Humans, Kidney Neoplasms, Mutation, Nuclear Proteins, RNA Processing, Post-Transcriptional, RNA Splicing, Transcription Factors, Tumor Suppressor Proteins, Ubiquitin Thiolesterase
Added October 17, 2015
0 Communities
1 Members
0 Resources
14 MeSH Terms
Epigenomic plasticity enables human pancreatic α to β cell reprogramming.
Bramswig NC, Everett LJ, Schug J, Dorrell C, Liu C, Luo Y, Streeter PR, Naji A, Grompe M, Kaestner KH
(2013) J Clin Invest 123: 1275-84
MeSH Terms: Animals, Cell Differentiation, Cell Separation, Cells, Cultured, Enzyme Inhibitors, Epigenesis, Genetic, Flow Cytometry, Gene Expression Profiling, Glucagon-Secreting Cells, Histone Methyltransferases, Histone-Lysine N-Methyltransferase, Histones, Humans, Insulin-Secreting Cells, Methylation, Mice, Molecular Sequence Annotation, Protein Processing, Post-Translational, Sequence Analysis, RNA, Transcriptome
Added June 5, 2013
0 Communities
0 Members
1 Resources
20 MeSH Terms