Regulation of the Pancreatic Exocrine Differentiation Program and Morphogenesis by Onecut 1/Hnf6.
Kropp PA, Zhu X, Gannon M
(2019) Cell Mol Gastroenterol Hepatol 7
: 841-856MeSH Terms: Acinar Cells, Animals, Animals, Newborn, Base Sequence, Cell Differentiation, Cell Proliferation, Embryo, Mammalian, Epithelium, Gene Expression Regulation, Developmental, Hepatocyte Nuclear Factor 6, Mice, Morphogenesis, Pancreas, ExocrineAdded March 29, 2019
13 MeSH Terms
Cooperative function of Pdx1 and Oc1 in multipotent pancreatic progenitors impacts postnatal islet maturation and adaptability.
Kropp PA, Dunn JC, Carboneau BA, Stoffers DA, Gannon M
(2018) Am J Physiol Endocrinol Metab 314
: E308-E321MeSH Terms: Adaptation, Physiological, Animals, Animals, Newborn, Cell Differentiation, Cells, Cultured, Diet, High-Fat, Gene Expression Regulation, Developmental, Glucose, Hepatocyte Nuclear Factor 6, Homeodomain Proteins, Insulin-Secreting Cells, Islets of Langerhans, Male, Mice, Mice, Transgenic, Multipotent Stem Cells, Organogenesis, Trans-ActivatorsAdded April 15, 2019
Threshold-Dependent Cooperativity of Pdx1 and Oc1 in Pancreatic Progenitors Establishes Competency for Endocrine Differentiation and β-Cell Function.
Henley KD, Stanescu DE, Kropp PA, Wright CVE, Won KJ, Stoffers DA, Gannon M
(2016) Cell Rep 15
: 2637-2650MeSH Terms: Animals, Basic Helix-Loop-Helix Transcription Factors, Cell Count, Cell Differentiation, Embryo, Mammalian, Gene Dosage, Gene Expression Regulation, Developmental, Gene Ontology, Gene Regulatory Networks, Glucose, Hepatocyte Nuclear Factor 6, Heterozygote, Homeodomain Proteins, Homeostasis, Insulin-Secreting Cells, Mice, Multigene Family, Nerve Tissue Proteins, Stem Cells, Trans-Activators, WeaningAdded July 5, 2016
21 MeSH Terms
Loss of HNF6 expression correlates with human pancreatic cancer progression.
Pekala KR, Ma X, Kropp PA, Petersen CP, Hudgens CW, Chung CH, Shi C, Merchant NB, Maitra A, Means AL, Gannon MA
(2014) Lab Invest 94
: 517-27MeSH Terms: Animals, Carcinoma, Pancreatic Ductal, Cell Line, Tumor, Disease Progression, Hepatocyte Nuclear Factor 6, Homeostasis, Humans, Liver Neoplasms, Experimental, Mice, Mice, Inbred C57BL, Pancreatic NeoplasmsAdded March 26, 2014
11 MeSH Terms
Intrahepatic bile duct regeneration in mice does not require Hnf6 or Notch signaling through Rbpj.
Walter TJ, Vanderpool C, Cast AE, Huppert SS
(2014) Am J Pathol 184
: 1479-88MeSH Terms: Animals, Bile Ducts, Intrahepatic, Epithelial Cells, Hepatocyte Nuclear Factor 6, Hepatocytes, Imaging, Three-Dimensional, Immunoglobulin J Recombination Signal Sequence-Binding Protein, Immunohistochemistry, Keratin-19, Mice, Knockout, Plant Lectins, Portal Vein, Receptors, Notch, Regeneration, SOX9 Transcription FactorAdded May 27, 2014
15 MeSH Terms
Onecut1 is essential for horizontal cell genesis and retinal integrity.
Wu F, Li R, Umino Y, Kaczynski TJ, Sapkota D, Li S, Xiang M, Fliesler SJ, Sherry DM, Gannon M, Solessio E, Mu X
(2013) J Neurosci 33
: 13053-65, 13065aMeSH Terms: Animals, Cell Count, Cell Differentiation, Cell Survival, Embryo, Mammalian, Eye Proteins, Gene Expression Regulation, Developmental, Green Fluorescent Proteins, Hepatocyte Nuclear Factor 6, Homeodomain Proteins, Mice, Mice, Inbred C57BL, Mice, Transgenic, Nerve Tissue Proteins, Neural Pathways, Neurogenesis, Neuroglia, Neurons, Protein Kinase C-alpha, Retina, Retinal Horizontal Cells, Synapses, Transcription FactorsAdded November 25, 2014
23 MeSH Terms
Role of the ductal transcription factors HNF6 and Sox9 in pancreatic acinar-to-ductal metaplasia.
Prévot PP, Simion A, Grimont A, Colletti M, Khalaileh A, Van den Steen G, Sempoux C, Xu X, Roelants V, Hald J, Bertrand L, Heimberg H, Konieczny SF, Dor Y, Lemaigre FP, Jacquemin P
(2012) Gut 61
: 1723-32MeSH Terms: Acinar Cells, Animals, Biomarkers, Tumor, Blotting, Western, Cell Transformation, Neoplastic, Cells, Cultured, Guinea Pigs, Hepatocyte Nuclear Factor 6, Humans, Metaplasia, Mice, Models, Animal, Pancreas, Real-Time Polymerase Chain Reaction, Reverse Transcriptase Polymerase Chain Reaction, SOX9 Transcription FactorAdded September 26, 2012
16 MeSH Terms
Renshaw cell interneuron specialization is controlled by a temporally restricted transcription factor program.
Stam FJ, Hendricks TJ, Zhang J, Geiman EJ, Francius C, Labosky PA, Clotman F, Goulding M
(2012) Development 139
: 179-90MeSH Terms: Animals, Bromodeoxyuridine, Cell Differentiation, Crosses, Genetic, Electrophysiology, Gene Expression Regulation, Developmental, Green Fluorescent Proteins, Hepatocyte Nuclear Factor 6, Homeodomain Proteins, Immunohistochemistry, Interneurons, Mice, Spinal Cord, Time Factors, Transcription FactorsAdded February 17, 2012
15 MeSH Terms
Genetic interactions between hepatocyte nuclear factor-6 and Notch signaling regulate mouse intrahepatic bile duct development in vivo.
Vanderpool C, Sparks EE, Huppert KA, Gannon M, Means AL, Huppert SS
(2012) Hepatology 55
: 233-43MeSH Terms: Animals, Bile Ducts, Intrahepatic, Cell Lineage, Cholestasis, Gene Expression Regulation, Developmental, Hepatocyte Nuclear Factor 1-beta, Hepatocyte Nuclear Factor 6, Hepatocytes, Immunoglobulin J Recombination Signal Sequence-Binding Protein, Immunoglobulin kappa-Chains, Integrases, Mice, Mice, Inbred Strains, Mice, Knockout, Receptors, Notch, SOX9 Transcription Factor, Signal TransductionAdded December 5, 2013
17 MeSH Terms
A new set of classifications for ductal plate malformations.
(2011) Hepatology 53
: 1795-7MeSH Terms: Animals, Bile Ducts, Intrahepatic, Biomarkers, Congenital Abnormalities, Disease Models, Animal, Hepatocyte Nuclear Factor 1-beta, Hepatocyte Nuclear Factor 4, Hepatocyte Nuclear Factor 6, Humans, Liver Diseases, Membrane Proteins, Mice, Mice, Knockout, Protein-Serine-Threonine Kinases, Receptor, Transforming Growth Factor-beta Type II, Receptors, Transforming Growth Factor beta, SOX9 Transcription FactorAdded July 16, 2011
17 MeSH Terms