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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 19

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Antagonistic epistasis of Hnf4α and FoxO1 metabolic networks through enhancer interactions in β-cell function.
Kuo T, Du W, Miyachi Y, Dadi PK, Jacobson DA, Segrè D, Accili D
(2021) Mol Metab 53: 101256
MeSH Terms: Animals, Epistasis, Genetic, Forkhead Box Protein O1, Hepatocyte Nuclear Factor 4, Insulin-Secreting Cells, Mice, Mice, Knockout, Mutation
Added June 14, 2021
0 Communities
1 Members
0 Resources
8 MeSH Terms
miR-30-HNF4γ and miR-194-NR2F2 regulatory networks contribute to the upregulation of metaplasia markers in the stomach.
Sousa JF, Nam KT, Petersen CP, Lee HJ, Yang HK, Kim WH, Goldenring JR
(2016) Gut 65: 914-24
MeSH Terms: Adenocarcinoma, Biomarkers, Tumor, COUP Transcription Factor II, Gastric Mucosa, Gene Expression Regulation, Neoplastic, Hepatocyte Nuclear Factor 4, Humans, Intercellular Signaling Peptides and Proteins, Metaplasia, MicroRNAs, Microfilament Proteins, Peptides, Stomach, Stomach Neoplasms, Transfection, Trefoil Factor-2, Trefoil Factor-3, Up-Regulation
Added September 28, 2015
0 Communities
1 Members
0 Resources
18 MeSH Terms
Proteogenomic characterization of human colon and rectal cancer.
Zhang B, Wang J, Wang X, Zhu J, Liu Q, Shi Z, Chambers MC, Zimmerman LJ, Shaddox KF, Kim S, Davies SR, Wang S, Wang P, Kinsinger CR, Rivers RC, Rodriguez H, Townsend RR, Ellis MJ, Carr SA, Tabb DL, Coffey RJ, Slebos RJ, Liebler DC, NCI CPTAC
(2014) Nature 513: 382-7
MeSH Terms: Chromosomes, Human, Pair 20, Colonic Neoplasms, CpG Islands, DNA Copy Number Variations, DNA Methylation, Genomics, Hepatocyte Nuclear Factor 4, Humans, Microsatellite Repeats, Mitochondrial Membrane Transport Proteins, Mitochondrial Precursor Protein Import Complex Proteins, Mutation, Missense, Neoplasm Proteins, Point Mutation, Proteome, Proteomics, Proto-Oncogene Mas, Proto-Oncogene Proteins pp60(c-src), RNA, Messenger, RNA, Neoplasm, Rectal Neoplasms, Transcriptome
Added December 4, 2014
0 Communities
3 Members
0 Resources
22 MeSH Terms
Genetic variants in transcription factors are associated with the pharmacokinetics and pharmacodynamics of metformin.
Goswami S, Yee SW, Stocker S, Mosley JD, Kubo M, Castro R, Mefford JA, Wen C, Liang X, Witte J, Brett C, Maeda S, Simpson MD, Hedderson MM, Davis RL, Roden DM, Giacomini KM, Savic RM
(2014) Clin Pharmacol Ther 96: 370-9
MeSH Terms: Adult, Aged, Aged, 80 and over, Biomarkers, Diabetes Mellitus, Type 2, Female, Genome-Wide Association Study, Glycated Hemoglobin A, Hepatocyte Nuclear Factor 4, Homozygote, Humans, Hypoglycemic Agents, Male, Metformin, Middle Aged, Models, Biological, Multivariate Analysis, PPAR alpha, Pharmacogenetics, Phenotype, Polymorphism, Single Nucleotide, Retrospective Studies, Sp1 Transcription Factor, Transcription Factors, Treatment Outcome, United States, Young Adult
Added June 26, 2014
0 Communities
1 Members
0 Resources
27 MeSH Terms
A new set of classifications for ductal plate malformations.
Huppert SS
(2011) Hepatology 53: 1795-7
MeSH Terms: Animals, Bile Ducts, Intrahepatic, Biomarkers, Congenital Abnormalities, Disease Models, Animal, Hepatocyte Nuclear Factor 1-beta, Hepatocyte Nuclear Factor 4, Hepatocyte Nuclear Factor 6, Humans, Liver Diseases, Membrane Proteins, Mice, Mice, Knockout, Protein Serine-Threonine Kinases, Receptor, Transforming Growth Factor-beta Type II, Receptors, Transforming Growth Factor beta, SOX9 Transcription Factor
Added July 16, 2011
1 Communities
1 Members
0 Resources
17 MeSH Terms
Hepatic hepatocyte nuclear factor 4α is essential for maintaining triglyceride and cholesterol homeostasis.
Yin L, Ma H, Ge X, Edwards PA, Zhang Y
(2011) Arterioscler Thromb Vasc Biol 31: 328-36
MeSH Terms: Adenoviridae, Animals, Cells, Cultured, Cholesterol, Cholesterol, HDL, Cholesterol, VLDL, Fatty Liver, Hepatocyte Nuclear Factor 4, Hepatocytes, Homeostasis, Lipid Metabolism, Mice, Mice, Inbred C57BL, Models, Animal, RNA, Small Interfering, Triglycerides
Added July 21, 2014
1 Communities
0 Members
0 Resources
16 MeSH Terms
Trans-10, cis-12-conjugated linoleic acid alters hepatic gene expression in a polygenic obese line of mice displaying hepatic lipidosis.
Ashwell MS, Ceddia RP, House RL, Cassady JP, Eisen EJ, Eling TE, Collins JB, Grissom SF, Odle J
(2010) J Nutr Biochem 21: 848-55
MeSH Terms: Animals, Fatty Liver, Gene Expression Profiling, Hepatocyte Nuclear Factor 4, Linoleic Acids, Conjugated, Liver, Male, Mice, Obesity
Added September 25, 2018
0 Communities
1 Members
0 Resources
MeSH Terms
Inter-individual variation in flavin-containing monooxygenase 3 in livers from Japanese: correlation with hepatic transcription factors.
Nagashima S, Shimizu M, Yano H, Murayama N, Kumai T, Kobayashi S, Guengerich FP, Yamazaki H
(2009) Drug Metab Pharmacokinet 24: 218-25
MeSH Terms: Asians, Benzodiazepines, Benzydamine, CCAAT-Binding Factor, Genetic Variation, Hepatocyte Nuclear Factor 4, Humans, Hydrogen-Ion Concentration, Microsomes, Liver, Olanzapine, Osmolar Concentration, Oxygenases, RNA, Messenger, S-Nitroso-N-Acetylpenicillamine, Sulfides
Added March 26, 2014
0 Communities
1 Members
0 Resources
15 MeSH Terms
Hepatocyte nuclear factor-4alpha is essential for glucose-stimulated insulin secretion by pancreatic beta-cells.
Miura A, Yamagata K, Kakei M, Hatakeyama H, Takahashi N, Fukui K, Nammo T, Yoneda K, Inoue Y, Sladek FM, Magnuson MA, Kasai H, Miyagawa J, Gonzalez FJ, Shimomura I
(2006) J Biol Chem 281: 5246-57
MeSH Terms: ATP-Binding Cassette Transporters, Adenosine Triphosphate, Animals, Arginine, Blood Glucose, Blotting, Western, Calcium, Cytosol, Exons, Female, Genotype, Glucose, Hepatocyte Nuclear Factor 4, Heterozygote, Immunohistochemistry, Insulin, Insulin Secretion, Insulin-Secreting Cells, Islets of Langerhans, Male, Mice, Mice, Inbred C57BL, Mice, Knockout, Microscopy, Fluorescence, Models, Genetic, Multidrug Resistance-Associated Proteins, Patch-Clamp Techniques, Polymerase Chain Reaction, Potassium, Potassium Channels, Inwardly Rectifying, Potassium Chloride, RNA, Messenger, Receptors, Drug, Reverse Transcriptase Polymerase Chain Reaction, Sulfonylurea Compounds, Sulfonylurea Receptors, Tissue Distribution, Transgenes
Added February 23, 2011
1 Communities
1 Members
0 Resources
38 MeSH Terms
Control of pancreas and liver gene expression by HNF transcription factors.
Odom DT, Zizlsperger N, Gordon DB, Bell GW, Rinaldi NJ, Murray HL, Volkert TL, Schreiber J, Rolfe PA, Gifford DK, Fraenkel E, Bell GI, Young RA
(2004) Science 303: 1378-81
MeSH Terms: Basic Helix-Loop-Helix Leucine Zipper Transcription Factors, Carbohydrate Metabolism, DNA-Binding Proteins, Diabetes Mellitus, Type 2, Gene Expression Profiling, Gene Expression Regulation, Genome, Human, Gluconeogenesis, Hepatocyte Nuclear Factor 1, Hepatocyte Nuclear Factor 1-alpha, Hepatocyte Nuclear Factor 1-beta, Hepatocyte Nuclear Factor 4, Hepatocyte Nuclear Factor 6, Hepatocytes, Homeodomain Proteins, Humans, Islets of Langerhans, Lipid Metabolism, Nuclear Proteins, Oligonucleotide Array Sequence Analysis, Phosphoproteins, Precipitin Tests, Promoter Regions, Genetic, RNA Polymerase II, Trans-Activators, Transcription Factors, Transcription, Genetic
Added April 19, 2011
0 Communities
0 Members
1 Resources
27 MeSH Terms