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Results: 1 to 10 of 27

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Ceapins block the unfolded protein response sensor ATF6α by inducing a neomorphic inter-organelle tether.
Torres SE, Gallagher CM, Plate L, Gupta M, Liem CR, Guo X, Tian R, Stroud RM, Kampmann M, Weissman JS, Walter P
(2019) Elife 8:
MeSH Terms: ATP-Binding Cassette Transporters, Activating Transcription Factor 6, CRISPR-Cas Systems, Endoplasmic Reticulum, HEK293 Cells, Hep G2 Cells, Humans, Organelles, Peroxisomes, Phenotype, Protein Binding, Small Molecule Libraries, Unfolded Protein Response
Added March 3, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
Systemic bile acids induce insulin resistance in a TGR5-independent manner.
Syring KE, Cyphert TJ, Beck TC, Flynn CR, Mignemi NA, McGuinness OP
(2019) Am J Physiol Endocrinol Metab 316: E782-E793
MeSH Terms: Animals, Bile Acids and Salts, Cholagogues and Choleretics, Cholic Acids, Deoxycholic Acid, Gene Expression Profiling, Gluconeogenesis, Glucose Clamp Technique, Hep G2 Cells, Hepatocytes, Humans, Insulin Resistance, Liver, Mice, Mice, Knockout, Obesity, Primary Cell Culture, Receptors, G-Protein-Coupled, Taurocholic Acid
Added April 15, 2019
0 Communities
1 Members
0 Resources
19 MeSH Terms
The Dihydroxy Metabolite of the Teratogen Thalidomide Causes Oxidative DNA Damage.
Wani TH, Chakrabarty A, Shibata N, Yamazaki H, Guengerich FP, Chowdhury G
(2017) Chem Res Toxicol 30: 1622-1628
MeSH Terms: Catalase, DNA Cleavage, DNA Damage, Free Radical Scavengers, HEK293 Cells, Hep G2 Cells, Human Umbilical Vein Endothelial Cells, Humans, Microscopy, Fluorescence, Plasmids, Poly(ADP-ribose) Polymerases, Reactive Oxygen Species, Teratogens, Thalidomide
Added March 14, 2018
0 Communities
1 Members
0 Resources
14 MeSH Terms
Multiresponsive Nanogels for Targeted Anticancer Drug Delivery.
Zhang Q, Colazo J, Berg D, Mugo SM, Serpe MJ
(2017) Mol Pharm 14: 2624-2628
MeSH Terms: Antineoplastic Agents, Cell Survival, Concanavalin A, Doxorubicin, Drug Carriers, Hep G2 Cells, Humans, Hydrogen-Ion Concentration, Nanogels, Nanoparticles, Polyethylene Glycols, Polyethyleneimine, Polymers
Added November 7, 2019
0 Communities
1 Members
0 Resources
13 MeSH Terms
Specificity of Protein Covalent Modification by the Electrophilic Proteasome Inhibitor Carfilzomib in Human Cells.
Federspiel JD, Codreanu SG, Goyal S, Albertolle ME, Lowe E, Teague J, Wong H, Guengerich FP, Liebler DC
(2016) Mol Cell Proteomics 15: 3233-3242
MeSH Terms: Cell Line, Tumor, Cholestanetriol 26-Monooxygenase, Click Chemistry, Glutathione Transferase, Hep G2 Cells, Humans, Molecular Structure, Oligopeptides, Proteasome Inhibitors, Tandem Mass Spectrometry
Added March 14, 2018
0 Communities
1 Members
0 Resources
10 MeSH Terms
An Efficient Approach to Evaluate Reporter Ion Behavior from MALDI-MS/MS Data for Quantification Studies Using Isobaric Tags.
Cologna SM, Crutchfield CA, Searle BC, Blank PS, Toth CL, Ely AM, Picache JA, Backlund PS, Wassif CA, Porter FD, Yergey AL
(2015) J Proteome Res 14: 4169-78
MeSH Terms: Complex Mixtures, Hep G2 Cells, Humans, Ions, Peptides, Proteolysis, Proteome, Proteomics, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization, Staining and Labeling, Tandem Mass Spectrometry, Trypsin
Added April 25, 2016
0 Communities
1 Members
0 Resources
12 MeSH Terms
Synergistic effect of pro-inflammatory TNFα and IL-17 in periostin mediated collagen deposition: potential role in liver fibrosis.
Amara S, Lopez K, Banan B, Brown SK, Whalen M, Myles E, Ivy MT, Johnson T, Schey KL, Tiriveedhi V
(2015) Mol Immunol 64: 26-35
MeSH Terms: Cell Adhesion Molecules, Collagen Type I, DNA, Neoplasm, Fibroblasts, Hep G2 Cells, Humans, Inflammation Mediators, Interleukin-17, Liver Cirrhosis, Promoter Regions, Genetic, Protein Binding, Proto-Oncogene Proteins c-jun, STAT3 Transcription Factor, Transcription, Genetic, Tumor Necrosis Factor-alpha
Added February 12, 2015
0 Communities
1 Members
0 Resources
15 MeSH Terms
ATF6 activation reduces the secretion and extracellular aggregation of destabilized variants of an amyloidogenic protein.
Chen JJ, Genereux JC, Qu S, Hulleman JD, Shoulders MD, Wiseman RL
(2014) Chem Biol 21: 1564-74
MeSH Terms: ADP-Ribosylation Factor 6, ADP-Ribosylation Factors, Amino Acid Substitution, Endoplasmic Reticulum, HEK293 Cells, Hep G2 Cells, Humans, Kinetics, Prealbumin, Protein Stability, Recombinant Fusion Proteins, Tetrahydrofolate Dehydrogenase, Transfection, Unfolded Protein Response
Added December 4, 2014
1 Communities
0 Members
0 Resources
14 MeSH Terms
PCSK9 is a critical regulator of the innate immune response and septic shock outcome.
Walley KR, Thain KR, Russell JA, Reilly MP, Meyer NJ, Ferguson JF, Christie JD, Nakada TA, Fjell CD, Thair SA, Cirstea MS, Boyd JH
(2014) Sci Transl Med 6: 258ra143
MeSH Terms: Animals, Disease Models, Animal, Genetic Variation, Hep G2 Cells, Humans, Immunity, Innate, Lipopolysaccharides, Male, Mice, Inbred C57BL, Mice, Knockout, Proprotein Convertase 9, Proprotein Convertases, Serine Endopeptidases, Shock, Septic
Added January 20, 2015
0 Communities
1 Members
0 Resources
14 MeSH Terms
A polymorphism in HLA-G modifies statin benefit in asthma.
Naidoo D, Wu AC, Brilliant MH, Denny J, Ingram C, Kitchner TE, Linneman JG, McGeachie MJ, Roden DM, Shaffer CM, Shah A, Weeke P, Weiss ST, Xu H, Medina MW
(2015) Pharmacogenomics J 15: 272-7
MeSH Terms: 3' Untranslated Regions, Alleles, Asthma, Cell Line, Tumor, Female, HLA-G Antigens, Hep G2 Cells, Humans, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Male, MicroRNAs, Middle Aged, Polymorphism, Single Nucleotide, Risk
Added March 24, 2020
0 Communities
1 Members
0 Resources
MeSH Terms