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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 12

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Identification and characterization of ML352: a novel, noncompetitive inhibitor of the presynaptic choline transporter.
Ennis EA, Wright J, Retzlaff CL, McManus OB, Lin Z, Huang X, Wu M, Li M, Daniels JS, Lindsley CW, Hopkins CR, Blakely RD
(2015) ACS Chem Neurosci 6: 417-27
MeSH Terms: Animals, Benzamides, Choline, Dose-Response Relationship, Drug, Enzyme Inhibitors, Gene Expression Regulation, HEK293 Cells, Hemicholinium 3, Humans, Isoxazoles, Male, Membrane Potentials, Membrane Transport Proteins, Mice, Mice, Inbred C57BL, Models, Biological, Mutation, Neural Inhibition, Prosencephalon, Protein Binding, Rats, Rats, Sprague-Dawley, Synaptosomes
Added February 12, 2015
0 Communities
1 Members
0 Resources
23 MeSH Terms
Transgenic overexpression of the presynaptic choline transporter elevates acetylcholine levels and augments motor endurance.
Holmstrand EC, Lund D, Cherian AK, Wright J, Martin RF, Ennis EA, Stanwood GD, Sarter M, Blakely RD
(2014) Neurochem Int 73: 217-28
MeSH Terms: Acetylcholine, Animals, Behavior, Animal, Choline, Cholinergic Agents, Chromosomes, Artificial, Bacterial, Gene Dosage, Hemicholinium 3, Membrane Transport Proteins, Mice, Mice, Inbred C57BL, Mice, Transgenic, Physical Endurance, Receptors, Presynaptic, Synaptosomes
Added December 2, 2013
1 Communities
2 Members
0 Resources
15 MeSH Terms
Cognitive effects of dopamine depletion in the context of diminished acetylcholine signaling capacity in mice.
Zurkovsky L, Bychkov E, Tsakem EL, Siedlecki C, Blakely RD, Gurevich EV
(2013) Dis Model Mech 6: 171-83
MeSH Terms: Acetylcholine, Animals, Cholinergic Agents, Cognition Disorders, Dementia, Disease Models, Animal, Dopamine, Hemicholinium 3, Humans, Male, Membrane Transport Proteins, Memory, Mice, Mice, Inbred C57BL, Mice, Knockout, Parkinsonian Disorders, Signal Transduction
Added July 10, 2013
1 Communities
1 Members
0 Resources
17 MeSH Terms
Deficits in acetylcholine homeostasis, receptors and behaviors in choline transporter heterozygous mice.
Bazalakova MH, Wright J, Schneble EJ, McDonald MP, Heilman CJ, Levey AI, Blakely RD
(2007) Genes Brain Behav 6: 411-24
MeSH Terms: Acetylcholine, Animals, Anxiety, Brain, Cholinergic Agents, Exploratory Behavior, Hemicholinium 3, Heterozygote, Maze Learning, Membrane Transport Proteins, Mice, Mice, Inbred C57BL, Mice, Knockout, Motor Activity, Receptors, Muscarinic, Rotarod Performance Test, Scopolamine, Spatial Behavior
Added July 10, 2013
1 Communities
2 Members
0 Resources
18 MeSH Terms
Na+, Cl-, and pH dependence of the human choline transporter (hCHT) in Xenopus oocytes: the proton inactivation hypothesis of hCHT in synaptic vesicles.
Iwamoto H, Blakely RD, De Felice LJ
(2006) J Neurosci 26: 9851-9
MeSH Terms: Acetylcholine, Animals, Biological Transport, Chlorides, Choline, Female, Hemicholinium 3, Humans, Membrane Potentials, Membrane Transport Proteins, Models, Neurological, Oocytes, Patch-Clamp Techniques, Protons, Recombinant Fusion Proteins, Sodium, Symporters, Synaptic Vesicles, Xenopus laevis
Added July 10, 2013
1 Communities
2 Members
0 Resources
19 MeSH Terms
The Caenorhabditis elegans choline transporter CHO-1 sustains acetylcholine synthesis and motor function in an activity-dependent manner.
Matthies DS, Fleming PA, Wilkes DM, Blakely RD
(2006) J Neurosci 26: 6200-12
MeSH Terms: Acetylcholine, Adaptation, Physiological, Animals, Animals, Genetically Modified, Binding, Competitive, Biological Transport, Caenorhabditis elegans, Caenorhabditis elegans Proteins, Cells, Cultured, Choline, Cholinergic Agents, Electrophysiology, Gene Deletion, Green Fluorescent Proteins, Hemicholinium 3, Membrane Transport Proteins, Motor Activity, Nerve Tissue Proteins, Recombinant Fusion Proteins, Signal Transduction, Synapses, Tissue Distribution
Added July 10, 2013
1 Communities
1 Members
0 Resources
22 MeSH Terms
Lethal impairment of cholinergic neurotransmission in hemicholinium-3-sensitive choline transporter knockout mice.
Ferguson SM, Bazalakova M, Savchenko V, Tapia JC, Wright J, Blakely RD
(2004) Proc Natl Acad Sci U S A 101: 8762-7
MeSH Terms: Acetylcholine, Animals, Brain, Choline O-Acetyltransferase, Cholinergic Agents, Hemicholinium 3, In Vitro Techniques, Membrane Transport Proteins, Mice, Mice, Knockout, Motor Neurons, Neuromuscular Junction, Phenotype, Synaptic Transmission, Synaptosomes
Added July 10, 2013
2 Communities
1 Members
0 Resources
15 MeSH Terms
The choline transporter resurfaces: new roles for synaptic vesicles?
Ferguson SM, Blakely RD
(2004) Mol Interv 4: 22-37
MeSH Terms: Acetylcholine, Animals, Cell Membrane, Choline, Cholinergic Agents, Hemicholinium 3, Humans, Membrane Transport Proteins, Neurons, Presynaptic Terminals, Synaptic Transmission, Synaptic Vesicles
Added July 10, 2013
1 Communities
1 Members
0 Resources
12 MeSH Terms
Molecular cloning and characterization of a murine hemicholinium-3-sensitive choline transporter.
Apparsundaram S, Ferguson SM, Blakely RD
(2001) Biochem Soc Trans 29: 711-6
MeSH Terms: Animals, Blotting, Northern, CHO Cells, Cholinergic Agents, Cricetinae, DNA, Complementary, Dose-Response Relationship, Drug, Hemicholinium 3, Kinetics, Membrane Transport Proteins, Mice, Protein Binding, RNA, Messenger, Reverse Transcriptase Polymerase Chain Reaction
Added July 10, 2013
1 Communities
1 Members
0 Resources
14 MeSH Terms
Molecular cloning of a human, hemicholinium-3-sensitive choline transporter.
Apparsundaram S, Ferguson SM, George AL, Blakely RD
(2000) Biochem Biophys Res Commun 276: 862-7
MeSH Terms: Amino Acid Sequence, Animals, Binding Sites, Biological Transport, COS Cells, Carrier Proteins, Choline, Chromosomes, Human, Pair 2, Cloning, Molecular, Hemicholinium 3, Humans, Ligands, Membrane Transport Proteins, Molecular Sequence Data, Oocytes, Protein Binding, RNA, Messenger, Radiation Hybrid Mapping, Sequence Homology, Amino Acid, Transfection, Xenopus laevis
Added July 10, 2013
1 Communities
1 Members
0 Resources
21 MeSH Terms