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Autochthonous tumors driven by loss have an ongoing requirement for the RBP2 histone demethylase.
McBrayer SK, Olenchock BA, DiNatale GJ, Shi DD, Khanal J, Jennings RB, Novak JS, Oser MG, Robbins AK, Modiste R, Bonal D, Moslehi J, Bronson RT, Neuberg D, Nguyen QD, Signoretti S, Losman JA, Kaelin WG
(2018) Proc Natl Acad Sci U S A 115: E3741-E3748
MeSH Terms: Alleles, Animals, DNA-Binding Proteins, Echocardiography, Enzyme Activation, Fibroblasts, Genes, Retinoblastoma, Heart Septal Defects, Histone Code, Integrases, Jumonji Domain-Containing Histone Demethylases, Mice, Mice, Inbred C57BL, Molecular Targeted Therapy, Neoplasm Proteins, Pituitary Neoplasms, Recombinant Fusion Proteins, Retinoblastoma Protein, Tamoxifen, Thyroid Neoplasms, Transgenes
Added April 22, 2018
0 Communities
1 Members
0 Resources
21 MeSH Terms
Imbalanced expression of Vcan mRNA splice form proteins alters heart morphology and cellular protein profiles.
Burns TA, Dours-Zimmermann MT, Zimmermann DR, Krug EL, Comte-Walters S, Reyes L, Davis MA, Schey KL, Schwacke JH, Kern CB, Mjaatvedt CH
(2014) PLoS One 9: e89133
MeSH Terms: Animals, Aorta, Extracellular Matrix, Female, Gene Expression Regulation, Heart, Heart Septal Defects, Heart Valves, Mice, Myocardium, Pregnancy, Protein Isoforms, Proteomics, RNA, Messenger, Versicans
Added May 27, 2014
0 Communities
1 Members
0 Resources
15 MeSH Terms
A 64-year-old man with refractory hypoxemia in cardiogenic shock.
Cawcutt KA, Wilson ME, Carter KJ, Maldonado F
(2013) Chest 143: 1819-1821
MeSH Terms: Comorbidity, Coronary Angiography, Diagnosis, Differential, Echocardiography, Fatal Outcome, Heart Septal Defects, Ventricular, Heart-Assist Devices, Humans, Male, Middle Aged, Myocardial Infarction, Oximetry, Shock, Cardiogenic, Stents
Added February 1, 2016
0 Communities
1 Members
0 Resources
14 MeSH Terms
Genome-wide association study of multiple congenital heart disease phenotypes identifies a susceptibility locus for atrial septal defect at chromosome 4p16.
Cordell HJ, Bentham J, Topf A, Zelenika D, Heath S, Mamasoula C, Cosgrove C, Blue G, Granados-Riveron J, Setchfield K, Thornborough C, Breckpot J, Soemedi R, Martin R, Rahman TJ, Hall D, van Engelen K, Moorman AF, Zwinderman AH, Barnett P, Koopmann TT, Adriaens ME, Varro A, George AL, dos Remedios C, Bishopric NH, Bezzina CR, O'Sullivan J, Gewillig M, Bu'Lock FA, Winlaw D, Bhattacharya S, Devriendt K, Brook JD, Mulder BJ, Mital S, Postma AV, Lathrop GM, Farrall M, Goodship JA, Keavney BD
(2013) Nat Genet 45: 822-4
MeSH Terms: Abnormalities, Multiple, Animals, Case-Control Studies, Chromosomes, Human, Pair 4, Cohort Studies, Female, Genetic Loci, Genetic Predisposition to Disease, Genome-Wide Association Study, Genotype, Heart Defects, Congenital, Heart Diseases, Heart Septal Defects, Atrial, Humans, Male, Mice, Phenotype
Added March 7, 2014
0 Communities
1 Members
0 Resources
17 MeSH Terms
Congenital heart disease reminiscent of partial trisomy 2p syndrome in mice transgenic for the transcription factor Lbh.
Briegel KJ, Baldwin HS, Epstein JA, Joyner AL
(2005) Development 132: 3305-16
MeSH Terms: Animals, Cell Cycle Proteins, Chromosome Mapping, Heart, Heart Defects, Congenital, Heart Septal Defects, Heart Septum, Heart Ventricles, Mice, Mice, Transgenic, Muscle Proteins, Myocardium, Nuclear Proteins, Phenotype, Promoter Regions, Genetic, Repressor Proteins, Transcription Factors, Trisomy
Added June 11, 2010
1 Communities
1 Members
0 Resources
18 MeSH Terms
The mammalian Tolloid-like 1 gene, Tll1, is necessary for normal septation and positioning of the heart.
Clark TG, Conway SJ, Scott IC, Labosky PA, Winnier G, Bundy J, Hogan BL, Greenspan DS
(1999) Development 126: 2631-42
MeSH Terms: Animals, Bone Morphogenetic Protein 1, Bone Morphogenetic Proteins, Female, Fetal Death, Gene Expression Regulation, Developmental, Heart, Heart Defects, Congenital, Heart Septal Defects, Atrial, Heart Septal Defects, Ventricular, Heart Ventricles, Homozygote, Male, Metalloendopeptidases, Metalloproteases, Mice, Mice, Inbred C57BL, Mice, Mutant Strains, Myocardium, Phenotype, Proteins, Recombination, Genetic, Tolloid-Like Metalloproteinases
Added July 20, 2010
1 Communities
1 Members
0 Resources
23 MeSH Terms
Comparison of biplane and single plane left ventricular volumes in atrial septal defect.
Fraker TD, Wise NK, Harrell FE, Behar VS
(1980) Cathet Cardiovasc Diagn 6: 39-48
MeSH Terms: Cardiac Catheterization, Cardiac Volume, Cineangiography, Heart Septal Defects, Atrial, Heart Ventricles, Humans, Mathematics, Myocardial Contraction
Added February 28, 2014
0 Communities
1 Members
0 Resources
8 MeSH Terms