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Safety assessment of trimoniums as used in cosmetics.
Becker LC, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler D, Marks JG, Shank RC, Slaga TJ, Snyder PW, Andersen FA
(2012) Int J Toxicol 31: 296S-341S
MeSH Terms: Animals, Consumer Product Safety, Hair Preparations, Humans, Irritants, Polymers, Quaternary Ammonium Compounds, Risk Assessment, Structure-Activity Relationship, Toxicity Tests
Show Abstract · Added March 20, 2014
Quaternary ammonium salts, including alkyl chain, alkanol, and polymer derivatives (trimoniums) are used in cosmetics mainly as surfactant-cleansing agents, hair-conditioning agents, and antistatic agents.  The Cosmetic Ingredient Review Expert Panel reviewed the relevant animal and human data and noted gaps in the available safety data for some of the trimomiums.  The available data on many of the trimoniums are sufficient, however, and similar structural activity relationships, functions in cosmetics, and cosmetic product usage supported extending these data to the entire group.  These ingredients were determined to be safe in the present practices of use and concentration when formulated to be nonirritating.
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