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Results: 1 to 10 of 14

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Efficacy of the novel parainfluenza virus haemagglutinin-neuraminidase inhibitor BCX 2798 in mice - further evaluation.
Alymova IV, Watanabe M, Boyd KL, Chand P, Babu YS, Portner A
(2009) Antivir Ther 14: 891-8
MeSH Terms: Administration, Intranasal, Animals, Azides, Cell Line, Dose-Response Relationship, Drug, Enzyme Inhibitors, Female, HN Protein, Hexuronic Acids, Humans, Macaca mulatta, Mice, Parainfluenza Virus 1, Human, Premedication, Respirovirus Infections, Treatment Outcome
Added March 20, 2014
0 Communities
1 Members
0 Resources
16 MeSH Terms
Loss of the N-linked glycan at residue 173 of human parainfluenza virus type 1 hemagglutinin-neuraminidase exposes a second receptor-binding site.
Alymova IV, Taylor G, Mishin VP, Watanabe M, Murti KG, Boyd K, Chand P, Babu YS, Portner A
(2008) J Virol 82: 8400-10
MeSH Terms: Binding Sites, Cell Line, Tumor, HN Protein, Humans, Kinetics, Models, Molecular, Mutation, Parainfluenza Virus 1, Human, Receptors, Virus
Added March 5, 2014
0 Communities
1 Members
0 Resources
9 MeSH Terms
The novel parainfluenza virus hemagglutinin-neuraminidase inhibitor BCX 2798 prevents lethal synergism between a paramyxovirus and Streptococcus pneumoniae.
Alymova IV, Portner A, Takimoto T, Boyd KL, Babu YS, McCullers JA
(2005) Antimicrob Agents Chemother 49: 398-405
MeSH Terms: Animals, Azides, Disease Models, Animal, HN Protein, Hexuronic Acids, Humans, Lung, Mice, Parainfluenza Virus 1, Human, Pneumonia, Pneumococcal, Respirovirus Infections, Sendai virus, Streptococcus pneumoniae
Added March 5, 2014
0 Communities
1 Members
0 Resources
13 MeSH Terms
Passive IgA monoclonal antibody is no more effective than IgG at protecting mice from mucosal challenge with respiratory syncytial virus.
Fisher RG, Crowe JE, Johnson TR, Tang YW, Graham BS
(1999) J Infect Dis 180: 1324-7
MeSH Terms: Administration, Intranasal, Animals, Antibodies, Monoclonal, Antibody Specificity, Female, HN Protein, Humans, Immunity, Mucosal, Immunization, Passive, Immunoglobulin A, Immunoglobulin G, Mice, Mice, Inbred BALB C, Respiratory Mucosa, Respiratory Syncytial Virus Infections, Respiratory Syncytial Virus, Human, Specific Pathogen-Free Organisms, Tumor Cells, Cultured, Viral Envelope Proteins, Viral Proteins, Virus Replication
Added August 6, 2012
0 Communities
1 Members
0 Resources
21 MeSH Terms
RhoA interacts with the fusion glycoprotein of respiratory syncytial virus and facilitates virus-induced syncytium formation.
Pastey MK, Crowe JE, Graham BS
(1999) J Virol 73: 7262-70
MeSH Terms: Amino Acid Sequence, Binding Sites, Chromosome Mapping, Cloning, Molecular, DNA, Complementary, Enzyme-Linked Immunosorbent Assay, GTP Phosphohydrolases, GTP-Binding Proteins, Giant Cells, HN Protein, HeLa Cells, Humans, Molecular Sequence Data, Precipitin Tests, Respiratory Syncytial Virus, Human, Saccharomyces cerevisiae, Tumor Cells, Cultured, Viral Envelope Proteins, Viral Proteins, rhoA GTP-Binding Protein
Added August 6, 2012
0 Communities
1 Members
0 Resources
20 MeSH Terms
Addition of a missense mutation present in the L gene of respiratory syncytial virus (RSV) cpts530/1030 to RSV vaccine candidate cpts248/404 increases its attenuation and temperature sensitivity.
Whitehead SS, Firestone CY, Karron RA, Crowe JE, Elkins WR, Collins PL, Murphy BR
(1999) J Virol 73: 871-7
MeSH Terms: Animals, Child, Preschool, Chlorocebus aethiops, Double-Blind Method, HN Protein, Humans, Infant, Mice, Mice, Inbred BALB C, Mutation, Missense, Pan troglodytes, Respiratory Syncytial Virus, Human, Sequence Analysis, DNA, Temperature, Tumor Cells, Cultured, Vaccines, Attenuated, Vero Cells, Viral Envelope Proteins, Viral Proteins, Viral Vaccines, Virus Replication
Added August 6, 2012
0 Communities
1 Members
0 Resources
21 MeSH Terms
Isolation of a second recombinant human respiratory syncytial virus monoclonal antibody fragment (Fab RSVF2-5) that exhibits therapeutic efficacy in vivo.
Crowe JE, Gilmour PS, Murphy BR, Chanock RM, Duan L, Pomerantz RJ, Pilkington GR
(1998) J Infect Dis 177: 1073-6
MeSH Terms: Animals, Antibodies, Monoclonal, Antibodies, Monoclonal, Humanized, Antibodies, Viral, Antigens, Viral, Female, HN Protein, Immunoglobulin Fab Fragments, Lung, Mice, Mice, Inbred BALB C, Molecular Sequence Data, Neutralization Tests, Polymerase Chain Reaction, Recombinant Fusion Proteins, Respiratory Syncytial Virus Infections, Respiratory Syncytial Virus, Human, Sequence Analysis, DNA, Specific Pathogen-Free Organisms, Viral Envelope Proteins, Viral Proteins
Added August 6, 2012
0 Communities
1 Members
0 Resources
21 MeSH Terms
The temperature-sensitive (ts) phenotype of a cold-passaged (cp) live attenuated respiratory syncytial virus vaccine candidate, designated cpts530, results from a single amino acid substitution in the L protein.
Juhasz K, Whitehead SS, Bui PT, Biggs JM, Crowe JE, Boulanger CA, Collins PL, Murphy BR
(1997) J Virol 71: 5814-9
MeSH Terms: HN Protein, Mutation, Respiratory Syncytial Virus, Human, Temperature, Vaccines, Attenuated, Vaccines, Synthetic, Viral Envelope Proteins, Viral Proteins, Viral Vaccines
Added August 6, 2012
0 Communities
1 Members
0 Resources
9 MeSH Terms
A comparison in chimpanzees of the immunogenicity and efficacy of live attenuated respiratory syncytial virus (RSV) temperature-sensitive mutant vaccines and vaccinia virus recombinants that express the surface glycoproteins of RSV.
Crowe JE, Collins PL, London WT, Chanock RM, Murphy BR
(1993) Vaccine 11: 1395-404
MeSH Terms: Animals, Female, HN Protein, Humans, Male, Membrane Glycoproteins, Mutation, Pan troglodytes, Respiratory Syncytial Viruses, Sensitivity and Specificity, Temperature, Vaccines, Attenuated, Vaccines, Synthetic, Vaccinia virus, Viral Envelope Proteins, Viral Proteins, Viral Vaccines
Added August 6, 2012
0 Communities
1 Members
0 Resources
17 MeSH Terms
Cytotoxic T cells specific for a single peptide on the M2 protein of respiratory syncytial virus are the sole mediators of resistance induced by immunization with M2 encoded by a recombinant vaccinia virus.
Kulkarni AB, Collins PL, Bacik I, Yewdell JW, Bennink JR, Crowe JE, Murphy BR
(1995) J Virol 69: 1261-4
MeSH Terms: Animals, Antigens, Viral, Base Sequence, Female, HN Protein, Immunization, Mice, Mice, Inbred BALB C, Molecular Sequence Data, Respiratory Syncytial Viruses, T-Lymphocytes, Cytotoxic, Vaccines, Synthetic, Vaccinia virus, Viral Envelope Proteins, Viral Proteins, Viral Vaccines
Added August 6, 2012
0 Communities
1 Members
0 Resources
16 MeSH Terms