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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 10

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Surface-Matrix Screening Identifies Semi-specific Interactions that Improve Potency of a Near Pan-reactive HIV-1-Neutralizing Antibody.
Kwon YD, Chuang GY, Zhang B, Bailer RT, Doria-Rose NA, Gindin TS, Lin B, Louder MK, McKee K, O'Dell S, Pegu A, Schmidt SD, Asokan M, Chen X, Choe M, Georgiev IS, Jin V, Pancera M, Rawi R, Wang K, Chaudhuri R, Kueltzo LA, Manceva SD, Todd JP, Scorpio DG, Kim M, Reinherz EL, Wagh K, Korber BM, Connors M, Shapiro L, Mascola JR, Kwong PD
(2018) Cell Rep 22: 1798-1809
MeSH Terms: Antibodies, Neutralizing, Cell Membrane, HIV Antibodies, HIV Envelope Protein gp41, HIV-1, Half-Life, Humans, Neutralization Tests, Polysaccharides, Protein Binding
Added March 14, 2018
0 Communities
1 Members
0 Resources
10 MeSH Terms
Human Antibodies that Recognize Novel Immunodominant Quaternary Epitopes on the HIV-1 Env Protein.
Hicar MD, Chen X, Sulli C, Barnes T, Goodman J, Sojar H, Briney B, Willis J, Chukwuma VU, Kalams SA, Doranz BJ, Spearman P, Crowe JE
(2016) PLoS One 11: e0158861
MeSH Terms: Antibodies, Monoclonal, Antibodies, Neutralizing, B-Lymphocytes, HIV Antibodies, HIV Envelope Protein gp41, HIV Infections, HIV-1, Humans, Immunodominant Epitopes, Protein Domains, Recombinant Proteins, env Gene Products, Human Immunodeficiency Virus
Added April 13, 2017
0 Communities
1 Members
0 Resources
12 MeSH Terms
Fusion peptide of HIV-1 as a site of vulnerability to neutralizing antibody.
Kong R, Xu K, Zhou T, Acharya P, Lemmin T, Liu K, Ozorowski G, Soto C, Taft JD, Bailer RT, Cale EM, Chen L, Choi CW, Chuang GY, Doria-Rose NA, Druz A, Georgiev IS, Gorman J, Huang J, Joyce MG, Louder MK, Ma X, McKee K, O'Dell S, Pancera M, Yang Y, Blanchard SC, Mothes W, Burton DR, Koff WC, Connors M, Ward AB, Kwong PD, Mascola JR
(2016) Science 352: 828-33
MeSH Terms: AIDS Vaccines, Amino Acid Sequence, Antibodies, Neutralizing, Antibodies, Viral, B-Lymphocytes, Crystallography, X-Ray, HIV Envelope Protein gp120, HIV Envelope Protein gp41, HIV-1, Humans, Hydrophobic and Hydrophilic Interactions, Immunodominant Epitopes, Molecular Sequence Data, Peptides, Protein Conformation, Viral Fusion Proteins, Virus Internalization
Added May 3, 2017
0 Communities
1 Members
0 Resources
17 MeSH Terms
Maturation-induced cloaking of neutralization epitopes on HIV-1 particles.
Joyner AS, Willis JR, Crowe JE, Aiken C
(2011) PLoS Pathog 7: e1002234
MeSH Terms: Antibodies, Monoclonal, Antibodies, Neutralizing, CD4-Positive T-Lymphocytes, Cell Line, Epitopes, Fluorescent Antibody Technique, Gene Expression Regulation, Viral, Genes, env, HIV Antibodies, HIV Envelope Protein gp120, HIV Envelope Protein gp41, HIV-1, Humans, Immune Evasion, Immunoblotting, Neutralization Tests, Virion
Added December 5, 2013
1 Communities
2 Members
0 Resources
17 MeSH Terms
Emerging studies of human HIV-specific antibody repertoires.
Hicar MD, Kalams SA, Spearman PW, Crowe JE
(2010) Vaccine 28 Suppl 2: B18-23
MeSH Terms: Antibodies, Neutralizing, Antibody Specificity, Antigenic Variation, B-Lymphocytes, HIV Antibodies, HIV Antigens, HIV Envelope Protein gp120, HIV Envelope Protein gp41, HIV Infections, Humans, Immunity, Humoral, env Gene Products, Human Immunodeficiency Virus
Added August 6, 2012
0 Communities
1 Members
0 Resources
12 MeSH Terms
Maturation-dependent human immunodeficiency virus type 1 particle fusion requires a carboxyl-terminal region of the gp41 cytoplasmic tail.
Jiang J, Aiken C
(2007) J Virol 81: 9999-10008
MeSH Terms: Gene Products, gag, HIV Envelope Protein gp41, HIV-1, Humans, Mutation, Protein Binding, Protein Structure, Tertiary, Virion, Virus Assembly, Virus Internalization
Added February 19, 2015
0 Communities
1 Members
0 Resources
10 MeSH Terms
A mutation in the human immunodeficiency virus type 1 Gag protein destabilizes the interaction of the envelope protein subunits gp120 and gp41.
Davis MR, Jiang J, Zhou J, Freed EO, Aiken C
(2006) J Virol 80: 2405-17
MeSH Terms: Amino Acid Motifs, Amino Acid Substitution, Cell Line, Gene Products, gag, HIV Envelope Protein gp120, HIV Envelope Protein gp41, HIV-1, Humans, Mutation, Protein Binding, Protein Structure, Tertiary, Sequence Deletion, Suppression, Genetic, T-Lymphocytes, Vesicular stomatitis Indiana virus, Virion, Virus Assembly, Virus Replication
Added February 19, 2015
0 Communities
1 Members
0 Resources
18 MeSH Terms
Maturation of the viral core enhances the fusion of HIV-1 particles with primary human T cells and monocyte-derived macrophages.
Jiang J, Aiken C
(2006) Virology 346: 460-8
MeSH Terms: CD4-Positive T-Lymphocytes, Cell Line, HIV Envelope Protein gp41, HIV-1, Humans, Macrophages, Membrane Fusion, Receptors, CCR5, Receptors, CXCR4, Receptors, HIV, Virus Replication
Added February 19, 2015
0 Communities
1 Members
0 Resources
11 MeSH Terms
Nef stimulates human immunodeficiency virus type 1 replication in primary T cells by enhancing virion-associated gp120 levels: coreceptor-dependent requirement for Nef in viral replication.
Lundquist CA, Zhou J, Aiken C
(2004) J Virol 78: 6287-96
MeSH Terms: CD4 Antigens, CD4-Positive T-Lymphocytes, Cells, Cultured, Down-Regulation, Gene Products, nef, HIV Envelope Protein gp120, HIV Envelope Protein gp41, HIV-1, Humans, Receptors, CXCR4, Virion, Virus Replication, nef Gene Products, Human Immunodeficiency Virus
Added February 19, 2015
0 Communities
1 Members
0 Resources
13 MeSH Terms
Evidence for a stable interaction of gp41 with Pr55(Gag) in immature human immunodeficiency virus type 1 particles.
Wyma DJ, Kotov A, Aiken C
(2000) J Virol 74: 9381-7
MeSH Terms: Detergents, Gene Products, env, Gene Products, gag, HIV Envelope Protein gp41, HIV-1, Humans, Phospholipids, Protein Precursors
Added February 19, 2015
0 Communities
1 Members
0 Resources
8 MeSH Terms