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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 367

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The E3 ubiquitin ligase component, Cereblon, is an evolutionarily conserved regulator of Wnt signaling.
Shen C, Nayak A, Neitzel LR, Adams AA, Silver-Isenstadt M, Sawyer LM, Benchabane H, Wang H, Bunnag N, Li B, Wynn DT, Yang F, Garcia-Contreras M, Williams CH, Dakshanamurthy S, Hong CC, Ayad NG, Capobianco AJ, Ahmed Y, Lee E, Robbins DJ
(2021) Nat Commun 12: 5263
MeSH Terms: Adaptor Proteins, Signal Transducing, Animals, Casein Kinase Ialpha, Drosophila Proteins, Drosophila melanogaster, Embryo, Nonmammalian, Evolution, Molecular, HEK293 Cells, Humans, Immunologic Factors, Lenalidomide, Mice, Organoids, Peptide Hydrolases, Ubiquitin-Protein Ligases, Ubiquitination, Wnt Signaling Pathway, Zebrafish, Zebrafish Proteins
Added September 11, 2021
0 Communities
1 Members
0 Resources
19 MeSH Terms
RYR2 Channel Inhibition Is the Principal Mechanism of Flecainide Action in CPVT.
Kryshtal DO, Blackwell DJ, Egly CL, Smith AN, Batiste SM, Johnston JN, Laver DR, Knollmann BC
(2021) Circ Res 128: 321-331
MeSH Terms: Action Potentials, Animals, Anti-Arrhythmia Agents, Calcium Channel Blockers, Calcium Signaling, Calsequestrin, Disease Models, Animal, Female, Flecainide, HEK293 Cells, Heart Rate, Humans, Male, Mice, Knockout, Myocytes, Cardiac, Phosphorylation, Ryanodine Receptor Calcium Release Channel, Sarcoplasmic Reticulum, Sheep, Domestic, Tachycardia, Ventricular, Voltage-Gated Sodium Channel Blockers
Added December 21, 2020
1 Communities
0 Members
0 Resources
21 MeSH Terms
TRESK and TREK-2 two-pore-domain potassium channel subunits form functional heterodimers in primary somatosensory neurons.
Lengyel M, Czirják G, Jacobson DA, Enyedi P
(2020) J Biol Chem 295: 12408-12425
MeSH Terms: Animals, HEK293 Cells, Humans, Ion Transport, Mice, Neurons, Potassium, Potassium Channels, Potassium Channels, Tandem Pore Domain, Protein Multimerization, Somatosensory Cortex, Xenopus laevis
Added June 14, 2021
0 Communities
1 Members
0 Resources
MeSH Terms
Single Quantum Dot Tracking Unravels Agonist Effects on the Dopamine Receptor Dynamics.
Kovtun O, Torres R, Ferguson RS, Josephs T, Rosenthal SJ
(2021) Biochemistry 60: 1031-1043
MeSH Terms: Dopamine Agonists, HEK293 Cells, Humans, Ligands, Molecular Imaging, Quantum Dots, Receptors, Dopamine D2
Added March 7, 2022
0 Communities
1 Members
0 Resources
MeSH Terms
Symmetrically substituted dichlorophenes inhibit -acyl-phosphatidylethanolamine phospholipase D.
Aggarwal G, Zarrow JE, Mashhadi Z, Flynn CR, Vinson P, Weaver CD, Davies SS
(2020) J Biol Chem 295: 7289-7300
MeSH Terms: Animals, Bacterial Proteins, Bithionol, Dichlorophen, Enzyme Inhibitors, HEK293 Cells, Hexachlorophene, Humans, Mice, Phospholipase D, Quinazolines, Streptomyces, Sulfonamides
Added August 18, 2020
0 Communities
1 Members
0 Resources
13 MeSH Terms
Ins1-Cre and Ins1-CreER Gene Replacement Alleles Are Susceptible To Silencing By DNA Hypermethylation.
Mosleh E, Ou K, Haemmerle MW, Tembo T, Yuhas A, Carboneau BA, Townsend SE, Bosma KJ, Gannon M, O'Brien RM, Stoffers DA, Golson ML
(2020) Endocrinology 161:
MeSH Terms: Alleles, Animals, Cells, Cultured, DNA Methylation, Female, Gene Silencing, HEK293 Cells, Humans, Insulin, Insulin-Secreting Cells, Integrases, Islets of Langerhans, Male, Mice, Mice, Inbred C57BL, Mice, Transgenic, Organ Specificity, Recombination, Genetic
Added May 12, 2020
1 Communities
0 Members
0 Resources
18 MeSH Terms
Probing biophysical sequence constraints within the transmembrane domains of rhodopsin by deep mutational scanning.
Penn WD, McKee AG, Kuntz CP, Woods H, Nash V, Gruenhagen TC, Roushar FJ, Chandak M, Hemmerich C, Rusch DB, Meiler J, Schlebach JP
(2020) Sci Adv 6: eaay7505
MeSH Terms: Cell Membrane, Gene Expression, HEK293 Cells, Humans, Hydrophobic and Hydrophilic Interactions, Lipid Bilayers, Models, Molecular, Mutation, Protein Domains, Protein Folding, Protein Structure, Secondary, Recombinant Proteins, Rhodopsin, Solubility, Thermodynamics
Added March 21, 2020
0 Communities
1 Members
0 Resources
15 MeSH Terms
Identification of a selective manganese ionophore that enables nonlethal quantification of cellular manganese.
Horning KJ, Joshi P, Nitin R, Balachandran RC, Yanko FM, Kim K, Christov P, Aschner M, Sulikowski GA, Weaver CD, Bowman AB
(2020) J Biol Chem 295: 3875-3890
MeSH Terms: Animals, Calcimycin, Calcium, Cell Line, Cell Survival, Fura-2, HEK293 Cells, Humans, Induced Pluripotent Stem Cells, Ionomycin, Ionophores, Male, Manganese, Mass Spectrometry, Mice
Added March 27, 2020
0 Communities
1 Members
0 Resources
15 MeSH Terms
Deep Mutational Scan of an Voltage Sensor.
Glazer AM, Kroncke BM, Matreyek KA, Yang T, Wada Y, Shields T, Salem JE, Fowler DM, Roden DM
(2020) Circ Genom Precis Med 13: e002786
MeSH Terms: Cardiotonic Agents, DNA Mutational Analysis, HEK293 Cells, Humans, Marine Toxins, Mutation, NAV1.5 Voltage-Gated Sodium Channel, Ouabain, Oxocins, Pharmacogenomic Testing, Veratridine
Added March 4, 2020
0 Communities
2 Members
0 Resources
11 MeSH Terms
The CK1α Activator Pyrvinium Enhances the Catalytic Efficiency (/) of CK1α.
Shen C, Li B, Astudillo L, Deutscher MP, Cobb MH, Capobianco AJ, Lee E, Robbins DJ
(2019) Biochemistry 58: 5102-5106
MeSH Terms: Biocatalysis, Casein Kinase Ialpha, Enzyme Activation, HEK293 Cells, Humans, Kinetics, Pyrvinium Compounds
Added December 22, 2019
0 Communities
1 Members
0 Resources
7 MeSH Terms