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Proteomics show antigen presentation processes in human immune cells after AS03-H5N1 vaccination.
Galassie AC, Goll JB, Samir P, Jensen TL, Hoek KL, Howard LM, Allos TM, Niu X, Gordy LE, Creech CB, Hill H, Joyce S, Edwards KM, Link AJ
(2017) Proteomics 17:
MeSH Terms: Adjuvants, Immunologic, Antigen Presentation, B-Lymphocytes, Cells, Cultured, Humans, Influenza A Virus, H5N1 Subtype, Influenza Vaccines, Influenza, Human, Killer Cells, Natural, Monocytes, Neutrophils, Protein Interaction Maps, Proteome, Proteomics, T-Lymphocytes
Added August 15, 2017
1 Communities
0 Members
0 Resources
15 MeSH Terms
Cell-Based Systems Biology Analysis of Human AS03-Adjuvanted H5N1 Avian Influenza Vaccine Responses: A Phase I Randomized Controlled Trial.
Howard LM, Hoek KL, Goll JB, Samir P, Galassie A, Allos TM, Niu X, Gordy LE, Creech CB, Prasad N, Jensen TL, Hill H, Levy SE, Joyce S, Link AJ, Edwards KM
(2017) PLoS One 12: e0167488
MeSH Terms: Adjuvants, Immunologic, Adolescent, Adult, Antibodies, Viral, Antibody Formation, Antigen Presentation, Chemokine CXCL10, Dendritic Cells, Double-Blind Method, Female, Hemagglutination Inhibition Tests, Humans, Influenza A Virus, H5N1 Subtype, Influenza Vaccines, Influenza, Human, Interleukin-6, Killer Cells, Natural, Male, Middle Aged, Monocytes, Neutrophils, Systems Biology, Vaccination, Young Adult
Added May 3, 2017
0 Communities
1 Members
0 Resources
24 MeSH Terms
Vaccine-Induced Antibodies that Neutralize Group 1 and Group 2 Influenza A Viruses.
Joyce MG, Wheatley AK, Thomas PV, Chuang GY, Soto C, Bailer RT, Druz A, Georgiev IS, Gillespie RA, Kanekiyo M, Kong WP, Leung K, Narpala SN, Prabhakaran MS, Yang ES, Zhang B, Zhang Y, Asokan M, Boyington JC, Bylund T, Darko S, Lees CR, Ransier A, Shen CH, Wang L, Whittle JR, Wu X, Yassine HM, Santos C, Matsuoka Y, Tsybovsky Y, Baxa U, NISC Comparative Sequencing Program, Mullikin JC, Subbarao K, Douek DC, Graham BS, Koup RA, Ledgerwood JE, Roederer M, Shapiro L, Kwong PD, Mascola JR, McDermott AB
(2016) Cell 166: 609-623
MeSH Terms: Adult, Amino Acid Sequence, Antibodies, Neutralizing, Antibodies, Viral, B-Lymphocytes, Epitopes, B-Lymphocyte, Female, Gene Rearrangement, B-Lymphocyte, Heavy Chain, Humans, Immunologic Memory, Influenza A Virus, H5N1 Subtype, Influenza A virus, Influenza Vaccines, Male, Middle Aged, Models, Molecular, Protein Structure, Tertiary, Structure-Activity Relationship, Young Adult
Added May 3, 2017
0 Communities
1 Members
0 Resources
19 MeSH Terms
Vaccine-elicited antibody that neutralizes H5N1 influenza and variants binds the receptor site and polymorphic sites.
Winarski KL, Thornburg NJ, Yu Y, Sapparapu G, Crowe JE, Spiller BW
(2015) Proc Natl Acad Sci U S A 112: 9346-51
MeSH Terms: Amino Acid Sequence, Antibodies, Monoclonal, Antibodies, Viral, Binding Sites, Crystallography, X-Ray, Genetic Variation, Hemagglutinin Glycoproteins, Influenza Virus, Humans, Immunoglobulin Fragments, Influenza A Virus, H5N1 Subtype, Influenza Vaccines, Influenza, Human, Molecular Conformation, Molecular Sequence Data, Mutation, N-Acetylneuraminic Acid, Protein Binding, Protein Structure, Tertiary, Sequence Homology, Amino Acid
Added January 26, 2016
0 Communities
2 Members
0 Resources
19 MeSH Terms
Influenza viruses with receptor-binding N1 neuraminidases occur sporadically in several lineages and show no attenuation in cell culture or mice.
Hooper KA, Crowe JE, Bloom JD
(2015) J Virol 89: 3737-45
MeSH Terms: Animals, Cell Line, Disease Models, Animal, Dogs, Female, Humans, Influenza A Virus, H1N1 Subtype, Influenza A Virus, H5N1 Subtype, Mice, Inbred BALB C, Mutant Proteins, Mutation, Missense, Neuraminidase, Orthomyxoviridae Infections, Protein Binding, Receptors, Virus, Reverse Genetics, Viral Proteins, Virus Attachment, Virus Cultivation
Added February 2, 2015
0 Communities
1 Members
0 Resources
19 MeSH Terms
Human antibodies that neutralize respiratory droplet transmissible H5N1 influenza viruses.
Thornburg NJ, Nannemann DP, Blum DL, Belser JA, Tumpey TM, Deshpande S, Fritz GA, Sapparapu G, Krause JC, Lee JH, Ward AB, Lee DE, Li S, Winarski KL, Spiller BW, Meiler J, Crowe JE
(2013) J Clin Invest 123: 4405-9
MeSH Terms: Amino Acid Sequence, Antibodies, Neutralizing, Antibodies, Viral, Binding Sites, Epitope Mapping, Humans, Hybridomas, Influenza A Virus, H5N1 Subtype, Influenza, Human, Leukocytes, Mononuclear, Models, Molecular, Molecular Sequence Data, Protein Binding, Protein Interaction Domains and Motifs, Vaccination
Added March 7, 2014
1 Communities
3 Members
0 Resources
15 MeSH Terms
A new determinant of H5N1 influenza virus pathogenesis in mammals.
Dermody TS, Sandri-Goldin RM, Shenk T
(2013) J Virol 87: 4795-6
MeSH Terms: Animals, Female, Hemagglutinin Glycoproteins, Influenza Virus, Influenza A Virus, H5N1 Subtype, Influenza in Birds, Virus Replication
Added May 20, 2014
0 Communities
1 Members
0 Resources
6 MeSH Terms
PB1-F2 proteins from H5N1 and 20 century pandemic influenza viruses cause immunopathology.
McAuley JL, Chipuk JE, Boyd KL, Van De Velde N, Green DR, McCullers JA
(2010) PLoS Pathog 6: e1001014
MeSH Terms: Animals, Birds, Disease Outbreaks, History, 20th Century, Humans, Immune System, Influenza A Virus, H5N1 Subtype, Influenza in Birds, Influenza, Human, Orthomyxoviridae, Viral Proteins
Added March 20, 2014
0 Communities
1 Members
0 Resources
11 MeSH Terms
Molecular changes in the polymerase genes (PA and PB1) associated with high pathogenicity of H5N1 influenza virus in mallard ducks.
Hulse-Post DJ, Franks J, Boyd K, Salomon R, Hoffmann E, Yen HL, Webby RJ, Walker D, Nguyen TD, Webster RG
(2007) J Virol 81: 8515-24
MeSH Terms: Amino Acid Substitution, Animals, DNA Mutational Analysis, Ducks, Ferrets, Genome, Viral, Hemagglutinin Glycoproteins, Influenza Virus, Influenza A Virus, H5N1 Subtype, Influenza in Birds, Mice, Mutation, RNA-Dependent RNA Polymerase, Viral Proteins, Virulence
Added March 5, 2014
0 Communities
1 Members
0 Resources
14 MeSH Terms