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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 39

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ERAAP and tapasin independently edit the amino and carboxyl termini of MHC class I peptides.
Kanaseki T, Lind KC, Escobar H, Nagarajan N, Reyes-Vargas E, Rudd B, Rockwood AL, Van Kaer L, Sato N, Delgado JC, Shastri N
(2013) J Immunol 191: 1547-55
MeSH Terms: Amino Acid Motifs, Amino Acid Sequence, Animals, Antigen Presentation, CD8-Positive T-Lymphocytes, Cells, Cultured, Consensus Sequence, Cytotoxicity, Immunologic, Endoplasmic Reticulum, Epitopes, T-Lymphocyte, Female, H-2 Antigens, Histocompatibility Antigen H-2D, Histocompatibility Antigens Class I, Leucyl Aminopeptidase, Membrane Transport Proteins, Mice, Mice, Inbred C57BL, Molecular Sequence Data, Peptide Fragments, Proteasome Endopeptidase Complex
Added March 7, 2014
0 Communities
1 Members
0 Resources
21 MeSH Terms
Tissue-specific regulation of CD8+ T-lymphocyte immunodominance in respiratory syncytial virus infection.
Lee S, Miller SA, Wright DW, Rock MT, Crowe JE
(2007) J Virol 81: 2349-58
MeSH Terms: Amino Acid Sequence, Animals, Antigens, Viral, CD8-Positive T-Lymphocytes, Female, H-2 Antigens, Humans, Immunodominant Epitopes, Interferon-gamma, Mice, Mice, Inbred BALB C, Respiratory Syncytial Virus Infections, Respiratory Syncytial Virus, Human, Viral Matrix Proteins
Added August 6, 2012
0 Communities
1 Members
0 Resources
14 MeSH Terms
Pivotal roles of CD8+ T cells restricted by MHC class I-like molecules in autoimmune diseases.
Das G, Das J, Eynott P, Zhang Y, Bothwell AL, Van Kaer L, Shi Y
(2006) J Exp Med 203: 2603-11
MeSH Terms: Animals, Autoimmune Diseases, CD8-Positive T-Lymphocytes, Cell Survival, Female, H-2 Antigens, Histocompatibility Antigen H-2D, Histocompatibility Antigens Class II, Inflammatory Bowel Diseases, Islets of Langerhans, Lymphoproliferative Disorders, Male, Mice, Mice, Inbred C57BL, Mice, Knockout, Mice, Transgenic, Nuclear Proteins, Trans-Activators, beta 2-Microglobulin
Added December 10, 2013
0 Communities
1 Members
0 Resources
19 MeSH Terms
In vivo role of ER-associated peptidase activity in tailoring peptides for presentation by MHC class Ia and class Ib molecules.
Yan J, Parekh VV, Mendez-Fernandez Y, Olivares-Villag├│mez D, Dragovic S, Hill T, Roopenian DC, Joyce S, Van Kaer L
(2006) J Exp Med 203: 647-59
MeSH Terms: Aminopeptidases, Animals, Antigen Presentation, CD8-Positive T-Lymphocytes, Gene Expression Regulation, H-2 Antigens, Histocompatibility Antigens Class I, Mice, Mice, Knockout, Minor Histocompatibility Antigens, Peptides
Added December 10, 2013
1 Communities
3 Members
0 Resources
11 MeSH Terms
Hepatocytes express abundant surface class I MHC and efficiently use transporter associated with antigen processing, tapasin, and low molecular weight polypeptide proteasome subunit components of antigen processing and presentation pathway.
Chen M, Tabaczewski P, Truscott SM, Van Kaer L, Stroynowski I
(2005) J Immunol 175: 1047-55
MeSH Terms: ATP Binding Cassette Transporter, Subfamily B, Member 2, ATP Binding Cassette Transporter, Subfamily B, Member 3, ATP-Binding Cassette Transporters, Animals, Antigen Presentation, Antiporters, Cell Membrane, Cells, Cultured, Cysteine Endopeptidases, Gene Expression Regulation, H-2 Antigens, Hepatocytes, Histocompatibility Antigen H-2D, Immunoglobulins, Listeriosis, Male, Membrane Transport Proteins, Mice, Mice, Inbred C57BL, Mice, Knockout, Multienzyme Complexes, Proteasome Endopeptidase Complex, Protein Processing, Post-Translational, Protein Subunits, Signal Transduction, Spleen
Added December 10, 2013
0 Communities
1 Members
0 Resources
26 MeSH Terms
Identification of an H-2D(b)-restricted CD8+ cytotoxic T lymphocyte epitope in the matrix protein of respiratory syncytial virus.
Rutigliano JA, Rock MT, Johnson AK, Crowe JE, Graham BS
(2005) Virology 337: 335-43
MeSH Terms: Amino Acid Sequence, Animals, Cell Line, Tumor, Cytokines, Disease Models, Animal, Epitopes, Female, H-2 Antigens, Histocompatibility Antigen H-2D, Humans, Major Histocompatibility Complex, Mice, Mice, Inbred BALB C, Molecular Sequence Data, Peptide Fragments, Respiratory Syncytial Virus Infections, Respiratory Syncytial Viruses, T-Lymphocytes, Cytotoxic, Viral Matrix Proteins
Added August 6, 2012
0 Communities
1 Members
0 Resources
19 MeSH Terms
Differential requirement for tapasin in the presentation of leader- and insulin-derived peptide antigens to Qa-1b-restricted CTLs.
Li L, Sullivan BA, Aldrich CJ, Soloski MJ, Forman J, Grandea AG, Jensen PE, Van Kaer L
(2004) J Immunol 173: 3707-15
MeSH Terms: Animals, Antigen Presentation, Antiporters, CD8-Positive T-Lymphocytes, Cell Differentiation, Cell Line, Cell Membrane, Clone Cells, Cytotoxicity, Immunologic, H-2 Antigens, Histocompatibility Antigens Class I, Immunoglobulins, Insulin, Membrane Transport Proteins, Mice, Mice, Inbred C3H, Mice, Inbred C57BL, Mice, Knockout, Mice, Transgenic, Peptide Fragments, Peptides, Protein Sorting Signals, Protein Transport, Receptors, Antigen, T-Cell, T-Lymphocytes, Cytotoxic
Added December 10, 2013
1 Communities
1 Members
0 Resources
25 MeSH Terms
Tapasin-/- and TAP1-/- macrophages are deficient in vacuolar alternate class I MHC (MHC-I) processing due to decreased MHC-I stability at phagolysosomal pH.
Chefalo PJ, Grandea AG, Van Kaer L, Harding CV
(2003) J Immunol 170: 5825-33
MeSH Terms: ATP Binding Cassette Transporter, Subfamily B, Member 2, ATP-Binding Cassette Transporters, Acids, Animals, Antigen Presentation, Antigens, Bacterial, Antiporters, Cell Membrane, Cells, Cultured, Egg Proteins, Golgi Apparatus, H-2 Antigens, Half-Life, Hot Temperature, Hydrogen-Ion Concentration, Immunoglobulins, Macrophages, Membrane Transport Proteins, Mice, Mice, Inbred C57BL, Mice, Knockout, Ovalbumin, Peptide Fragments, Phagosomes, Temperature, Vacuoles
Added December 10, 2013
1 Communities
1 Members
0 Resources
26 MeSH Terms
The H4b minor histocompatibility antigen is caused by a combination of genetically determined and posttranslational modifications.
Yadav R, Yoshimura Y, Boesteanu A, Christianson GJ, Ajayi WU, Shashidharamurthy R, Stanic AK, Roopenian DC, Joyce S
(2003) J Immunol 170: 5133-42
MeSH Terms: Amino Acid Substitution, Animals, Combinatorial Chemistry Techniques, Conserved Sequence, Epitopes, T-Lymphocyte, H-2 Antigens, Humans, Immunodominant Epitopes, Isoleucine, Membrane Glycoproteins, Membrane Proteins, Mice, Mice, Inbred BALB C, Mice, Inbred C57BL, Minor Histocompatibility Antigens, Minor Histocompatibility Loci, Molecular Mimicry, Oligopeptides, Peptide Library, Phosphopeptides, Protein Processing, Post-Translational, Threonine
Added May 19, 2014
0 Communities
1 Members
0 Resources
22 MeSH Terms
Rejection of grafts with no H-2 disparity in TAP1 mutant mice: CD4 T cells are important effector cells and self H-2b class I molecules are target.
Suárez IM, Benvenutti LA, Noronh I, Van Kaer L, Kalil J, Coelho V
(2002) Transpl Immunol 9: 101-10
MeSH Terms: ATP Binding Cassette Transporter, Subfamily B, Member 2, ATP-Binding Cassette Transporters, Amino Acid Sequence, Animals, CD4-Positive T-Lymphocytes, Cytokines, Graft Rejection, H-2 Antigens, Immunohistochemistry, Mice, Mice, Inbred C57BL, Mice, Knockout, Molecular Sequence Data, Skin Transplantation
Added December 10, 2013
0 Communities
1 Members
0 Resources
14 MeSH Terms