Allosteric Regulation of Oligomerization by a B Trafficking G-Protein Is Corrupted in Methylmalonic Aciduria.
Ruetz M, Campanello GC, McDevitt L, Yokom AL, Yadav PK, Watkins D, Rosenblatt DS, Ohi MD, Southworth DR, Banerjee R
(2019) Cell Chem Biol 26
: 960-969.e4MeSH Terms: Allosteric Regulation, Amino Acid Metabolism, Inborn Errors, Fibroblasts, Guanosine Triphosphate, Humans, Methylmalonyl-CoA Mutase, Molecular Chaperones, Mutation, Protein Transport, Vitamin B 12Added March 3, 2020
10 MeSH Terms
A Conserved Hydrophobic Core in Gαi1 Regulates G Protein Activation and Release from Activated Receptor.
Kaya AI, Lokits AD, Gilbert JA, Iverson TM, Meiler J, Hamm HE
(2016) J Biol Chem 291
: 19674-86MeSH Terms: Enzyme Activation, GTP-Binding Protein alpha Subunits, Gi-Go, Guanosine Diphosphate, Guanosine Triphosphate, Humans, Hydrophobic and Hydrophilic Interactions, Protein Structure, SecondaryAdded April 8, 2017
7 MeSH Terms
Linking receptor activation to changes in Sw I and II of Gα proteins.
Hamm HE, Kaya AI, Gilbert JA, Preininger AM
(2013) J Struct Biol 184
: 63-74MeSH Terms: Amino Acid Sequence, Animals, GTP-Binding Proteins, Guanosine Triphosphate, Molecular Sequence Data, Protein Binding, Rats, Receptors, G-Protein-CoupledAdded December 10, 2013
8 MeSH Terms
Interaction of a G protein with an activated receptor opens the interdomain interface in the alpha subunit.
Van Eps N, Preininger AM, Alexander N, Kaya AI, Meier S, Meiler J, Hamm HE, Hubbell WL
(2011) Proc Natl Acad Sci U S A 108
: 9420-4MeSH Terms: Amino Acid Sequence, Animals, Cell Membrane, Cross-Linking Reagents, Electron Spin Resonance Spectroscopy, GTP-Binding Protein alpha Subunits, GTP-Binding Proteins, Guanosine Diphosphate, Guanosine Triphosphate, Models, Molecular, Molecular Sequence Data, Mutation, Protein Binding, Protein Structure, Secondary, Protein Structure, Tertiary, Rats, Receptors, G-Protein-Coupled, Rhodopsin, Spin LabelsAdded January 24, 2015
19 MeSH Terms
Modulation of the structure, catalytic activity, and fidelity of African swine fever virus DNA polymerase X by a reversible disulfide switch.
Voehler MW, Eoff RL, McDonald WH, Guengerich FP, Stone MP
(2009) J Biol Chem 284
: 18434-44MeSH Terms: African Swine Fever Virus, Catalysis, DNA, Viral, DNA-Directed DNA Polymerase, Disulfides, Enzyme Activation, Guanosine Triphosphate, Kinetics, Nuclear Magnetic Resonance, Biomolecular, Oxidation-Reduction, Structure-Activity Relationship, Substrate Specificity, Virus ReplicationAdded March 20, 2014
13 MeSH Terms
RhoB plays an essential role in CXCR2 sorting decisions.
Neel NF, Lapierre LA, Goldenring JR, Richmond A
(2007) J Cell Sci 120
: 1559-71MeSH Terms: Actins, Bridged Bicyclo Compounds, Heterocyclic, Cell Line, Chemotaxis, Cycloheximide, Cytochalasin B, Endosomes, Guanosine Triphosphate, Humans, Interleukin-8, Lysosome-Associated Membrane Glycoproteins, Lysosomes, Models, Biological, Mutation, Protein Transport, RNA, Small Interfering, Receptor, IGF Type 2, Receptors, Interleukin-8B, Receptors, Transferrin, Thiazolidines, Transfection, rab GTP-Binding Proteins, rab4 GTP-Binding Proteins, rhoB GTP-Binding ProteinAdded May 30, 2013
24 MeSH Terms
Competition between lithium and magnesium ions for the G-protein transducin in the guanosine 5'-diphosphate bound conformation.
Srinivasan C, Toon J, Amari L, Abukhdeir AM, Hamm H, Geraldes CF, Ho YK, Mota de Freitas D
(2004) J Inorg Biochem 98
: 691-701MeSH Terms: Animals, Binding, Competitive, Bipolar Disorder, Cattle, Guanosine Diphosphate, Guanosine Triphosphate, Humans, In Vitro Techniques, Kinetics, Lithium, Magnesium, Magnetic Resonance Spectroscopy, Protein Conformation, Rod Cell Outer Segment, Spectrometry, Fluorescence, TransducinAdded December 10, 2013
16 MeSH Terms
EphA2 receptor tyrosine kinase regulates endothelial cell migration and vascular assembly through phosphoinositide 3-kinase-mediated Rac1 GTPase activation.
Brantley-Sieders DM, Caughron J, Hicks D, Pozzi A, Ruiz JC, Chen J
(2004) J Cell Sci 117
: 2037-49MeSH Terms: Adenoviridae, Animals, Cattle, Cell Movement, Cell Proliferation, Cells, Cultured, Endothelium, Vascular, Enzyme Activation, Ephrin-A1, Ephrin-A2, Gene Expression Regulation, Enzymologic, Genes, Dominant, Guanosine Triphosphate, Immunoblotting, Immunoprecipitation, Lung, Mice, Microcirculation, Models, Genetic, Mutation, Neovascularization, Pathologic, Phosphatidylinositol 3-Kinases, Plasmids, Receptor, EphA2, Recombination, Genetic, rac1 GTP-Binding ProteinAdded February 24, 2014
26 MeSH Terms
A compositional segmentation of the human mitochondrial genome is related to heterogeneities in the guanine mutation rate.
Samuels DC, Boys RJ, Henderson DA, Chinnery PF
(2003) Nucleic Acids Res 31
: 6043-52MeSH Terms: Algorithms, DNA, Mitochondrial, Gene Frequency, Genetic Heterogeneity, Genetic Variation, Guanosine Triphosphate, Humans, Mutation, Probability, Time FactorsAdded December 12, 2013
10 MeSH Terms
Nuclear transport: never-ending cycles of signals and receptors.
Barry DM, Wente SR
(2000) Essays Biochem 36
: 89-103MeSH Terms: Active Transport, Cell Nucleus, Animals, Cell Nucleus, Cytoplasm, GTP Phosphohydrolases, Guanosine Triphosphate, Humans, Receptors, Cytoplasmic and Nuclear, Signal TransductionAdded March 21, 2014
9 MeSH Terms