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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 48

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A transient interaction between the phosphate binding loop and switch I contributes to the allosteric network between receptor and nucleotide in Gαi1.
Thaker TM, Sarwar M, Preininger AM, Hamm HE, Iverson TM
(2014) J Biol Chem 289: 11331-11341
MeSH Terms: Allosteric Regulation, Amino Acid Substitution, Animals, Crystallography, X-Ray, GTP-Binding Protein alpha Subunits, Gi-Go, Guanosine 5'-O-(3-Thiotriphosphate), Guanosine Diphosphate, Mutation, Missense, Protein Structure, Secondary, Rats
Added March 24, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
Extracellular loop II modulates GTP sensitivity of the prostaglandin EP3 receptor.
Natarajan C, Hata AN, Hamm HE, Zent R, Breyer RM
(2013) Mol Pharmacol 83: 206-16
MeSH Terms: Animals, Dinoprostone, Guanosine 5'-O-(3-Thiotriphosphate), HEK293 Cells, Humans, Point Mutation, Protein Conformation, Rabbits, Radioligand Assay, Receptors, Prostaglandin E, EP3 Subtype, Signal Transduction
Added December 21, 2013
1 Communities
3 Members
0 Resources
11 MeSH Terms
Total synthesis and biological evaluation of phidianidines A and B uncovers unique pharmacological profiles at CNS targets.
Brogan JT, Stoops SL, Lindsley CW
(2012) ACS Chem Neurosci 3: 658-64
MeSH Terms: Animals, CHO Cells, Cell Proliferation, Cell Survival, Central Nervous System Agents, Chromatography, High Pressure Liquid, Cricetinae, Cricetulus, Dopamine Plasma Membrane Transport Proteins, Gastropoda, Guanosine 5'-O-(3-Thiotriphosphate), HEK293 Cells, Humans, Indicators and Reagents, Indole Alkaloids, Ligands, Oxadiazoles, Radioligand Assay, Receptors, Opioid, mu, Serotonin Plasma Membrane Transport Proteins, Structure-Activity Relationship
Added March 7, 2014
1 Communities
1 Members
0 Resources
21 MeSH Terms
Trp fluorescence reveals an activation-dependent cation-pi interaction in the Switch II region of Galphai proteins.
Hamm HE, Meier SM, Liao G, Preininger AM
(2009) Protein Sci 18: 2326-35
MeSH Terms: Arginine, GTP-Binding Protein alpha Subunits, Gi-Go, Guanosine 5'-O-(3-Thiotriphosphate), Guanosine Diphosphate, Kinetics, Models, Molecular, Myristic Acid, Protein Conformation, Protein Structure, Tertiary, Spectrometry, Fluorescence, Tryptophan
Added December 10, 2013
0 Communities
1 Members
0 Resources
11 MeSH Terms
Epitope-tagged receptor knock-in mice reveal that differential desensitization of alpha2-adrenergic responses is because of ligand-selective internalization.
Lu R, Li Y, Zhang Y, Chen Y, Shields AD, Winder DG, Angelotti T, Jiao K, Limbird LE, Zhou Y, Wang Q
(2009) J Biol Chem 284: 13233-43
MeSH Terms: Adrenergic alpha-Agonists, Animals, Blotting, Southern, Brain, Calcium, Cells, Cultured, Clonidine, Electrophysiology, Endocytosis, Fluorescent Antibody Technique, GTP-Binding Proteins, Guanfacine, Guanosine 5'-O-(3-Thiotriphosphate), Hemagglutinins, Humans, Immunoenzyme Techniques, Integrases, Kidney, Male, Mice, Mice, Inbred C57BL, Neurons, Norepinephrine, Phosphorylation, Protein Binding, Receptors, Adrenergic, alpha-2, Signal Transduction, Sympathetic Nervous System, Transfection
Added August 13, 2010
1 Communities
1 Members
0 Resources
29 MeSH Terms
Receptor-mediated changes at the myristoylated amino terminus of Galpha(il) proteins.
Preininger AM, Parello J, Meier SM, Liao G, Hamm HE
(2008) Biochemistry 47: 10281-93
MeSH Terms: Detergents, GTP-Binding Protein alpha Subunits, Guanosine 5'-O-(3-Thiotriphosphate), Guanosine Diphosphate, Models, Molecular, Myristic Acid, Protein Conformation, Reactive Oxygen Species, Receptors, G-Protein-Coupled, Solubility, Surface Properties, Tryptophan
Added December 10, 2013
0 Communities
1 Members
0 Resources
12 MeSH Terms
Electroconvulsive shock treatment differentially modulates cortical and subcortical endocannabinoid activity.
Hill MN, Barr AM, Ho WS, Carrier EJ, Gorzalka BB, Hillard CJ
(2007) J Neurochem 103: 47-56
MeSH Terms: Amidohydrolases, Amygdala, Animals, Arachidonic Acids, Binding Sites, Cannabinoid Receptor Modulators, Cerebral Cortex, Down-Regulation, Electroshock, Endocannabinoids, Enzyme Activation, Guanosine 5'-O-(3-Thiotriphosphate), Hippocampus, Hypothalamus, Male, Polyunsaturated Alkamides, Prefrontal Cortex, Rats, Rats, Sprague-Dawley, Receptor, Cannabinoid, CB1, Up-Regulation
Added March 26, 2019
0 Communities
1 Members
0 Resources
MeSH Terms
Mapping allosteric connections from the receptor to the nucleotide-binding pocket of heterotrimeric G proteins.
Oldham WM, Van Eps N, Preininger AM, Hubbell WL, Hamm HE
(2007) Proc Natl Acad Sci U S A 104: 7927-32
MeSH Terms: Allosteric Regulation, Binding Sites, Electron Spin Resonance Spectroscopy, GTP-Binding Protein alpha Subunits, Gi-Go, Guanosine 5'-O-(3-Thiotriphosphate), Guanosine Diphosphate, Models, Molecular, Protein Conformation, Rhodopsin
Added December 10, 2013
0 Communities
1 Members
0 Resources
9 MeSH Terms
Interaction of calmodulin with the serotonin 5-hydroxytryptamine2A receptor. A putative regulator of G protein coupling and receptor phosphorylation by protein kinase C.
Turner JH, Raymond JR
(2005) J Biol Chem 280: 30741-50
MeSH Terms: Amino Acid Sequence, Animals, Binding Sites, Calmodulin, Cattle, Dansyl Compounds, Fibroblasts, Guanosine 5'-O-(3-Thiotriphosphate), Heterotrimeric GTP-Binding Proteins, Humans, Mice, Molecular Sequence Data, NIH 3T3 Cells, Peptides, Protein Binding, Protein Conformation, Protein Kinase C, Rats, Receptor, Serotonin, 5-HT2A, Sequence Alignment, Serotonin
Added July 23, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
N-desmethylclozapine, an allosteric agonist at muscarinic 1 receptor, potentiates N-methyl-D-aspartate receptor activity.
Sur C, Mallorga PJ, Wittmann M, Jacobson MA, Pascarella D, Williams JB, Brandish PE, Pettibone DJ, Scolnick EM, Conn PJ
(2003) Proc Natl Acad Sci U S A 100: 13674-9
MeSH Terms: Allosteric Site, Animals, Brain, Cell Line, Clozapine, Cricetinae, DNA, Complementary, Dose-Response Relationship, Drug, Electrophysiology, Guanosine 5'-O-(3-Thiotriphosphate), Hippocampus, Humans, Inhibitory Concentration 50, Mutagenesis, Site-Directed, Neurons, Protein Binding, Rats, Receptor, Muscarinic M1, Receptors, N-Methyl-D-Aspartate, Time Factors
Added February 19, 2015
0 Communities
1 Members
0 Resources
20 MeSH Terms