Other search tools

About this data

The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

If you have any questions or comments, please contact us.

Results: 1 to 10 of 10

Publication Record

Connections

Effects of VU0410120, a novel GlyT1 inhibitor, on measures of sociability, cognition and stereotypic behaviors in a mouse model of autism.
Burket JA, Benson AD, Green TL, Rook JM, Lindsley CW, Conn PJ, Deutsch SI
(2015) Prog Neuropsychopharmacol Biol Psychiatry 61: 10-7
MeSH Terms: Analysis of Variance, Animals, Benzamides, Dose-Response Relationship, Drug, Glycine Plasma Membrane Transport Proteins, Male, Maze Learning, Memory, Short-Term, Mice, Mice, Inbred BALB C, Mice, Inbred ICR, Piperidines, Social Behavior, Spatial Learning, Stereotyped Behavior
Added February 18, 2016
0 Communities
2 Members
0 Resources
15 MeSH Terms
Novel GlyT1 inhibitor chemotypes by scaffold hopping. Part 2: development of a [3.3.0]-based series and other piperidine bioisosteres.
Sheffler DJ, Nedelcovych MT, Williams R, Turner SC, Duerk BB, Robbins MR, Jadhav SB, Niswender CM, Jones CK, Conn PJ, Daniels RN, Lindsley CW
(2014) Bioorg Med Chem Lett 24: 1062-6
MeSH Terms: Dose-Response Relationship, Drug, Glycine Plasma Membrane Transport Proteins, Humans, Molecular Structure, Piperidines, Structure-Activity Relationship, Sulfonamides
Added February 19, 2015
0 Communities
3 Members
0 Resources
7 MeSH Terms
Novel GlyT1 inhibitor chemotypes by scaffold hopping. Part 1: development of a potent and CNS penetrant [3.1.0]-based lead.
Jones CK, Sheffler DJ, Williams R, Jadhav SB, Felts AS, Morrison RD, Niswender CM, Daniels JS, Conn PJ, Lindsley CW
(2014) Bioorg Med Chem Lett 24: 1067-70
MeSH Terms: Bridged Bicyclo Compounds, Dose-Response Relationship, Drug, Glycine Plasma Membrane Transport Proteins, Humans, Molecular Structure, Piperidines, Structure-Activity Relationship
Added February 19, 2015
0 Communities
3 Members
0 Resources
7 MeSH Terms
Targeting glutamate synapses in schizophrenia.
Field JR, Walker AG, Conn PJ
(2011) Trends Mol Med 17: 689-98
MeSH Terms: Animals, Antipsychotic Agents, Excitatory Amino Acid Agonists, Glycine Plasma Membrane Transport Proteins, Humans, Ligands, Mice, Mice, Knockout, Muscarinic Agonists, Rats, Receptors, Metabotropic Glutamate, Receptors, Muscarinic, Receptors, N-Methyl-D-Aspartate, Schizophrenia, Synapses, Synaptic Transmission
Added February 19, 2015
0 Communities
1 Members
0 Resources
16 MeSH Terms
Design of potent GlyT1 inhibitors: in vitro and in vivo profiles.
Bridges TM, Williams R, Lindsley CW
(2008) Curr Opin Mol Ther 10: 591-601
MeSH Terms: Animals, Antipsychotic Agents, Drug Design, Glycine Plasma Membrane Transport Proteins, Humans, Models, Biological, Receptors, N-Methyl-D-Aspartate, Sarcosine
Added March 5, 2014
1 Communities
1 Members
0 Resources
8 MeSH Terms
Design, synthesis, and in vivo efficacy of glycine transporter-1 (GlyT1) inhibitors derived from a series of [4-phenyl-1-(propylsulfonyl)piperidin-4-yl]methyl benzamides.
Lindsley CW, Zhao Z, Leister WH, O'Brien J, Lemaire W, Williams DL, Chen TB, Chang RS, Burno M, Jacobson MA, Sur C, Kinney GG, Pettibone DJ, Tiller PR, Smith S, Tsou NN, Duggan ME, Conn PJ, Hartman GD
(2006) ChemMedChem 1: 807-11
MeSH Terms: Animals, Antipsychotic Agents, Benzamides, Drug Design, Glycine Plasma Membrane Transport Proteins, Mice, Mice, Inbred DBA, Rats, Schizophrenia, Structure-Activity Relationship, Sulfonamides
Added February 19, 2015
0 Communities
1 Members
0 Resources
11 MeSH Terms
Effects of typical and atypical antipsychotics on human glycine transporters.
Williams JB, Mallorga PJ, Conn PJ, Pettibone DJ, Sur C
(2004) Schizophr Res 71: 103-12
MeSH Terms: Amino Acid Transport Systems, Neutral, Animals, Antipsychotic Agents, Benzodiazepines, Brain, Chloride Channels, Choriocarcinoma, Clozapine, Female, Glycine, Glycine Plasma Membrane Transport Proteins, Haloperidol, Humans, Membrane Glycoproteins, Membrane Transport Modulators, Membrane Transport Proteins, Olanzapine, Rats, Receptors, N-Methyl-D-Aspartate, Risperidone, Schizophrenia, Sodium Channels, Synapses, Uterine Neoplasms
Added February 19, 2015
0 Communities
1 Members
0 Resources
24 MeSH Terms
Development of a scintillation proximity assay for analysis of Na+/Cl- -dependent neurotransmitter transporter activity.
Williams JB, Mallorga PJ, Lemaire W, Williams DL, Na S, Patel S, Conn PJ, Conn JP, Pettibone DJ, Austin C, Sur C
(2003) Anal Biochem 321: 31-7
MeSH Terms: Amino Acid Transport Systems, Neutral, Carbon Radioisotopes, Cell Count, Cell Line, Tumor, Chlorides, Dose-Response Relationship, Drug, Female, Gene Expression Regulation, Neoplastic, Glycine, Glycine Plasma Membrane Transport Proteins, Humans, Pregnancy, Scintillation Counting, Sodium, Taurine, Time Factors
Added February 19, 2015
0 Communities
1 Members
0 Resources
16 MeSH Terms
Pharmacology and expression analysis of glycine transporter GlyT1 with [3H]-(N-[3-(4'-fluorophenyl)-3-(4'phenylphenoxy)propyl])sarcosine.
Mallorga PJ, Williams JB, Jacobson M, Marques R, Chaudhary A, Conn PJ, Pettibone DJ, Sur C
(2003) Neuropharmacology 45: 585-93
MeSH Terms: Amino Acid Transport Systems, Neutral, Analysis of Variance, Animals, Binding, Competitive, Cell Line, Cell Membrane, Central Nervous System, Dose-Response Relationship, Drug, Glycine, Glycine Plasma Membrane Transport Proteins, Humans, Kinetics, Lithium Chloride, Radioligand Assay, Rats, Sarcosine, Sodium Acetate, Sodium Chloride, Time Factors, Tritium
Added February 19, 2015
0 Communities
1 Members
0 Resources
20 MeSH Terms
The glycine transporter type 1 inhibitor N-[3-(4'-fluorophenyl)-3-(4'-phenylphenoxy)propyl]sarcosine potentiates NMDA receptor-mediated responses in vivo and produces an antipsychotic profile in rodent behavior.
Kinney GG, Sur C, Burno M, Mallorga PJ, Williams JB, Figueroa DJ, Wittmann M, Lemaire W, Conn PJ
(2003) J Neurosci 23: 7586-91
MeSH Terms: Amino Acid Transport Systems, Neutral, Animals, Antipsychotic Agents, Behavior, Animal, Biological Transport, Cell Line, Glycine, Glycine Plasma Membrane Transport Proteins, Humans, Long-Term Potentiation, Male, Mice, Mice, Inbred C57BL, Mice, Inbred DBA, Neural Inhibition, Proto-Oncogene Proteins c-fos, Rats, Rats, Sprague-Dawley, Receptors, N-Methyl-D-Aspartate, Sarcosine
Added February 19, 2015
0 Communities
1 Members
0 Resources
20 MeSH Terms