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Dysregulated transmethylation leading to hepatocellular carcinoma compromises redox homeostasis and glucose formation.
Hughey CC, James FD, Wang Z, Goelzer M, Wasserman DH
(2019) Mol Metab 23: 1-13
MeSH Terms: Animals, Carcinoma, Hepatocellular, DNA Methylation, Fatty Liver, Gene Knockout Techniques, Gluconeogenesis, Glucose, Glycine N-Methyltransferase, Homeostasis, Liver, Liver Neoplasms, Male, Methionine, Mice, Mice, Knockout, NAD, Oxidation-Reduction
Added March 26, 2019
1 Communities
0 Members
0 Resources
17 MeSH Terms
Glycine -methyltransferase deletion in mice diverts carbon flux from gluconeogenesis to pathways that utilize excess methionine cycle intermediates.
Hughey CC, Trefts E, Bracy DP, James FD, Donahue EP, Wasserman DH
(2018) J Biol Chem 293: 11944-11954
MeSH Terms: Animals, Carbon, Citric Acid Cycle, Energy Metabolism, Fatty Liver, Gene Deletion, Gluconeogenesis, Glucose, Glycine N-Methyltransferase, Liver, Male, Metabolic Flux Analysis, Methionine, Mice, Mice, Knockout, S-Adenosylmethionine
Added March 26, 2019
1 Communities
0 Members
0 Resources
MeSH Terms
TRAIL-producing NK cells contribute to liver injury and related fibrogenesis in the context of GNMT deficiency.
Fernández-Álvarez S, Gutiérrez-de Juan V, Zubiete-Franco I, Barbier-Torres L, Lahoz A, Parés A, Luka Z, Wagner C, Lu SC, Mato JM, Martínez-Chantar ML, Beraza N
(2015) Lab Invest 95: 223-36
MeSH Terms: Amino Acid Metabolism, Inborn Errors, Animals, Bile Ducts, Blotting, Western, End Stage Liver Disease, Flow Cytometry, Glycine N-Methyltransferase, Humans, Immunohistochemistry, Killer Cells, Natural, Ligation, Mice, Mice, Knockout, Receptors, TNF-Related Apoptosis-Inducing Ligand, TNF-Related Apoptosis-Inducing Ligand
Added January 20, 2015
0 Communities
1 Members
0 Resources
15 MeSH Terms
S-Adenosylmethionine increases circulating very-low density lipoprotein clearance in non-alcoholic fatty liver disease.
Martínez-Uña M, Varela-Rey M, Mestre D, Fernández-Ares L, Fresnedo O, Fernandez-Ramos D, Gutiérrez-de Juan V, Martin-Guerrero I, García-Orad A, Luka Z, Wagner C, Lu SC, García-Monzón C, Finnell RH, Aurrekoetxea I, Buqué X, Martínez-Chantar ML, Mato JM, Aspichueta P
(2015) J Hepatol 62: 673-81
MeSH Terms: Adult, Aged, Aged, 80 and over, Animals, Diet, High-Fat, Disease Models, Animal, Female, Glycine N-Methyltransferase, Humans, Lipoproteins, VLDL, Liver, Male, Membrane Proteins, Mice, Mice, Knockout, Middle Aged, Models, Biological, Non-alcoholic Fatty Liver Disease, Perilipin-2, S-Adenosylmethionine, Triglycerides, Young Adult
Added January 20, 2015
0 Communities
1 Members
0 Resources
22 MeSH Terms
Glycine N-methyltransferase expression in the hippocampus and its role in neurogenesis and cognitive performance.
Carrasco M, Rabaneda LG, Murillo-Carretero M, Ortega-Martínez S, Martínez-Chantar ML, Woodhoo A, Luka Z, Wagner C, Lu SC, Mato JM, Micó JA, Castro C
(2014) Hippocampus 24: 840-52
MeSH Terms: Amino Acid Metabolism, Inborn Errors, Animals, Cognition, Cyclin E, Fibroblast Growth Factor 2, Gene Expression Regulation, Glycine N-Methyltransferase, Hippocampus, MAP Kinase Signaling System, Maze Learning, Memory Disorders, Methionine, Methionine Adenosyltransferase, Methylation, Mice, Mice, Inbred C57BL, Mice, Knockout, Nerve Tissue Proteins, Neurogenesis, Neuronal Plasticity, Rotarod Performance Test, S-Adenosylmethionine
Added January 20, 2015
0 Communities
1 Members
0 Resources
22 MeSH Terms
Excess S-adenosylmethionine reroutes phosphatidylethanolamine towards phosphatidylcholine and triglyceride synthesis.
Martínez-Uña M, Varela-Rey M, Cano A, Fernández-Ares L, Beraza N, Aurrekoetxea I, Martínez-Arranz I, García-Rodríguez JL, Buqué X, Mestre D, Luka Z, Wagner C, Alonso C, Finnell RH, Lu SC, Martínez-Chantar ML, Aspichueta P, Mato JM
(2013) Hepatology 58: 1296-305
MeSH Terms: Animals, Disease Models, Animal, Fatty Liver, Female, Glycine N-Methyltransferase, Homeostasis, Lipid Metabolism, Liver, Male, Membrane Proteins, Mice, Mice, Knockout, Perilipin-2, Phosphatidylcholines, Phosphatidylethanolamines, S-Adenosylmethionine, Triglycerides
Added January 20, 2015
0 Communities
1 Members
0 Resources
17 MeSH Terms
Hepatoma cells from mice deficient in glycine N-methyltransferase have increased RAS signaling and activation of liver kinase B1.
Martínez-López N, García-Rodríguez JL, Varela-Rey M, Gutiérrez V, Fernández-Ramos D, Beraza N, Aransay AM, Schlangen K, Lozano JJ, Aspichueta P, Luka Z, Wagner C, Evert M, Calvisi DF, Lu SC, Mato JM, Martínez-Chantar ML
(2012) Gastroenterology 143: 787-798.e13
MeSH Terms: AMP-Activated Protein Kinases, Animals, Apoptosis, Azacitidine, Calcium-Calmodulin-Dependent Protein Kinase Kinase, Carcinoma, Hepatocellular, Cell Line, Tumor, Cell Proliferation, Cell Transformation, Neoplastic, Cyclic AMP-Dependent Protein Kinases, DNA Methylation, Enzyme Activation, Enzyme Inhibitors, Glycine N-Methyltransferase, Guanine Nucleotide Exchange Factors, Humans, Liver Neoplasms, Mice, Mice, Inbred C57BL, Mice, Knockout, Mice, Nude, Mitogen-Activated Protein Kinase 1, Mitogen-Activated Protein Kinase Kinases, Phosphorylation, Protein Serine-Threonine Kinases, RNA Interference, Ribosomal Protein S6 Kinases, 90-kDa, Signal Transduction, Time Factors, Transfection, Tumor Burden, ras Guanine Nucleotide Exchange Factors, ras Proteins
Added January 20, 2015
0 Communities
1 Members
0 Resources
33 MeSH Terms
Inhibition of natural killer cells protects the liver against acute injury in the absence of glycine N-methyltransferase.
Gomez-Santos L, Luka Z, Wagner C, Fernandez-Alvarez S, Lu SC, Mato JM, Martinez-Chantar ML, Beraza N
(2012) Hepatology 56: 747-59
MeSH Terms: Acute Disease, Adoptive Transfer, Animals, Apoptosis, Chemical and Drug Induced Liver Injury, Concanavalin A, Disease Models, Animal, Fatty Liver, Glycine N-Methyltransferase, Killer Cells, Natural, Lipopolysaccharides, Lymphocyte Depletion, Male, Mice, Mice, Knockout, Mitogens, TNF-Related Apoptosis-Inducing Ligand
Added January 20, 2015
0 Communities
1 Members
0 Resources
17 MeSH Terms
Two patients with hepatic mtDNA depletion syndromes and marked elevations of S-adenosylmethionine and methionine.
Mudd SH, Wagner C, Luka Z, Stabler SP, Allen RH, Schroer R, Wood T, Wang J, Wong LJ
(2012) Mol Genet Metab 105: 228-36
MeSH Terms: Adolescent, Base Sequence, DNA, Mitochondrial, Exons, Female, Glycine N-Methyltransferase, Humans, Infant, Liver, Male, Membrane Proteins, Methionine, Mitochondrial Diseases, Mitochondrial Proteins, Molecular Sequence Data, Mutation, S-Adenosylmethionine, Sequence Deletion
Added January 20, 2015
0 Communities
1 Members
0 Resources
18 MeSH Terms
Differences in folate-protein interactions result in differing inhibition of native rat liver and recombinant glycine N-methyltransferase by 5-methyltetrahydrofolate.
Luka Z, Pakhomova S, Loukachevitch LV, Newcomer ME, Wagner C
(2012) Biochim Biophys Acta 1824: 286-91
MeSH Terms: Animals, Catalytic Domain, Crystallography, X-Ray, Enzyme Inhibitors, Glycine N-Methyltransferase, Hydrogen Bonding, Liver, Models, Molecular, Protein Binding, Rats, Recombinant Proteins, Tetrahydrofolates, Valine
Added January 20, 2015
0 Communities
1 Members
0 Resources
13 MeSH Terms