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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 62

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Cell-programmed nutrient partitioning in the tumour microenvironment.
Reinfeld BI, Madden MZ, Wolf MM, Chytil A, Bader JE, Patterson AR, Sugiura A, Cohen AS, Ali A, Do BT, Muir A, Lewis CA, Hongo RA, Young KL, Brown RE, Todd VM, Huffstater T, Abraham A, O'Neil RT, Wilson MH, Xin F, Tantawy MN, Merryman WD, Johnson RW, Williams CS, Mason EF, Mason FM, Beckermann KE, Vander Heiden MG, Manning HC, Rathmell JC, Rathmell WK
(2021) Nature 593: 282-288
MeSH Terms: Animals, Carcinoma, Renal Cell, Cell Line, Tumor, Female, Glucose, Glutamine, Humans, Lipid Metabolism, Male, Mechanistic Target of Rapamycin Complex 1, Mice, Myeloid Cells, Neoplasms, Nutrients, Tumor Microenvironment
Added April 20, 2021
0 Communities
2 Members
0 Resources
15 MeSH Terms
Targeting In Vivo Metabolic Vulnerabilities of Th2 and Th17 Cells Reduces Airway Inflammation.
Healey DCC, Cephus JY, Barone SM, Chowdhury NU, Dahunsi DO, Madden MZ, Ye X, Yu X, Olszewski K, Young K, Gerriets VA, Siska PJ, Dworski R, Hemler J, Locasale JW, Poyurovsky MV, Peebles RS, Irish JM, Newcomb DC, Rathmell JC
(2021) J Immunol 206: 1127-1139
MeSH Terms: Adult, Alternaria, Animals, Asthma, Biomarkers, Blood Glucose, Bronchoalveolar Lavage Fluid, Case-Control Studies, Cells, Cultured, Dexamethasone, Disease Models, Animal, Drug Synergism, Female, Glucose Transporter Type 1, Glutaminase, Glutamine, Healthy Volunteers, Humans, Immunosuppressive Agents, Lung, Male, Mice, Middle Aged, Primary Cell Culture, Pyroglyphidae, Th17 Cells, Th2 Cells, Young Adult
Added March 26, 2021
3 Communities
1 Members
0 Resources
28 MeSH Terms
Non-canonical roles for metabolic enzymes and intermediates in malignant progression and metastasis.
Williams D, Fingleton B
(2019) Clin Exp Metastasis 36: 211-224
MeSH Terms: ATP Citrate (pro-S)-Lyase, Disease Progression, Energy Metabolism, Fatty Acids, Glucose, Glucose-6-Phosphate Isomerase, Glutaminase, Glutamine, Humans, Isocitrate Dehydrogenase, Neoplasm Metastasis, Neoplasms
Added March 24, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
Glutamine-451 Confers Sensitivity to Oxidative Inhibition and Heme-Thiolate Sulfenylation of Cytochrome P450 4B1.
Albertolle ME, Song HD, Wilkey CJ, Segrest JP, Guengerich FP
(2019) Chem Res Toxicol 32: 484-492
MeSH Terms: Animals, Aryl Hydrocarbon Hydroxylases, Glutamine, Heme, Molecular Dynamics Simulation, Mutagenesis, Site-Directed, Oxidation-Reduction, Rabbits, Sulfenic Acids, Sulfhydryl Compounds
Added March 26, 2019
0 Communities
1 Members
0 Resources
10 MeSH Terms
Glutamate-oxaloacetate transaminase activity promotes palmitate lipotoxicity in rat hepatocytes by enhancing anaplerosis and citric acid cycle flux.
Egnatchik RA, Leamy AK, Sacco SA, Cheah YE, Shiota M, Young JD
(2019) J Biol Chem 294: 3081-3090
MeSH Terms: Animals, Aspartate Aminotransferases, Cell Death, Cell Line, Citric Acid Cycle, Extracellular Space, Glutamine, Hepatocytes, Ketoglutaric Acids, Male, Oxidative Stress, Oxygen, Palmitates, Rats, Rats, Sprague-Dawley
Added March 28, 2019
0 Communities
1 Members
0 Resources
15 MeSH Terms
xCT (SLC7A11)-mediated metabolic reprogramming promotes non-small cell lung cancer progression.
Ji X, Qian J, Rahman SMJ, Siska PJ, Zou Y, Harris BK, Hoeksema MD, Trenary IA, Heidi C, Eisenberg R, Rathmell JC, Young JD, Massion PP
(2018) Oncogene 37: 5007-5019
MeSH Terms: 3T3 Cells, A549 Cells, Amino Acid Transport System y+, Animals, Carcinoma, Non-Small-Cell Lung, Cell Line, Cell Line, Tumor, Cell Proliferation, Cell Survival, Cystine, Cytoplasm, Disease Progression, Female, Glutamine, Humans, Lung Neoplasms, Male, Mice, Middle Aged
Added March 28, 2019
0 Communities
1 Members
0 Resources
MeSH Terms
Pharmacological blockade of ASCT2-dependent glutamine transport leads to antitumor efficacy in preclinical models.
Schulte ML, Fu A, Zhao P, Li J, Geng L, Smith ST, Kondo J, Coffey RJ, Johnson MO, Rathmell JC, Sharick JT, Skala MC, Smith JA, Berlin J, Washington MK, Nickels ML, Manning HC
(2018) Nat Med 24: 194-202
MeSH Terms: Amino Acid Transport System ASC, Animals, Cell Line, Tumor, Cell Proliferation, Computer Simulation, Disease Models, Animal, Glutamine, HCT116 Cells, Humans, Mice, Minor Histocompatibility Antigens, Neoplasms, Oxidative Stress, Signal Transduction, Small Molecule Libraries
Added March 14, 2018
0 Communities
4 Members
0 Resources
15 MeSH Terms
The receptor tyrosine kinase EphA2 promotes glutamine metabolism in tumors by activating the transcriptional coactivators YAP and TAZ.
Edwards DN, Ngwa VM, Wang S, Shiuan E, Brantley-Sieders DM, Kim LC, Reynolds AB, Chen J
(2017) Sci Signal 10:
MeSH Terms: Adaptor Proteins, Signal Transducing, Amino Acid Transport System ASC, Animals, Biomarkers, Tumor, Breast Neoplasms, DNA-Binding Proteins, Disease Models, Animal, Ephrin-A2, Female, Glutaminase, Glutamine, Humans, Intracellular Signaling Peptides and Proteins, Mice, Mice, Knockout, Minor Histocompatibility Antigens, Muscle Proteins, Phosphoproteins, Trans-Activators, Transcription Factors, Tumor Cells, Cultured
Added April 2, 2019
0 Communities
1 Members
0 Resources
21 MeSH Terms
Interrupted Glucagon Signaling Reveals Hepatic α Cell Axis and Role for L-Glutamine in α Cell Proliferation.
Dean ED, Li M, Prasad N, Wisniewski SN, Von Deylen A, Spaeth J, Maddison L, Botros A, Sedgeman LR, Bozadjieva N, Ilkayeva O, Coldren A, Poffenberger G, Shostak A, Semich MC, Aamodt KI, Phillips N, Yan H, Bernal-Mizrachi E, Corbin JD, Vickers KC, Levy SE, Dai C, Newgard C, Gu W, Stein R, Chen W, Powers AC
(2017) Cell Metab 25: 1362-1373.e5
MeSH Terms: Amino Acid Transport Systems, Neutral, Animals, Cell Proliferation, Glucagon, Glutamine, Liver, Mice, Mice, Knockout, Signal Transduction, Zebrafish, Zebrafish Proteins
Added September 21, 2018
0 Communities
4 Members
0 Resources
MeSH Terms
Non-Invasive Glutamine PET Reflects Pharmacological Inhibition of BRAF In Vivo.
Schulte ML, Hight MR, Ayers GD, Liu Q, Shyr Y, Washington MK, Manning HC
(2017) Mol Imaging Biol 19: 421-428
MeSH Terms: Amino Acid Transport System ASC, Animals, Cell Line, Tumor, Colonic Neoplasms, Female, Glutamine, Humans, Liver Neoplasms, Mice, Nude, Minor Histocompatibility Antigens, Mutation, Positron-Emission Tomography, Protein Kinase Inhibitors, Proto-Oncogene Proteins B-raf, Xenograft Model Antitumor Assays
Added April 6, 2017
0 Communities
2 Members
0 Resources
15 MeSH Terms