Loss of NRF2 impairs gastric nitrergic stimulation and function.Mukhopadhyay S, Sekhar KR, Hale AB, Channon KM, Farrugia G, Freeman ML, Gangula PR
(2011)
Free Radic Biol Med 51: 619-25
MeSH Terms: Animals, Antioxidants, Biopterin, Chloramphenicol O-Acetyltransferase, Disease Models, Animal, Down-Regulation, Gastric Emptying, Gastric Mucosa, Gastroparesis, Glutamate-Cysteine Ligase, Humans, Mice, Mice, Knockout, Muscle Relaxation, NF-E2-Related Factor 2, Nitrergic Neurons, Stomach, Superoxide Dismutase, Superoxide Dismutase-1, Vasomotor SystemAdded March 13, 2014 0 Communities
1 Members
0 Resources
20 MeSH Terms
Ascorbic acid prevents oxidant-induced increases in endothelial permeability.May JM, Qu ZC
(2011)
Biofactors 37: 46-50
MeSH Terms: Antioxidants, Ascorbic Acid, Buthionine Sulfoximine, Cell Line, Endothelial Cells, Glutamate-Cysteine Ligase, Glutathione, Humans, Hydrogen Peroxide, Inulin, Oxidants, Permeability, Vitamin K 3Added December 5, 2013 1 Communities
0 Members
0 Resources
13 MeSH Terms
Changes in S-adenosylmethionine and GSH homeostasis during endotoxemia in mice.Ko K, Yang H, Noureddin M, Iglesia-Ara A, Xia M, Wagner C, Luka Z, Mato JM, Lu SC
(2008)
Lab Invest 88: 1121-9
MeSH Terms: Animals, Disease Models, Animal, Endotoxemia, Glutamate-Cysteine Ligase, Glutathione, Male, Methionine Adenosyltransferase, Mice, S-Adenosylmethionine, Up-RegulationAdded January 20, 2015 0 Communities
1 Members
0 Resources
10 MeSH Terms
Smad3-ATF3 signaling mediates TGF-beta suppression of genes encoding Phase II detoxifying proteins.Bakin AV, Stourman NV, Sekhar KR, Rinehart C, Yan X, Meredith MJ, Arteaga CL, Freeman ML
(2005)
Free Radic Biol Med 38: 375-87
MeSH Terms: Activating Transcription Factor 3, Animals, Catalase, Cell Line, DNA-Binding Proteins, Gene Expression Regulation, Glutamate-Cysteine Ligase, Glutathione, Glutathione Transferase, Humans, Inactivation, Metabolic, Mice, RNA, Messenger, Reactive Oxygen Species, Signal Transduction, Smad3 Protein, Trans-Activators, Transcription Factors, Transforming Growth Factor betaAdded March 5, 2014 0 Communities
1 Members
0 Resources
19 MeSH Terms
NADPH oxidase activity is essential for Keap1/Nrf2-mediated induction of GCLC in response to 2-indol-3-yl-methylenequinuclidin-3-ols.Sekhar KR, Crooks PA, Sonar VN, Friedman DB, Chan JY, Meredith MJ, Starnes JH, Kelton KR, Summar SR, Sasi S, Freeman ML
(2003)
Cancer Res 63: 5636-45
MeSH Terms: Animals, Anticarcinogenic Agents, Gene Expression Regulation, Enzymologic, Glutamate-Cysteine Ligase, Humans, Indoles, Intracellular Signaling Peptides and Proteins, Kelch-Like ECH-Associated Protein 1, Mice, NADPH Oxidases, Proteins, Quinuclidines, Structure-Activity Relationship, Tumor Cells, CulturedAdded March 5, 2014 0 Communities
1 Members
0 Resources
14 MeSH Terms
Redox-sensitive interaction between KIAA0132 and Nrf2 mediates indomethacin-induced expression of gamma-glutamylcysteine synthetase.Sekhar KR, Spitz DR, Harris S, Nguyen TT, Meredith MJ, Holt JT, Gius D, Marnett LJ, Summar ML, Freeman ML, Guis D
(2002)
Free Radic Biol Med 32: 650-62
MeSH Terms: Anti-Inflammatory Agents, Non-Steroidal, Blotting, Northern, Carcinoma, Hepatocellular, Carrier Proteins, Chloramphenicol O-Acetyltransferase, DNA-Binding Proteins, Fluorescent Antibody Technique, Indirect, Glutamate-Cysteine Ligase, Glutathione, Humans, Ibuprofen, Indomethacin, Leucine Zippers, Liver Neoplasms, MAP Kinase Kinase 1, Mitogen-Activated Protein Kinase Kinases, NF-E2-Related Factor 2, Oxidation-Reduction, Promoter Regions, Genetic, Protein Serine-Threonine Kinases, RNA, Messenger, Trans-Activators, Transfection, Tumor Cells, CulturedAdded March 5, 2014 0 Communities
2 Members
0 Resources
24 MeSH Terms
Inhibition of the 26S proteasome induces expression of GLCLC, the catalytic subunit for gamma-glutamylcysteine synthetase.Sekhar KR, Soltaninassab SR, Borrelli MJ, Xu ZQ, Meredith MJ, Domann FE, Freeman ML
(2000)
Biochem Biophys Res Commun 270: 311-7
MeSH Terms: Acetylcysteine, Azetidines, Cells, Cultured, DNA-Binding Proteins, Enzyme Induction, Glutamate-Cysteine Ligase, Glutathione, Liver, NF-E2-Related Factor 2, Neoplasm Proteins, Peptide Hydrolases, Proteasome Endopeptidase Complex, Protein Structure, Quaternary, Response Elements, Trans-ActivatorsAdded March 5, 2014 0 Communities
1 Members
0 Resources
15 MeSH Terms
Multi-faceted regulation of gamma-glutamylcysteine synthetase.Soltaninassab SR, Sekhar KR, Meredith MJ, Freeman ML
(2000)
J Cell Physiol 182: 163-70
MeSH Terms: Amino Acid Sequence, Animals, Cell Physiological Phenomena, Chromosome Mapping, Disease, Gene Expression Regulation, Glutamate-Cysteine Ligase, Glutathione, Humans, Isoenzymes, Molecular Sequence Data, Transcription, GeneticAdded March 5, 2014 0 Communities
1 Members
0 Resources
12 MeSH Terms
Autophosphorylation inhibits the activity of gamma-glutamylcysteine synthetase.Sekhar KR, Freeman ML
(1999)
J Enzyme Inhib 14: 323-30
MeSH Terms: Adenosine Triphosphatases, Animals, Gene Expression Regulation, Enzymologic, Glutamate-Cysteine Ligase, Glutamic Acid, Kidney, Phosphorylation, Protein Kinases, Rats, Rats, Sprague-DawleyAdded March 5, 2014 0 Communities
1 Members
0 Resources
10 MeSH Terms
Expression of Bcl-2 increases intracellular glutathione by inhibiting methionine-dependent GSH efflux.Meredith MJ, Cusick CL, Soltaninassab S, Sekhar KS, Lu S, Freeman ML
(1998)
Biochem Biophys Res Commun 248: 458-63
MeSH Terms: Culture Media, Cysteine, Dithiothreitol, Glutamate-Cysteine Ligase, Glutathione, HeLa Cells, Humans, Kinetics, Methionine, Proto-Oncogene Proteins c-bcl-2, Recombinant Proteins, TransfectionAdded March 5, 2014 0 Communities
1 Members
0 Resources
12 MeSH Terms