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Loss of NRF2 impairs gastric nitrergic stimulation and function.
Mukhopadhyay S, Sekhar KR, Hale AB, Channon KM, Farrugia G, Freeman ML, Gangula PR
(2011) Free Radic Biol Med 51: 619-25
MeSH Terms: Animals, Antioxidants, Biopterin, Chloramphenicol O-Acetyltransferase, Disease Models, Animal, Down-Regulation, Gastric Emptying, Gastric Mucosa, Gastroparesis, Glutamate-Cysteine Ligase, Humans, Mice, Mice, Knockout, Muscle Relaxation, NF-E2-Related Factor 2, Nitrergic Neurons, Stomach, Superoxide Dismutase, Superoxide Dismutase-1, Vasomotor System
Added March 13, 2014
0 Communities
1 Members
0 Resources
20 MeSH Terms
Ascorbic acid prevents oxidant-induced increases in endothelial permeability.
May JM, Qu ZC
(2011) Biofactors 37: 46-50
MeSH Terms: Antioxidants, Ascorbic Acid, Buthionine Sulfoximine, Cell Line, Endothelial Cells, Glutamate-Cysteine Ligase, Glutathione, Humans, Hydrogen Peroxide, Inulin, Oxidants, Permeability, Vitamin K 3
Added December 5, 2013
1 Communities
0 Members
0 Resources
13 MeSH Terms
Changes in S-adenosylmethionine and GSH homeostasis during endotoxemia in mice.
Ko K, Yang H, Noureddin M, Iglesia-Ara A, Xia M, Wagner C, Luka Z, Mato JM, Lu SC
(2008) Lab Invest 88: 1121-9
MeSH Terms: Animals, Disease Models, Animal, Endotoxemia, Glutamate-Cysteine Ligase, Glutathione, Male, Methionine Adenosyltransferase, Mice, S-Adenosylmethionine, Up-Regulation
Added January 20, 2015
0 Communities
1 Members
0 Resources
10 MeSH Terms
Smad3-ATF3 signaling mediates TGF-beta suppression of genes encoding Phase II detoxifying proteins.
Bakin AV, Stourman NV, Sekhar KR, Rinehart C, Yan X, Meredith MJ, Arteaga CL, Freeman ML
(2005) Free Radic Biol Med 38: 375-87
MeSH Terms: Activating Transcription Factor 3, Animals, Catalase, Cell Line, DNA-Binding Proteins, Gene Expression Regulation, Glutamate-Cysteine Ligase, Glutathione, Glutathione Transferase, Humans, Inactivation, Metabolic, Mice, RNA, Messenger, Reactive Oxygen Species, Signal Transduction, Smad3 Protein, Trans-Activators, Transcription Factors, Transforming Growth Factor beta
Added March 5, 2014
0 Communities
1 Members
0 Resources
19 MeSH Terms
NADPH oxidase activity is essential for Keap1/Nrf2-mediated induction of GCLC in response to 2-indol-3-yl-methylenequinuclidin-3-ols.
Sekhar KR, Crooks PA, Sonar VN, Friedman DB, Chan JY, Meredith MJ, Starnes JH, Kelton KR, Summar SR, Sasi S, Freeman ML
(2003) Cancer Res 63: 5636-45
MeSH Terms: Animals, Anticarcinogenic Agents, Gene Expression Regulation, Enzymologic, Glutamate-Cysteine Ligase, Humans, Indoles, Intracellular Signaling Peptides and Proteins, Kelch-Like ECH-Associated Protein 1, Mice, NADPH Oxidases, Proteins, Quinuclidines, Structure-Activity Relationship, Tumor Cells, Cultured
Added March 5, 2014
0 Communities
1 Members
0 Resources
14 MeSH Terms
Redox-sensitive interaction between KIAA0132 and Nrf2 mediates indomethacin-induced expression of gamma-glutamylcysteine synthetase.
Sekhar KR, Spitz DR, Harris S, Nguyen TT, Meredith MJ, Holt JT, Gius D, Marnett LJ, Summar ML, Freeman ML, Guis D
(2002) Free Radic Biol Med 32: 650-62
MeSH Terms: Anti-Inflammatory Agents, Non-Steroidal, Blotting, Northern, Carcinoma, Hepatocellular, Carrier Proteins, Chloramphenicol O-Acetyltransferase, DNA-Binding Proteins, Fluorescent Antibody Technique, Indirect, Glutamate-Cysteine Ligase, Glutathione, Humans, Ibuprofen, Indomethacin, Leucine Zippers, Liver Neoplasms, MAP Kinase Kinase 1, Mitogen-Activated Protein Kinase Kinases, NF-E2-Related Factor 2, Oxidation-Reduction, Promoter Regions, Genetic, Protein Serine-Threonine Kinases, RNA, Messenger, Trans-Activators, Transfection, Tumor Cells, Cultured
Added March 5, 2014
0 Communities
2 Members
0 Resources
24 MeSH Terms
Inhibition of the 26S proteasome induces expression of GLCLC, the catalytic subunit for gamma-glutamylcysteine synthetase.
Sekhar KR, Soltaninassab SR, Borrelli MJ, Xu ZQ, Meredith MJ, Domann FE, Freeman ML
(2000) Biochem Biophys Res Commun 270: 311-7
MeSH Terms: Acetylcysteine, Azetidines, Cells, Cultured, DNA-Binding Proteins, Enzyme Induction, Glutamate-Cysteine Ligase, Glutathione, Liver, NF-E2-Related Factor 2, Neoplasm Proteins, Peptide Hydrolases, Proteasome Endopeptidase Complex, Protein Structure, Quaternary, Response Elements, Trans-Activators
Added March 5, 2014
0 Communities
1 Members
0 Resources
15 MeSH Terms
Multi-faceted regulation of gamma-glutamylcysteine synthetase.
Soltaninassab SR, Sekhar KR, Meredith MJ, Freeman ML
(2000) J Cell Physiol 182: 163-70
MeSH Terms: Amino Acid Sequence, Animals, Cell Physiological Phenomena, Chromosome Mapping, Disease, Gene Expression Regulation, Glutamate-Cysteine Ligase, Glutathione, Humans, Isoenzymes, Molecular Sequence Data, Transcription, Genetic
Added March 5, 2014
0 Communities
1 Members
0 Resources
12 MeSH Terms
Autophosphorylation inhibits the activity of gamma-glutamylcysteine synthetase.
Sekhar KR, Freeman ML
(1999) J Enzyme Inhib 14: 323-30
MeSH Terms: Adenosine Triphosphatases, Animals, Gene Expression Regulation, Enzymologic, Glutamate-Cysteine Ligase, Glutamic Acid, Kidney, Phosphorylation, Protein Kinases, Rats, Rats, Sprague-Dawley
Added March 5, 2014
0 Communities
1 Members
0 Resources
10 MeSH Terms
Expression of Bcl-2 increases intracellular glutathione by inhibiting methionine-dependent GSH efflux.
Meredith MJ, Cusick CL, Soltaninassab S, Sekhar KS, Lu S, Freeman ML
(1998) Biochem Biophys Res Commun 248: 458-63
MeSH Terms: Culture Media, Cysteine, Dithiothreitol, Glutamate-Cysteine Ligase, Glutathione, HeLa Cells, Humans, Kinetics, Methionine, Proto-Oncogene Proteins c-bcl-2, Recombinant Proteins, Transfection
Added March 5, 2014
0 Communities
1 Members
0 Resources
12 MeSH Terms