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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 11

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Small Molecule Inhibitor Screen Reveals Calcium Channel Signaling as a Mechanistic Mediator of TcdB-Induced Necrosis.
Farrow MA, Chumber NM, Bloch SC, King M, Moton-Melancon K, Shupe J, Washington MK, Spiller BW, Lacy DB
(2020) ACS Chem Biol 15: 1212-1221
MeSH Terms: Actin Cytoskeleton, Animals, Anti-Infective Agents, Bacterial Toxins, Calcium Channel Blockers, Calcium Channels, Calcium Signaling, Clostridioides difficile, Cytokines, Dihydropyridines, Dose-Response Relationship, Drug, Drug Evaluation, Preclinical, Glucosyltransferases, Humans, Kinetics, Mice, NADPH Oxidases, Necrosis, Reactive Oxygen Species, Virulence Factors
Added March 24, 2020
0 Communities
2 Members
0 Resources
20 MeSH Terms
Functional defects in TcdB toxin uptake identify CSPG4 receptor-binding determinants.
Gupta P, Zhang Z, Sugiman-Marangos SN, Tam J, Raman S, Julien JP, Kroh HK, Lacy DB, Murgolo N, Bekkari K, Therien AG, Hernandez LD, Melnyk RA
(2017) J Biol Chem 292: 17290-17301
MeSH Terms: Animals, Antibodies, Monoclonal, Antibodies, Neutralizing, Bacterial Proteins, Bacterial Toxins, Broadly Neutralizing Antibodies, CHO Cells, Caco-2 Cells, Chlorocebus aethiops, Chondroitin Sulfate Proteoglycans, Clostridioides difficile, Cricetinae, Cricetulus, Glucosyltransferases, HEK293 Cells, Humans, Membrane Proteins, Protein Binding, Protein Domains
Added April 3, 2018
0 Communities
1 Members
0 Resources
19 MeSH Terms
Use of a neutralizing antibody helps identify structural features critical for binding of toxin TcdA to the host cell surface.
Kroh HK, Chandrasekaran R, Rosenthal K, Woods R, Jin X, Ohi MD, Nyborg AC, Rainey GJ, Warrener P, Spiller BW, Lacy DB
(2017) J Biol Chem 292: 14401-14412
MeSH Terms: Amino Acid Sequence, Anti-Bacterial Agents, Antibodies, Monoclonal, Humanized, Antibodies, Neutralizing, Bacterial Proteins, Bacterial Toxins, Binding Sites, Antibody, Caco-2 Cells, Clostridioides difficile, Conserved Sequence, Crystallography, X-Ray, Enterocytes, Enterotoxins, Epitope Mapping, Glucosyltransferases, Humans, Immunoglobulin Fab Fragments, Models, Molecular, Peptide Fragments, Protein Conformation, Protein Interaction Domains and Motifs, Recombinant Proteins, Repetitive Sequences, Amino Acid
Added March 15, 2018
0 Communities
3 Members
0 Resources
23 MeSH Terms
Clostridium difficile toxin glucosyltransferase domains in complex with a non-hydrolyzable UDP-glucose analogue.
Alvin JW, Lacy DB
(2017) J Struct Biol 198: 203-209
MeSH Terms: Apigenin, Bacterial Proteins, Bacterial Toxins, Binding Sites, Clostridioides difficile, Enterotoxins, Glucosyltransferases, Molecular Structure, Protein Binding, Uridine Diphosphate Glucose
Added April 3, 2018
0 Communities
1 Members
0 Resources
10 MeSH Terms
Clostridium difficile Toxins TcdA and TcdB Cause Colonic Tissue Damage by Distinct Mechanisms.
Chumbler NM, Farrow MA, Lapierre LA, Franklin JL, Lacy DB
(2016) Infect Immun 84: 2871-7
MeSH Terms: Analysis of Variance, Animals, Apoptosis, Bacterial Toxins, Cell Death, Cells, Cultured, Clostridioides difficile, Colon, Enterotoxins, Epithelial Cells, Glucosyltransferases, Mice
Added April 26, 2017
0 Communities
1 Members
0 Resources
12 MeSH Terms
A Structural Study of CESA1 Catalytic Domain of Arabidopsis Cellulose Synthesis Complex: Evidence for CESA Trimers.
Vandavasi VG, Putnam DK, Zhang Q, Petridis L, Heller WT, Nixon BT, Haigler CH, Kalluri U, Coates L, Langan P, Smith JC, Meiler J, O'Neill H
(2016) Plant Physiol 170: 123-35
MeSH Terms: Arabidopsis, Arabidopsis Proteins, Catalytic Domain, Cellulose, Escherichia coli, Glucosyltransferases, Microscopy, Electron, Transmission, Models, Molecular, Multiprotein Complexes, Protein Multimerization, Protein Structure, Secondary, Recombinant Proteins, Scattering, Small Angle, X-Ray Diffraction
Added February 5, 2016
1 Communities
2 Members
0 Resources
14 MeSH Terms
Structural determinants of Clostridium difficile toxin A glucosyltransferase activity.
Pruitt RN, Chumbler NM, Rutherford SA, Farrow MA, Friedman DB, Spiller B, Lacy DB
(2012) J Biol Chem 287: 8013-20
MeSH Terms: Bacterial Proteins, Bacterial Toxins, Clostridioides difficile, Enterotoxins, Enzyme Activation, Glucosyltransferases, Protein Structure, Tertiary, Uridine Diphosphate Glucose, rap GTP-Binding Proteins
Added May 7, 2013
0 Communities
3 Members
0 Resources
9 MeSH Terms
Structural organization of the functional domains of Clostridium difficile toxins A and B.
Pruitt RN, Chambers MG, Ng KK, Ohi MD, Lacy DB
(2010) Proc Natl Acad Sci U S A 107: 13467-72
MeSH Terms: Animals, Bacterial Proteins, Bacterial Toxins, Binding Sites, CHO Cells, Clostridioides difficile, Cricetinae, Cricetulus, Electrophoresis, Polyacrylamide Gel, Enterotoxins, Glucosyltransferases, Hydrogen-Ion Concentration, Mice, Mice, Inbred BALB C, Microscopy, Electron, Models, Molecular, Protein Conformation, Protein Structure, Tertiary
Added May 7, 2013
0 Communities
3 Members
0 Resources
18 MeSH Terms
The fringe molecules induce endocrine differentiation in embryonic endoderm by activating cMyt1/cMyt3.
Xu Y, Wang S, Zhang J, Zhao A, Stanger BZ, Gu G
(2006) Dev Biol 297: 340-9
MeSH Terms: Animals, Basic Helix-Loop-Helix Transcription Factors, Cell Differentiation, Chick Embryo, DNA-Binding Proteins, Endocrine System, Gene Expression Regulation, Developmental, Glucosyltransferases, Islets of Langerhans, Mice, Models, Biological, Nerve Tissue Proteins, Pancreas, Proteins, Receptors, Notch, Transcription Factors
Added February 3, 2014
1 Communities
1 Members
0 Resources
16 MeSH Terms
Defective presentation of the CD1d1-restricted natural Va14Ja18 NKT lymphocyte antigen caused by beta-D-glucosylceramide synthase deficiency.
Stanic AK, De Silva AD, Park JJ, Sriram V, Ichikawa S, Hirabyashi Y, Hayakawa K, Van Kaer L, Brutkiewicz RR, Joyce S
(2003) Proc Natl Acad Sci U S A 100: 1849-54
MeSH Terms: Animals, Antigens, CD1, Antigens, CD1d, Base Sequence, Cell Line, Chromatography, Thin Layer, DNA Primers, Enzyme-Linked Immunosorbent Assay, Glucosyltransferases, Hybridomas, Killer Cells, Natural, Mice, Mice, Knockout
Added December 10, 2013
0 Communities
2 Members
0 Resources
13 MeSH Terms