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Liver glycogen-induced enhancements in hypoglycemic counterregulation require neuroglucopenia.
Warner SO, Wadian AM, Smith M, Farmer B, Dai Y, Sheanon N, Edgerton DS, Winnick JJ
(2021) Am J Physiol Endocrinol Metab 320: E914-E924
MeSH Terms: Animals, Blood Glucose, Brain, Dogs, Female, Gluconeogenesis, Glucose, Glucose Clamp Technique, Glycogen, Hypoglycemia, Hypoglycemic Agents, Insulin, Lipid Metabolism, Liver, Liver Glycogen, Male
Added November 9, 2021
0 Communities
1 Members
0 Resources
MeSH Terms
Safety of surgical denervation of the common hepatic artery in insulin-resistant dogs.
Kraft G, Scott M, Allen E, Edgerton DS, Farmer B, Azamian BR, Cherrington AD
(2021) Physiol Rep 9: e14805
MeSH Terms: Animals, Denervation, Disease Models, Animal, Dogs, Glucose Clamp Technique, Glucose Intolerance, Hepatic Artery, Hyperglycemia, Insulin Resistance, Male
Added November 9, 2021
0 Communities
1 Members
0 Resources
10 MeSH Terms
Metabolic effects of skeletal muscle-specific deletion of beta-arrestin-1 and -2 in mice.
Meister J, Bone DBJ, Godlewski G, Liu Z, Lee RJ, Vishnivetskiy SA, Gurevich VV, Springer D, Kunos G, Wess J
(2019) PLoS Genet 15: e1008424
MeSH Terms: Animals, Diabetes Mellitus, Type 2, Diet, High-Fat, Disease Models, Animal, Glucose, Glucose Clamp Technique, Glycogen, Humans, Insulin, Insulin Resistance, Male, Mice, Mice, Knockout, Muscle, Skeletal, Obesity, Signal Transduction, beta-Arrestin 1, beta-Arrestin 2
Added March 18, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
Aerobic exercise training improves hepatic and muscle insulin sensitivity, but reduces splanchnic glucose uptake in obese humans with type 2 diabetes.
Gregory JM, Muldowney JA, Engelhardt BG, Tyree R, Marks-Shulman P, Silver HJ, Donahue EP, Edgerton DS, Winnick JJ
(2019) Nutr Diabetes 9: 25
MeSH Terms: Adult, Diabetes Mellitus, Type 2, Exercise, Female, Glucose, Glucose Clamp Technique, Glucose Tolerance Test, Humans, Insulin Resistance, Liver, Male, Middle Aged, Muscle, Skeletal, Obesity
Added September 3, 2019
0 Communities
2 Members
0 Resources
14 MeSH Terms
Sympathetic Denervation of the Common Hepatic Artery Lessens Glucose Intolerance in the Fat- and Fructose-Fed Dog.
Kraft G, Vrba A, Scott M, Allen E, Edgerton DS, Williams PE, Vafai SB, Azamian BR, Cherrington AD
(2019) Diabetes 68: 1143-1155
MeSH Terms: Animals, Diet, High-Fat, Dietary Sugars, Dogs, Fructose, Glucose Clamp Technique, Glucose Intolerance, Glucose Tolerance Test, Hepatic Artery, Liver, Male, Norepinephrine, Pancreas, Random Allocation, Sympathectomy, Upper Gastrointestinal Tract
Added November 9, 2021
0 Communities
1 Members
0 Resources
MeSH Terms
Targeting insulin to the liver corrects defects in glucose metabolism caused by peripheral insulin delivery.
Edgerton DS, Scott M, Farmer B, Williams PE, Madsen P, Kjeldsen T, Brand CL, Fledelius C, Nishimura E, Cherrington AD
(2019) JCI Insight 5:
MeSH Terms: Animals, Dogs, Glucose, Glucose Clamp Technique, Hindlimb, Hyperglycemia, Hyperinsulinism, Hypoglycemic Agents, Insulin, Liver, Muscle, Skeletal, Portal Vein, Veins
Added November 9, 2021
0 Communities
1 Members
0 Resources
MeSH Terms
Systemic bile acids induce insulin resistance in a TGR5-independent manner.
Syring KE, Cyphert TJ, Beck TC, Flynn CR, Mignemi NA, McGuinness OP
(2019) Am J Physiol Endocrinol Metab 316: E782-E793
MeSH Terms: Animals, Bile Acids and Salts, Cholagogues and Choleretics, Cholic Acids, Deoxycholic Acid, Gene Expression Profiling, Gluconeogenesis, Glucose Clamp Technique, Hep G2 Cells, Hepatocytes, Humans, Insulin Resistance, Liver, Mice, Mice, Knockout, Obesity, Primary Cell Culture, Receptors, G-Protein-Coupled, Taurocholic Acid
Added April 15, 2019
0 Communities
1 Members
0 Resources
19 MeSH Terms
Insulin resistance is a significant determinant of sarcopenia in advanced kidney disease.
Deger SM, Hewlett JR, Gamboa J, Ellis CD, Hung AM, Siew ED, Mamnungu C, Sha F, Bian A, Stewart TG, Abumrad NN, Ikizler TA
(2018) Am J Physiol Endocrinol Metab 315: E1108-E1120
MeSH Terms: Adult, Body Composition, Cross-Sectional Studies, Female, Glucose, Glucose Clamp Technique, Humans, Insulin, Insulin Resistance, Male, Middle Aged, Muscle, Skeletal, Phosphorylation, Renal Dialysis, Renal Insufficiency, Chronic, Sarcopenia
Added September 24, 2018
0 Communities
1 Members
0 Resources
16 MeSH Terms
Acute effects of insulin on circulating natriuretic peptide levels in humans.
Bachmann KN, Deger SM, Alsouqi A, Huang S, Xu M, Ferguson JF, Su YR, Niswender KD, Ikizler TA, Wang TJ
(2018) PLoS One 13: e0196869
MeSH Terms: Adult, Aged, Atrial Natriuretic Factor, Female, Glucose Clamp Technique, Humans, Insulin, Insulin Resistance, Male, Middle Aged, Natriuretic Peptide, Brain, Obesity, Peptide Fragments
Added April 2, 2019
0 Communities
1 Members
0 Resources
MeSH Terms
Insulin exits skeletal muscle capillaries by fluid-phase transport.
Williams IM, Valenzuela FA, Kahl SD, Ramkrishna D, Mezo AR, Young JD, Wells KS, Wasserman DH
(2018) J Clin Invest 128: 699-714
MeSH Terms: Animals, Antigens, CD, Biological Transport, Capillaries, Diabetes Mellitus, Glucose, Glucose Clamp Technique, Humans, Hyperinsulinism, Image Processing, Computer-Assisted, Insulin, Intravital Microscopy, Kinetics, Male, Mice, Mice, Inbred C57BL, Models, Theoretical, Muscle, Skeletal, Protein Binding, Receptor, Insulin, Rhodamines
Added March 14, 2018
1 Communities
1 Members
0 Resources
21 MeSH Terms