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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 23

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Role of Bile Acids and GLP-1 in Mediating the Metabolic Improvements of Bariatric Surgery.
Albaugh VL, Banan B, Antoun J, Xiong Y, Guo Y, Ping J, Alikhan M, Clements BA, Abumrad NN, Flynn CR
(2019) Gastroenterology 156: 1041-1051.e4
MeSH Terms: Anastomosis, Surgical, Animals, Anticholesteremic Agents, Bariatric Surgery, Bile Acids and Salts, Blood Glucose, Cholestyramine Resin, Diet, High-Fat, Gallbladder, Glucagon-Like Peptide 1, Glucagon-Like Peptide-1 Receptor, Glucose Tolerance Test, Ileum, Insulin Resistance, Intestines, Lymph, Male, Mice, Mice, Inbred C57BL, Mice, Knockout, Receptors, Cytoplasmic and Nuclear, Receptors, G-Protein-Coupled, Signal Transduction, Verrucomicrobia, Weight Loss
Added January 4, 2019
0 Communities
2 Members
0 Resources
25 MeSH Terms
Glucagon-like peptide 1 signaling inhibits allergen-induced lung IL-33 release and reduces group 2 innate lymphoid cell cytokine production in vivo.
Toki S, Goleniewska K, Reiss S, Zhang J, Bloodworth MH, Stier MT, Zhou W, Newcomb DC, Ware LB, Stanwood GD, Galli A, Boyd KL, Niswender KD, Peebles RS
(2018) J Allergy Clin Immunol 142: 1515-1528.e8
MeSH Terms: Allergens, Alternaria, Animals, Asthma, Cytokines, Dermatophagoides pteronyssinus, Eosinophilia, Female, Glucagon-Like Peptide 1, Glucagon-Like Peptide-1 Receptor, Immunity, Innate, Interleukin-33, Lung, Lymphocytes, Mice, Inbred BALB C, Mice, Transgenic, Mucus, Signal Transduction
Added April 10, 2018
0 Communities
1 Members
0 Resources
18 MeSH Terms
Age-dependent human β cell proliferation induced by glucagon-like peptide 1 and calcineurin signaling.
Dai C, Hang Y, Shostak A, Poffenberger G, Hart N, Prasad N, Phillips N, Levy SE, Greiner DL, Shultz LD, Bottino R, Kim SK, Powers AC
(2017) J Clin Invest 127: 3835-3844
MeSH Terms: Adult, Aging, Animals, Calcineurin, Cyclin A1, Exenatide, Female, Forkhead Box Protein M1, Glucagon-Like Peptide 1, Glucagon-Like Peptide-1 Receptor, Humans, Insulin, Insulin Secretion, Insulin-Secreting Cells, Male, Mice, Inbred NOD, Middle Aged, NFATC Transcription Factors, Peptides, Signal Transduction, Venoms
Added March 29, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
The glucagon-like peptide-1 receptor in the ventromedial hypothalamus reduces short-term food intake in male mice by regulating nutrient sensor activity.
Burmeister MA, Brown JD, Ayala JE, Stoffers DA, Sandoval DA, Seeley RJ, Ayala JE
(2017) Am J Physiol Endocrinol Metab 313: E651-E662
MeSH Terms: Acetyl-CoA Carboxylase, Adenylate Kinase, Animals, Body Composition, CHO Cells, Cricetulus, Dose-Response Relationship, Drug, Eating, Exenatide, Food, Glucagon-Like Peptide-1 Receptor, Glycolysis, Homeostasis, Male, Mice, Mice, Inbred C57BL, Peptides, Sensation, TOR Serine-Threonine Kinases, Venoms, Ventromedial Hypothalamic Nucleus
Added October 23, 2017
0 Communities
1 Members
0 Resources
21 MeSH Terms
Discovery of a Novel Series of Orally Bioavailable and CNS Penetrant Glucagon-like Peptide-1 Receptor (GLP-1R) Noncompetitive Antagonists Based on a 1,3-Disubstituted-7-aryl-5,5-bis(trifluoromethyl)-5,8-dihydropyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione Core.
Nance KD, Days EL, Weaver CD, Coldren A, Farmer TD, Cho HP, Niswender CM, Blobaum AL, Niswender KD, Lindsley CW
(2017) J Med Chem 60: 1611-1616
MeSH Terms: Administration, Oral, Animals, Blood Glucose, Cells, Cultured, Central Nervous System, Glucagon-Like Peptide-1 Receptor, Halogenation, Humans, Insulin, Islets of Langerhans, Male, Pyrimidines, Rats, Sprague-Dawley
Added April 6, 2017
0 Communities
3 Members
0 Resources
13 MeSH Terms
The Hypothalamic Glucagon-Like Peptide 1 Receptor Is Sufficient but Not Necessary for the Regulation of Energy Balance and Glucose Homeostasis in Mice.
Burmeister MA, Ayala JE, Smouse H, Landivar-Rocha A, Brown JD, Drucker DJ, Stoffers DA, Sandoval DA, Seeley RJ, Ayala JE
(2017) Diabetes 66: 372-384
MeSH Terms: Animals, Body Composition, Diet, High-Fat, Eating, Energy Metabolism, Exenatide, Gene Knockdown Techniques, Glucagon-Like Peptide 1, Glucagon-Like Peptide-1 Receptor, Glucose, Glucose Tolerance Test, Homeostasis, Hypothalamus, Incretins, Liraglutide, Male, Mice, Neurons, Paraventricular Hypothalamic Nucleus, Peptides, Pro-Opiomelanocortin, Venoms, Weight Gain
Added October 23, 2017
0 Communities
1 Members
0 Resources
23 MeSH Terms
Glucagon-like peptide 1 receptor activation regulates cocaine actions and dopamine homeostasis in the lateral septum by decreasing arachidonic acid levels.
Reddy IA, Pino JA, Weikop P, Osses N, Sørensen G, Bering T, Valle C, Bluett RJ, Erreger K, Wortwein G, Reyes JG, Graham D, Stanwood GD, Hackett TA, Patel S, Fink-Jensen A, Torres GE, Galli A
(2016) Transl Psychiatry 6: e809
MeSH Terms: Animals, Arachidonic Acid, Arachidonic Acids, Cocaine, Dopamine, Dopamine Plasma Membrane Transport Proteins, Dopamine Uptake Inhibitors, Endocannabinoids, Exenatide, Glucagon-Like Peptide-1 Receptor, Glycerides, Homeostasis, Incretins, Mice, Microdialysis, Peptides, Proto-Oncogene Proteins c-fos, Septal Nuclei, Venoms
Added April 6, 2017
0 Communities
2 Members
0 Resources
19 MeSH Terms
Sustained expression of GLP-1 receptor differentially modulates β-cell functions in diabetic and nondiabetic mice.
Kubo F, Miyatsuka T, Sasaki S, Takahara M, Yamamoto Y, Shimo N, Watada H, Kaneto H, Gannon M, Matsuoka TA, Shimomura I
(2016) Biochem Biophys Res Commun 471: 68-74
MeSH Terms: Aging, Animals, Cells, Cultured, Diabetes Mellitus, Gene Expression Regulation, Glucagon-Like Peptide-1 Receptor, Glucose, Insulin, Insulin Secretion, Insulin-Secreting Cells, Male, Mice, Mice, Inbred C57BL, Mice, Transgenic
Added February 16, 2016
1 Communities
1 Members
0 Resources
14 MeSH Terms
Discovery of (S)-2-cyclopentyl-N-((1-isopropylpyrrolidin2-yl)-9-methyl-1-oxo-2,9-dihydro-1H-pyrrido[3,4-b]indole-4-carboxamide (VU0453379): a novel, CNS penetrant glucagon-like peptide 1 receptor (GLP-1R) positive allosteric modulator (PAM).
Morris LC, Nance KD, Gentry PR, Days EL, Weaver CD, Niswender CM, Thompson AD, Jones CK, Locuson CW, Morrison RD, Daniels JS, Niswender KD, Lindsley CW
(2014) J Med Chem 57: 10192-7
MeSH Terms: Allosteric Regulation, Animals, Catalepsy, Central Nervous System Agents, Drug Synergism, Exenatide, Glucagon-Like Peptide 1, Glucagon-Like Peptide-1 Receptor, Haloperidol, High-Throughput Screening Assays, Indoles, Insulin, Insulin Secretion, Islets of Langerhans, Male, Mice, Inbred C57BL, Microsomes, Liver, Peptides, Pyrrolidines, Receptors, Glucagon, Structure-Activity Relationship, Venoms
Added February 16, 2015
0 Communities
4 Members
0 Resources
22 MeSH Terms
The protective roles of GLP-1R signaling in diabetic nephropathy: possible mechanism and therapeutic potential.
Fujita H, Morii T, Fujishima H, Sato T, Shimizu T, Hosoba M, Tsukiyama K, Narita T, Takahashi T, Drucker DJ, Seino Y, Yamada Y
(2014) Kidney Int 85: 579-89
MeSH Terms: Animals, Cyclic AMP, Cyclic AMP-Dependent Protein Kinases, Diabetic Nephropathies, Glucagon-Like Peptide 1, Glucagon-Like Peptide-1 Receptor, Kidney Glomerulus, Liraglutide, Male, Mice, Inbred C57BL, NADPH Oxidases, Nitric Oxide, Oxidative Stress, Receptors, Glucagon, Signal Transduction
Added March 7, 2014
0 Communities
1 Members
0 Resources
15 MeSH Terms