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Diabetes medication regimens and patient clinical characteristics in the national patient-centered clinical research network, PCORnet.
Bachmann KN, Roumie CL, Wiese AD, Grijalva CG, Buse JB, Bradford R, Zalimeni EO, Knoepp P, Dard S, Morris HL, Donahoo WT, Fanous N, Fonseca V, Katalenich B, Choi S, Louzao D, O'Brien E, Cook MM, Rothman RL, Chakkalakal RJ
(2020) Pharmacol Res Perspect 8: e00637
MeSH Terms: Adult, Aged, Comorbidity, Diabetes Mellitus, Type 2, Dipeptidyl-Peptidase IV Inhibitors, Drug Therapy, Combination, Electronic Health Records, Female, Glucagon-Like Peptide-1 Receptor, Humans, Hyperlipidemias, Hypertension, Hypoglycemic Agents, Insulin, Male, Metformin, Middle Aged, Patient-Centered Care, Retrospective Studies, Sodium-Glucose Transporter 2 Inhibitors, Sulfonylurea Compounds, Thiazolidinediones, United States
Added March 29, 2022
0 Communities
1 Members
0 Resources
MeSH Terms
Tetraspanin-7 regulation of L-type voltage-dependent calcium channels controls pancreatic β-cell insulin secretion.
Dickerson MT, Dadi PK, Butterworth RB, Nakhe AY, Graff SM, Zaborska KE, Schaub CM, Jacobson DA
(2020) J Physiol 598: 4887-4905
MeSH Terms: Animals, Calcium, Calcium Channels, L-Type, Glucagon-Secreting Cells, Glucose, Insulin, Insulin Secretion, Insulin-Secreting Cells, Mice
Added June 14, 2021
0 Communities
1 Members
0 Resources
MeSH Terms
Lactate activation of α-cell K channels inhibits glucagon secretion by hyperpolarizing the membrane potential and reducing Ca entry.
Zaborska KE, Dadi PK, Dickerson MT, Nakhe AY, Thorson AS, Schaub CM, Graff SM, Stanley JE, Kondapavuluru RS, Denton JS, Jacobson DA
(2020) Mol Metab 42: 101056
MeSH Terms: Animals, Calcium, Cell Line, Cell Membrane, Glucagon, Glucagon-Secreting Cells, Glucose, Humans, Islets of Langerhans, KATP Channels, Lactic Acid, Male, Membrane Potentials, Mice, Mice, Inbred C57BL, Mice, Transgenic, Pancreas, Primary Cell Culture, Pyruvic Acid
Added June 14, 2021
0 Communities
1 Members
0 Resources
19 MeSH Terms
Dapagliflozin Does Not Directly Affect Human α or β Cells.
Dai C, Walker JT, Shostak A, Bouchi Y, Poffenberger G, Hart NJ, Jacobson DA, Calcutt MW, Bottino R, Greiner DL, Shultz LD, McGuinness OP, Dean ED, Powers AC
(2020) Endocrinology 161:
MeSH Terms: Adolescent, Adult, Animals, Benzhydryl Compounds, Cells, Cultured, Female, Glucagon, Glucagon-Secreting Cells, Glucosides, Heterografts, Humans, Insulin, Insulin Secretion, Insulin-Secreting Cells, Islets of Langerhans, Male, Mice, Mice, Inbred NOD, Mice, Transgenic, Middle Aged, Signal Transduction, Species Specificity, Young Adult
Added June 14, 2021
0 Communities
1 Members
0 Resources
MeSH Terms
The kinetics of glucagon action on the liver during insulin-induced hypoglycemia.
Pedersen C, Kraft G, Edgerton DS, Scott M, Farmer B, Smith M, Laneve DC, Williams PE, Moore LM, Cherrington AD
(2020) Am J Physiol Endocrinol Metab 318: E779-E790
MeSH Terms: Adrenalectomy, Animals, Dogs, Epinephrine, Female, Glucagon, Gluconeogenesis, Hydrocortisone, Hypoglycemia, Insulin, Liver, Male, Somatostatin, Sympathetic Nervous System
Added November 9, 2021
0 Communities
1 Members
0 Resources
MeSH Terms
A novel mouse model of glucagon-like peptide-1 receptor expression: A look at the brain.
Graham DL, Durai HH, Trammell TS, Noble BL, Mortlock DP, Galli A, Stanwood GD
(2020) J Comp Neurol 528: 2445-2470
MeSH Terms: Animals, Brain, Glucagon-Like Peptide 1, Mice, Mice, Transgenic, Models, Animal, Neurons, Transcriptome
Added September 15, 2020
1 Communities
0 Members
0 Resources
8 MeSH Terms
Global Transcriptomic Analysis of Zebrafish Glucagon Receptor Mutant Reveals Its Regulated Metabolic Network.
Kang Q, Hu M, Jia J, Bai X, Liu C, Wu Z, Chen W, Li M
(2020) Int J Mol Sci 21:
MeSH Terms: Animals, Gene Expression Profiling, Glucose, Liver, Metabolic Networks and Pathways, Receptors, Glucagon, Signal Transduction, Transcriptome, Zebrafish
Added September 14, 2021
0 Communities
1 Members
0 Resources
MeSH Terms
Lipid Droplet Accumulation in Human Pancreatic Islets Is Dependent On Both Donor Age and Health.
Tong X, Dai C, Walker JT, Nair GG, Kennedy A, Carr RM, Hebrok M, Powers AC, Stein R
(2020) Diabetes 69: 342-354
MeSH Terms: Acinar Cells, Adolescent, Adult, Age Factors, Aged, Animals, Child, Child, Preschool, Diabetes Mellitus, Experimental, Diabetes Mellitus, Type 2, Embryonic Stem Cells, Female, Glucagon-Secreting Cells, Humans, Infant, Insulin-Secreting Cells, Islets of Langerhans, Islets of Langerhans Transplantation, Lipid Droplets, Male, Mice, Microscopy, Electron, Microscopy, Fluorescence, Middle Aged, Rats, Tissue Donors, Young Adult
Added March 29, 2020
0 Communities
1 Members
0 Resources
27 MeSH Terms
Roux-en-Y gastric bypass surgery improves hepatic glucose metabolism and reduces plasma kisspeptin levels in morbidly obese patients with type 2 diabetes.
Flynn CR, Albaugh VL, Tamboli RA, Gregory JM, Bosompem A, Sidani RM, Winnick JJ
(2020) Am J Physiol Gastrointest Liver Physiol 318: G370-G374
MeSH Terms: Adolescent, Adult, Anastomosis, Roux-en-Y, Blood Glucose, Diabetes Mellitus, Type 2, Female, Glucagon, Glucose, Humans, Insulin, Kisspeptins, Liver, Male, Middle Aged, Obesity, Morbid, Treatment Outcome, Young Adult
Added November 12, 2019
0 Communities
2 Members
0 Resources
17 MeSH Terms
Effect of portal glucose sensing on incretin hormone secretion in a canine model.
Edgerton DS, Kraft G, Smith MS, Moore LM, Farmer B, Scott M, Moore MC, Nauck MA, Cherrington AD
(2019) Am J Physiol Endocrinol Metab 317: E244-E249
MeSH Terms: Animals, Blood Glucose, C-Peptide, Dogs, Female, Gastric Inhibitory Polypeptide, Glucagon-Like Peptide 1, Glucose, Glucose Tolerance Test, Hindlimb, Incretins, Infusions, Intravenous, Insulin, Male, Portal Vein, Regional Blood Flow, Veins
Added November 9, 2021
0 Communities
1 Members
0 Resources
MeSH Terms