Over-Generalizing About GC (Hypoxia): Pitfalls of Limiting Breadth of Experimental Systems and Analyses in Framing Informatics Conclusions.
Boothby MR, Raybuck A, Cho SH, Stengel KR, Haase VH, Hiebert S, Li J
(2021) Front Immunol 12
: 664249MeSH Terms: Animals, B-Lymphocytes, Biomarkers, Computational Biology, Energy Metabolism, Gene Expression Profiling, Gene Expression Regulation, Germinal Center, Humans, Hypoxia, Immunomodulation, Mice, TransgenicAdded May 28, 2021
12 MeSH Terms
Mass cytometry defines distinct immune profile in germinal center B-cell lymphomas.
Roussel M, Lhomme F, Roe CE, Bartkowiak T, Gravelle P, Laurent C, Fest T, Irish JM
(2020) Cancer Immunol Immunother 69
: 407-420MeSH Terms: Adult, Aged, Female, Flow Cytometry, Germinal Center, Humans, Lymphoma, Large B-Cell, Diffuse, Macrophages, Male, Middle Aged, Young AdultAdded January 14, 2020
11 MeSH Terms
Hypoxia-inducible factors in CD4 T cells promote metabolism, switch cytokine secretion, and T cell help in humoral immunity.
Cho SH, Raybuck AL, Blagih J, Kemboi E, Haase VH, Jones RG, Boothby MR
(2019) Proc Natl Acad Sci U S A 116
: 8975-8984MeSH Terms: Animals, Antibody Formation, B-Lymphocytes, Basic Helix-Loop-Helix Transcription Factors, CD4-Positive T-Lymphocytes, Cell Hypoxia, Cytokines, Germinal Center, Humans, Hypoxia, Hypoxia-Inducible Factor 1, alpha Subunit, Immunity, Humoral, Immunization, Lymphocyte Activation, Mice, Mice, Inbred C57BL, Mice, Transgenic, Receptors, CXCR5, Sheep, T-Lymphocytes, Helper-InducerAdded April 23, 2019
20 MeSH Terms
Human Germinal Center B Cells Differ from Naïve and Memory B Cells in CD40 Expression and CD40L-Induced Signaling Response.
Huse K, Wogsland CE, Polikowsky HG, Diggins KE, Smeland EB, Myklebust JH, Irish JM
(2019) Cytometry A 95
: 442-449MeSH Terms: B-Lymphocytes, CD40 Antigens, CD40 Ligand, Cells, Cultured, Germinal Center, Humans, Immunologic Memory, NF-kappa B, Phosphorylation, Signal TransductionAdded March 8, 2019
10 MeSH Terms
B Cell-Intrinsic mTORC1 Promotes Germinal Center-Defining Transcription Factor Gene Expression, Somatic Hypermutation, and Memory B Cell Generation in Humoral Immunity.
Raybuck AL, Cho SH, Li J, Rogers MC, Lee K, Williams CL, Shlomchik M, Thomas JW, Chen J, Williams JV, Boothby MR
(2018) J Immunol 200
: 2627-2639MeSH Terms: Animals, B-Lymphocytes, Cell Differentiation, Gene Expression, Germinal Center, Immunity, Humoral, Immunoglobulin G, Immunologic Memory, Lymphocyte Activation, Mechanistic Target of Rapamycin Complex 1, Mice, Mice, Inbred C57BL, Mutation, Plasma Cells, Proto-Oncogene Proteins c-bcl-6, Signal Transduction, Transcription FactorsAdded March 14, 2018
17 MeSH Terms
Regulatory myeloid cells: an underexplored continent in B-cell lymphomas.
Roussel M, Irish JM, Menard C, Lhomme F, Tarte K, Fest T
(2017) Cancer Immunol Immunother 66
: 1103-1111MeSH Terms: Animals, Carcinogenesis, Gene Expression Regulation, Neoplastic, Germinal Center, Humans, Immunomodulation, Lymphoma, B-Cell, Myeloid-Derived Suppressor Cells, Tumor Escape, Tumor MicroenvironmentAdded August 19, 2017
10 MeSH Terms
Mass Cytometry of Follicular Lymphoma Tumors Reveals Intrinsic Heterogeneity in Proteins Including HLA-DR and a Deficit in Nonmalignant Plasmablast and Germinal Center B-Cell Populations.
Wogsland CE, Greenplate AR, Kolstad A, Myklebust JH, Irish JM, Huse K
(2017) Cytometry B Clin Cytom 92
: 79-87MeSH Terms: B-Lymphocytes, Flow Cytometry, Germinal Center, HLA-DR Antigens, Humans, Immunophenotyping, Lymphoma, B-Cell, Lymphoma, Follicular, Plasma Cells, T-Lymphocyte SubsetsAdded December 10, 2016
10 MeSH Terms
Germinal centre hypoxia and regulation of antibody qualities by a hypoxia response system.
Cho SH, Raybuck AL, Stengel K, Wei M, Beck TC, Volanakis E, Thomas JW, Hiebert S, Haase VH, Boothby MR
(2016) Nature 537
: 234-238MeSH Terms: Animals, Antibodies, B-Lymphocytes, Cell Hypoxia, Cell Proliferation, Cell Survival, Cytosine Deaminase, Germinal Center, Hypoxia, Immunoglobulin Class Switching, Mechanistic Target of Rapamycin Complex 1, Mice, Mice, Inbred C57BL, Multiprotein Complexes, TOR Serine-Threonine KinasesAdded August 9, 2016
15 MeSH Terms
Class-switched anti-insulin antibodies originate from unconventional antigen presentation in multiple lymphoid sites.
Wan X, Thomas JW, Unanue ER
(2016) J Exp Med 213
: 967-78MeSH Terms: Animals, Antigen Presentation, B-Lymphocytes, CD40 Antigens, Diabetes Mellitus, Type 1, Germinal Center, Immunoglobulin Class Switching, Insulin, Interleukin-4, Islets of Langerhans, Mice, Mice, Knockout, T-LymphocytesAdded November 23, 2016
13 MeSH Terms
Cutting Edge: Redox Signaling Hypersensitivity Distinguishes Human Germinal Center B Cells.
Polikowsky HG, Wogsland CE, Diggins KE, Huse K, Irish JM
(2015) J Immunol 195
: 1364-1367MeSH Terms: B-Lymphocyte Subsets, B-Lymphocytes, Cell Differentiation, Gene Expression, Germinal Center, Humans, Hydrogen Peroxide, Immunophenotyping, Oxidation-Reduction, Palatine Tonsil, Phenotype, Protein Tyrosine Phosphatase, Non-Receptor Type 6, Receptors, Antigen, B-Cell, Signal TransductionAdded July 13, 2015
14 MeSH Terms