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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 12

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Optimization of dosing for EGFR-mutant non-small cell lung cancer with evolutionary cancer modeling.
Chmielecki J, Foo J, Oxnard GR, Hutchinson K, Ohashi K, Somwar R, Wang L, Amato KR, Arcila M, Sos ML, Socci ND, Viale A, de Stanchina E, Ginsberg MS, Thomas RK, Kris MG, Inoue A, Ladanyi M, Miller VA, Michor F, Pao W
(2011) Sci Transl Med 3: 90ra59
MeSH Terms: Animals, Antineoplastic Agents, Carcinoma, Non-Small-Cell Lung, Cell Line, Tumor, Drug Resistance, Neoplasm, ErbB Receptors, Erlotinib Hydrochloride, Evolution, Molecular, Female, Gefitinib, Genes, erbB-1, Humans, Mice, Mice, Nude, Models, Theoretical, Mutation, Neoplasm Transplantation, Protein Kinase Inhibitors, Quinazolines
Added March 24, 2014
0 Communities
1 Members
0 Resources
19 MeSH Terms
Molecular characteristics predict clinical outcomes: prospective trial correlating response to the EGFR tyrosine kinase inhibitor gefitinib with the presence of sensitizing mutations in the tyrosine binding domain of the EGFR gene.
Rizvi NA, Rusch V, Pao W, Chaft JE, Ladanyi M, Miller VA, Krug LM, Azzoli CG, Bains M, Downey R, Flores R, Park B, Singh B, Zakowski M, Heelan RT, Shen R, Kris MG
(2011) Clin Cancer Res 17: 3500-6
MeSH Terms: Adult, Aged, Aged, 80 and over, Carcinoma, Non-Small-Cell Lung, Catalytic Domain, Drug Resistance, Neoplasm, ErbB Receptors, Female, Gefitinib, Genes, erbB-1, Humans, Lung Neoplasms, Male, Middle Aged, Mutation, Prognosis, Protein Binding, Protein Kinase Inhibitors, Quinazolines, Survival Analysis, Treatment Outcome, Tyrosine
Added March 24, 2014
0 Communities
1 Members
0 Resources
22 MeSH Terms
FAS and NF-κB signalling modulate dependence of lung cancers on mutant EGFR.
Bivona TG, Hieronymus H, Parker J, Chang K, Taron M, Rosell R, Moonsamy P, Dahlman K, Miller VA, Costa C, Hannon G, Sawyers CL
(2011) Nature 471: 523-6
MeSH Terms: Cell Line, Tumor, Dose-Response Relationship, Drug, Down-Regulation, Drug Resistance, Neoplasm, ErbB Receptors, Erlotinib Hydrochloride, Genes, erbB-1, Humans, I-kappa B Proteins, Lung Neoplasms, Models, Biological, Mutant Proteins, Mutation, NF-kappa B, Quinazolines, RNA Interference, Signal Transduction, fas Receptor
Added May 27, 2014
0 Communities
1 Members
0 Resources
18 MeSH Terms
NFKBIA deletion in glioblastomas.
Bredel M, Scholtens DM, Yadav AK, Alvarez AA, Renfrow JJ, Chandler JP, Yu IL, Carro MS, Dai F, Tagge MJ, Ferrarese R, Bredel C, Phillips HS, Lukac PJ, Robe PA, Weyerbrock A, Vogel H, Dubner S, Mobley B, He X, Scheck AC, Sikic BI, Aldape KD, Chakravarti A, Harsh GR
(2011) N Engl J Med 364: 627-37
MeSH Terms: DNA Mutational Analysis, Gene Amplification, Gene Deletion, Gene Expression, Genes, erbB-1, Glioblastoma, Humans, I-kappa B Proteins, Kaplan-Meier Estimate, NF-KappaB Inhibitor alpha, Prognosis, Tumor Cells, Cultured
Added August 14, 2014
0 Communities
1 Members
0 Resources
12 MeSH Terms
Analysis of genetic variants in never-smokers with lung cancer facilitated by an Internet-based blood collection protocol: a preliminary report.
Girard N, Lou E, Azzoli CG, Reddy R, Robson M, Harlan M, Orlow I, Yatabe Y, Nafa K, Ladanyi M, Viale A, Kris MG, Riely G, Miller V, Klein RJ, Matsuo K, Pao W
(2010) Clin Cancer Res 16: 755-63
MeSH Terms: Aged, Algorithms, Blood Specimen Collection, Carcinoma, Non-Small-Cell Lung, Case-Control Studies, DNA Mutational Analysis, Female, Gene Frequency, Genes, erbB-1, Geography, Humans, Internet, Lung Neoplasms, Male, Middle Aged, Pedigree, Polymorphism, Single Nucleotide, Retrospective Studies, Smoking, United States
Added March 24, 2014
0 Communities
1 Members
0 Resources
20 MeSH Terms
Clinical definition of acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors in non-small-cell lung cancer.
Jackman D, Pao W, Riely GJ, Engelman JA, Kris MG, Jänne PA, Lynch T, Johnson BE, Miller VA
(2010) J Clin Oncol 28: 357-60
MeSH Terms: Carcinoma, Non-Small-Cell Lung, Disease-Free Survival, Drug Resistance, Neoplasm, ErbB Receptors, Erlotinib Hydrochloride, Gefitinib, Genes, erbB-1, Guidelines as Topic, Humans, Lung Neoplasms, Mutation, Protein Kinase Inhibitors, Quinazolines
Added March 7, 2014
0 Communities
1 Members
0 Resources
13 MeSH Terms
Specific EGFR mutations predict treatment outcome of stage IIIB/IV patients with chemotherapy-naive non-small-cell lung cancer receiving first-line gefitinib monotherapy.
Yang CH, Yu CJ, Shih JY, Chang YC, Hu FC, Tsai MC, Chen KY, Lin ZZ, Huang CJ, Shun CT, Huang CL, Bean J, Cheng AL, Pao W, Yang PC
(2008) J Clin Oncol 26: 2745-53
MeSH Terms: Adult, Aged, Antineoplastic Agents, Carcinoma, Non-Small-Cell Lung, Female, Gefitinib, Gene Deletion, Genes, erbB-1, Genes, ras, Humans, Lung Neoplasms, Male, Middle Aged, Mutation, Predictive Value of Tests, Quinazolines, Survival Analysis
Added March 24, 2014
0 Communities
1 Members
0 Resources
17 MeSH Terms
EGFR mutations in lung adenocarcinomas: clinical testing experience and relationship to EGFR gene copy number and immunohistochemical expression.
Li AR, Chitale D, Riely GJ, Pao W, Miller VA, Zakowski MF, Rusch V, Kris MG, Ladanyi M
(2008) J Mol Diagn 10: 242-8
MeSH Terms: Adenocarcinoma, DNA Mutational Analysis, ErbB Receptors, Gene Amplification, Genes, erbB-1, Humans, In Situ Hybridization, Lung Neoplasms, Mutation, Tissue Array Analysis
Added March 24, 2014
0 Communities
1 Members
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10 MeSH Terms
Molecularly tailored adjuvant chemotherapy for resected non-small cell lung cancer: a time for excitement and equipoise.
Azzoli CG, Park BJ, Pao W, Zakowski M, Kris MG
(2008) J Thorac Oncol 3: 84-93
MeSH Terms: Antineoplastic Agents, Biomarkers, Tumor, Carcinoma, Non-Small-Cell Lung, Chemotherapy, Adjuvant, Cisplatin, Clinical Trials as Topic, Cyclin-Dependent Kinase Inhibitor p27, DNA-Binding Proteins, Endonucleases, Follow-Up Studies, Genes, erbB-1, Humans, Intracellular Signaling Peptides and Proteins, Lung Neoplasms, Membrane Transport Proteins, Multidrug Resistance-Associated Proteins, Neoplasm Staging, Proto-Oncogene Proteins, Proto-Oncogene Proteins p21(ras), Randomized Controlled Trials as Topic, Survival Analysis, Time Factors, Treatment Outcome, Tubulin, ras Proteins
Added March 24, 2014
0 Communities
1 Members
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25 MeSH Terms
The functional interplay between EGFR overexpression, hTERT activation, and p53 mutation in esophageal epithelial cells with activation of stromal fibroblasts induces tumor development, invasion, and differentiation.
Okawa T, Michaylira CZ, Kalabis J, Stairs DB, Nakagawa H, Andl CD, Johnstone CN, Klein-Szanto AJ, El-Deiry WS, Cukierman E, Herlyn M, Rustgi AK
(2007) Genes Dev 21: 2788-803
MeSH Terms: Animals, Cell Transformation, Neoplastic, Epithelial Cells, Esophageal Neoplasms, Esophagus, Female, Gene Expression Regulation, Neoplastic, Genes, erbB-1, Genes, p53, Humans, Mice, Mice, Nude, Mutation, Neoplasm Invasiveness, Neoplasms, Squamous Cell, Stromal Cells, Telomerase, Tumor Cells, Cultured
Added March 10, 2014
0 Communities
1 Members
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18 MeSH Terms