The myeloid immune signature of enterotoxigenic Bacteroides fragilis-induced murine colon tumorigenesis.
Thiele Orberg E, Fan H, Tam AJ, Dejea CM, Destefano Shields CE, Wu S, Chung L, Finard BB, Wu X, Fathi P, Ganguly S, Fu J, Pardoll DM, Sears CL, Housseau F
(2017) Mucosal Immunol 10
: 421-433MeSH Terms: Animals, Arginase, Bacterial Toxins, Bacteroides Infections, Bacteroides fragilis, Carcinogenesis, Cell Differentiation, Cell Proliferation, Cells, Cultured, Colon, Colorectal Neoplasms, Disease Models, Animal, Epithelial Cells, Genes, APC, Humans, Immune Tolerance, Interleukin-17, Metalloendopeptidases, Mice, Mice, Inbred C57BL, Mice, Mutant Strains, Myeloid-Derived Suppressor Cells, Nitric Oxide Synthase Type II, T-Lymphocytes, TranscriptomeAdded March 20, 2018
25 MeSH Terms
Advanced Intestinal Cancers often Maintain a Multi-Ancestral Architecture.
Zahm CD, Szulczewski JM, Leystra AA, Paul Olson TJ, Clipson L, Albrecht DM, Middlebrooks M, Thliveris AT, Matkowskyj KA, Washington MK, Newton MA, Eliceiri KW, Halberg RB
(2016) PLoS One 11
: e0150170MeSH Terms: Adenocarcinoma, Adenoma, Animals, Carcinoma in Situ, Cell Lineage, Cell Transformation, Neoplastic, Clone Cells, Disease Models, Animal, Disease Progression, Evolution, Molecular, Fatty Acid-Binding Proteins, Female, Gene Expression Regulation, Neoplastic, Genes, APC, Genes, Reporter, Integrases, Intestinal Mucosa, Intestinal Neoplasms, Luminescent Proteins, Male, Mice, Mice, Inbred C57BL, Models, Biological, Mosaicism, Neoplasm Invasiveness, Neoplastic Stem Cells, RNA, Untranslated, Rats, Transgenes, Tumor MicroenvironmentAdded April 12, 2016
30 MeSH Terms
Olive oil prevents benzo(a)pyrene [B(a)P]-induced colon carcinogenesis through altered B(a)P metabolism and decreased oxidative damage in Apc(Min) mouse model.
Banks LD, Amoah P, Niaz MS, Washington MK, Adunyah SE, Ramesh A
(2016) J Nutr Biochem 28
: 37-50MeSH Terms: Animals, Benzo(a)pyrene, Carcinogens, Colonic Neoplasms, Disease Models, Animal, Genes, APC, Mice, Olive Oil, Oxidative StressAdded February 22, 2016
9 MeSH Terms
Inducible loss of one Apc allele in Lrig1-expressing progenitor cells results in multiple distal colonic tumors with features of familial adenomatous polyposis.
Powell AE, Vlacich G, Zhao ZY, McKinley ET, Washington MK, Manning HC, Coffey RJ
(2014) Am J Physiol Gastrointest Liver Physiol 307
: G16-23MeSH Terms: Adenomatous Polyposis Coli, Animals, Cell Transformation, Neoplastic, Colon, Colonoscopy, Disease Models, Animal, Genes, APC, Hypertrophy, Membrane Glycoproteins, Mice, Mice, Transgenic, Neoplastic Stem Cells, Nerve Tissue Proteins, Positron-Emission Tomography, Precancerous Conditions, Retinal Pigment Epithelium, Time FactorsAdded May 20, 2014
17 MeSH Terms
Transformation of epithelial cells through recruitment leads to polyclonal intestinal tumors.
Thliveris AT, Schwefel B, Clipson L, Plesh L, Zahm CD, Leystra AA, Washington MK, Sullivan R, Deming DA, Newton MA, Halberg RB
(2013) Proc Natl Acad Sci U S A 110
: 11523-8MeSH Terms: Animals, Cell Transformation, Neoplastic, Epithelial Cells, Genes, APC, Humans, Intestinal Neoplasms, Mice, Mice, Inbred C57BLAdded April 12, 2016
8 MeSH Terms
Epithelial-specific deletion of 11β-HSD2 hinders Apcmin/+ mouse tumorigenesis.
Jiang L, Yang S, Yin H, Fan X, Wang S, Yao B, Pozzi A, Chen X, Harris RC, Zhang MZ
(2013) Mol Cancer Res 11
: 1040-50MeSH Terms: 11-beta-Hydroxysteroid Dehydrogenase Type 2, Adenoma, Animals, Carcinogenesis, Cell Cycle, Cell Line, Tumor, Colonic Neoplasms, Corticosterone, Cyclin-Dependent Kinase Inhibitor p21, Cyclooxygenase 2, Disease Models, Animal, Gene Expression Regulation, Neoplastic, Genes, APC, Humans, Intestinal Mucosa, Mice, Mice, Inbred C57BL, Sequence Deletion, TOR Serine-Threonine Kinases, Transcription Factors, Tumor Suppressor Protein p53Added February 26, 2014
21 MeSH Terms
Smad4-mediated signaling inhibits intestinal neoplasia by inhibiting expression of β-catenin.
Freeman TJ, Smith JJ, Chen X, Washington MK, Roland JT, Means AL, Eschrich SA, Yeatman TJ, Deane NG, Beauchamp RD
(2012) Gastroenterology 142
: 562-571.e2MeSH Terms: Adenocarcinoma, Adenomatous Polyposis Coli, Aged, Animals, Binding Sites, Bone Morphogenetic Proteins, Colorectal Neoplasms, Down-Regulation, Female, Genes, APC, HCT116 Cells, HEK293 Cells, Humans, Laser Capture Microdissection, Male, Mice, Mice, Knockout, Mice, Transgenic, Middle Aged, Oligonucleotide Array Sequence Analysis, RNA Polymerase II, RNA, Messenger, Smad4 Protein, Wnt Signaling Pathway, beta CateninAdded July 19, 2013
25 MeSH Terms
Proteomic consequences of a single gene mutation in a colorectal cancer model.
Halvey PJ, Zhang B, Coffey RJ, Liebler DC, Slebos RJ
(2012) J Proteome Res 11
: 1184-95MeSH Terms: Cell Line, Tumor, Cluster Analysis, Colorectal Neoplasms, Cytoplasm, Genes, APC, Humans, Models, Genetic, Mutation, Peptide Mapping, Proteome, Proteomics, Reproducibility of Results, Signal Transduction, Tandem Mass SpectrometryAdded March 12, 2014
14 MeSH Terms
Dietary fat-influenced development of colon neoplasia in Apc Min mice exposed to benzo(a)pyrene.
Harris DL, Washington MK, Hood DB, Roberts LJ, Ramesh A
(2009) Toxicol Pathol 37
: 938-46MeSH Terms: Animals, Benzo(a)pyrene, Body Weight, Carcinogens, Colon, Colonic Neoplasms, Colonic Polyps, Dietary Fats, Eating, Genes, APC, Male, Mice, Models, Animal, Organ SizeAdded April 12, 2016
14 MeSH Terms
Inhibition of 11beta-hydroxysteroid dehydrogenase type II selectively blocks the tumor COX-2 pathway and suppresses colon carcinogenesis in mice and humans.
Zhang MZ, Xu J, Yao B, Yin H, Cai Q, Shrubsole MJ, Chen X, Kon V, Zheng W, Pozzi A, Harris RC
(2009) J Clin Invest 119
: 876-85MeSH Terms: 11-beta-Hydroxysteroid Dehydrogenase Type 2, Adenocarcinoma, Adenoma, Animals, Base Sequence, Cell Line, Tumor, Colonic Neoplasms, Cyclooxygenase 2, Cyclooxygenase 2 Inhibitors, Enzyme Inhibitors, Gene Silencing, Genes, APC, Glycyrrhizic Acid, Humans, Male, Mice, Mice, Inbred BALB C, Mice, Mutant Strains, Models, Biological, Neovascularization, Pathologic, RNA, Small Interfering, Receptors, GlucocorticoidAdded February 24, 2014
22 MeSH Terms