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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 103

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CRISPR/Cas9 engineering of a KIM-1 reporter human proximal tubule cell line.
Veach RA, Wilson MH
(2018) PLoS One 13: e0204487
MeSH Terms: Acute Kidney Injury, CRISPR-Cas Systems, Cell Line, Cisplatin, Gene Knock-In Techniques, Gene Targeting, Genes, Reporter, Genetic Engineering, Glucose, Green Fluorescent Proteins, Hepatitis A Virus Cellular Receptor 1, Homologous Recombination, Humans, Kidney Tubules, Proximal, Luciferases, Up-Regulation
Added December 13, 2018
0 Communities
1 Members
0 Resources
16 MeSH Terms
Intrinsic apoptotic pathway activation increases response to anti-estrogens in luminal breast cancers.
Williams MM, Lee L, Werfel T, Joly MMM, Hicks DJ, Rahman B, Elion D, McKernan C, Sanchez V, Estrada MV, Massarweh S, Elledge R, Duvall C, Cook RS
(2018) Cell Death Dis 9: 21
MeSH Terms: Aniline Compounds, Animals, Apoptosis, Breast Neoplasms, Cell Line, Tumor, Down-Regulation, Estrogen Antagonists, Female, Fulvestrant, Gene Targeting, Humans, Mice, Myeloid Cell Leukemia Sequence 1 Protein, Receptors, Estrogen, Signal Transduction, Sulfonamides, Up-Regulation, bcl-X Protein
Added March 14, 2018
0 Communities
2 Members
0 Resources
18 MeSH Terms
Comparative analysis of chimeric ZFP-, TALE- and Cas9-piggyBac transposases for integration into a single locus in human cells.
Luo W, Galvan DL, Woodard LE, Dorset D, Levy S, Wilson MH
(2017) Nucleic Acids Res 45: 8411-8422
MeSH Terms: Bacterial Proteins, CRISPR-Associated Protein 9, CRISPR-Cas Systems, Cell Line, Tumor, DNA Transposable Elements, Endonucleases, Gene Knockout Techniques, Gene Targeting, Gene Transfer Techniques, Humans, Hypoxanthine Phosphoribosyltransferase, Mutagenesis, Insertional, Recombinant Fusion Proteins, Reproducibility of Results, Transcription Activator-Like Effector Nucleases, Transcription Activator-Like Effectors, Transposases, Zinc Fingers
Added September 11, 2017
0 Communities
2 Members
0 Resources
18 MeSH Terms
Generation of Targeted Mutations in Zebrafish Using the CRISPR/Cas System.
Yin L, Jao LE, Chen W
(2015) Methods Mol Biol 1332: 205-17
MeSH Terms: Animals, Animals, Genetically Modified, CRISPR-Cas Systems, Gene Targeting, Mutagenesis, Site-Directed, Mutation, RNA Editing, RNA, Guide, RNA, Messenger, Zebrafish
Added February 15, 2016
0 Communities
1 Members
0 Resources
10 MeSH Terms
High-throughput gene targeting and phenotyping in zebrafish using CRISPR/Cas9.
Varshney GK, Pei W, LaFave MC, Idol J, Xu L, Gallardo V, Carrington B, Bishop K, Jones M, Li M, Harper U, Huang SC, Prakash A, Chen W, Sood R, Ledin J, Burgess SM
(2015) Genome Res 25: 1030-42
MeSH Terms: Alleles, Animals, CRISPR-Cas Systems, Gene Knockout Techniques, Gene Targeting, Genome-Wide Association Study, Genomics, Germ Cells, High-Throughput Screening Assays, Humans, Mutagenesis, Phenotype, Quantitative Trait Loci, RNA, Guide, Sequence Deletion, Zebrafish
Added July 23, 2015
0 Communities
1 Members
0 Resources
16 MeSH Terms
Multiplex Conditional Mutagenesis Using Transgenic Expression of Cas9 and sgRNAs.
Yin L, Maddison LA, Li M, Kara N, LaFave MC, Varshney GK, Burgess SM, Patton JG, Chen W
(2015) Genetics 200: 431-41
MeSH Terms: Animals, Animals, Genetically Modified, CRISPR-Cas Systems, Gene Expression, Gene Order, Gene Silencing, Gene Targeting, Genetic Vectors, Glucose, Hypopigmentation, Mutagenesis, Phenotype, RNA, Guide, Transgenes, Zebrafish
Added July 23, 2015
0 Communities
2 Members
0 Resources
15 MeSH Terms
Activity-dependent FMRP requirements in development of the neural circuitry of learning and memory.
Doll CA, Broadie K
(2015) Development 142: 1346-56
MeSH Terms: Animals, Dendrites, Drosophila Proteins, Drosophila melanogaster, Fragile X Mental Retardation Protein, Gene Knockdown Techniques, Gene Targeting, Memory, Mushroom Bodies, Mutation, Nerve Net, Time Factors
Added March 29, 2017
1 Communities
1 Members
0 Resources
12 MeSH Terms
Targeting piggyBac transposon integrations in the human genome.
Galvan DL, Kettlun CS, Wilson MH
(2014) Methods Mol Biol 1114: 143-61
MeSH Terms: DNA Transposable Elements, Gene Order, Gene Targeting, Genetic Vectors, Genome, Human, HEK293 Cells, Homologous Recombination, Humans, Mutagenesis, Insertional
Added March 6, 2014
0 Communities
1 Members
0 Resources
9 MeSH Terms
Generation of Nkx2.2:lacZ mice using recombination-mediated cassette exchange technology.
Arnes L, Leclerc K, Friel JM, Hipkens SB, Magnuson MA, Sussel L
(2012) Genesis 50: 612-24
MeSH Terms: Animals, Central Nervous System, Gene Expression Regulation, Developmental, Gene Order, Gene Targeting, Genotype, Homeodomain Proteins, Homologous Recombination, Mice, Mice, Transgenic, Neural Stem Cells, Pancreas, Phenotype, Transcription Factors, Zebrafish Proteins, beta-Galactosidase
Added October 19, 2012
2 Communities
1 Members
1 Resources
16 MeSH Terms
Generation of a conditional allele for the mouse endothelial nitric oxide synthase gene.
Jiang R, Wang S, Takahashi K, Fujita H, Fruci CR, Breyer MD, Harris RC, Takahashi T
(2012) Genesis 50: 685-92
MeSH Terms: Alleles, Animals, Blood Pressure, Embryonic Stem Cells, Endothelium, Exons, Female, Gene Deletion, Gene Targeting, Genetic Engineering, Heart Rate, Homozygote, Hypertension, Integrases, Kidney, Lung, Male, Mice, Mice, Inbred C57BL, Mice, Knockout, Models, Animal, Nitric Oxide, Nitric Oxide Synthase Type III, Phenotype, Recombination, Genetic
Added August 27, 2013
2 Communities
2 Members
0 Resources
25 MeSH Terms