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Multilayer modelling of the human transcriptome and biological mechanisms of complex diseases and traits.
Azevedo T, Dimitri GM, Lió P, Gamazon ER
(2021) NPJ Syst Biol Appl 7: 24
MeSH Terms: Gene Regulatory Networks, Genomics, Humans, Organ Specificity, Phenotype, Transcriptome
Added May 30, 2021
0 Communities
1 Members
0 Resources
6 MeSH Terms
An integrative systems-based analysis of substance use: eQTL-informed gene-based tests, gene networks, and biological mechanisms.
Gerring ZF, Vargas AM, Gamazon ER, Derks EM
(2021) Am J Med Genet B Neuropsychiatr Genet 186: 162-172
MeSH Terms: Gene Expression Profiling, Gene Regulatory Networks, Genetic Predisposition to Disease, Genetic Testing, Genome-Wide Association Study, Humans, Phenotype, Polymorphism, Single Nucleotide, Quantitative Trait Loci, Substance-Related Disorders
Added December 30, 2020
0 Communities
1 Members
0 Resources
10 MeSH Terms
Gene network transitions in embryos depend upon interactions between a pioneer transcription factor and core histones.
Iwafuchi M, Cuesta I, Donahue G, Takenaka N, Osipovich AB, Magnuson MA, Roder H, Seeholzer SH, Santisteban P, Zaret KS
(2020) Nat Genet 52: 418-427
MeSH Terms: Amino Acid Sequence, Animals, Cell Line, Chromatin, DNA, Female, Gene Expression Regulation, Developmental, Gene Regulatory Networks, Histones, Humans, Mice, Mice, Inbred C57BL, Nucleosomes, Transcription Factors, Transcription, Genetic
Added April 7, 2020
1 Communities
3 Members
0 Resources
15 MeSH Terms
Long non-coding RNA enhances chondrogenesis via suppression of the interferon type II signaling pathway.
Huynh NP, Gloss CC, Lorentz J, Tang R, Brunger JM, McAlinden A, Zhang B, Guilak F
(2020) Elife 9:
MeSH Terms: Binding Sites, Cell Differentiation, Cells, Cultured, Chondrocytes, Chondrogenesis, Extracellular Matrix, Gene Editing, Gene Expression Profiling, Gene Expression Regulation, Developmental, Gene Regulatory Networks, Humans, Immunohistochemistry, Interferon-gamma, Mesenchymal Stem Cells, Protein Binding, RNA, Long Noncoding, Signal Transduction
Added March 16, 2021
0 Communities
1 Members
0 Resources
17 MeSH Terms
Systems-level network modeling of Small Cell Lung Cancer subtypes identifies master regulators and destabilizers.
Wooten DJ, Groves SM, Tyson DR, Liu Q, Lim JS, Albert R, Lopez CF, Sage J, Quaranta V
(2019) PLoS Comput Biol 15: e1007343
MeSH Terms: Algorithms, Animals, Basic Helix-Loop-Helix Transcription Factors, Bayes Theorem, Cell Line, Tumor, Cluster Analysis, Databases, Genetic, Drug Resistance, Neoplasm, Gene Expression, Gene Expression Regulation, Neoplastic, Gene Ontology, Gene Regulatory Networks, Humans, Mice, Models, Theoretical, Small Cell Lung Carcinoma, Systems Analysis, Transcription Factors
Added March 30, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
Histone deacetylase 3 controls a transcriptional network required for B cell maturation.
Stengel KR, Bhaskara S, Wang J, Liu Q, Ellis JD, Sampathi S, Hiebert SW
(2019) Nucleic Acids Res 47: 10612-10627
MeSH Terms: Animals, Antigens, CD19, B-Lymphocytes, Base Sequence, Cell Differentiation, Gene Expression Regulation, Gene Regulatory Networks, Histone Deacetylase Inhibitors, Histone Deacetylases, Lipopolysaccharides, Lymphocyte Activation, Mice, Inbred C57BL, Plasma Cells, Positive Regulatory Domain I-Binding Factor 1, Proto-Oncogene Proteins c-bcl-6, Repressor Proteins, Transcription, Genetic, Up-Regulation
Added October 25, 2019
1 Communities
0 Members
0 Resources
18 MeSH Terms
A gene co-expression network-based analysis of multiple brain tissues reveals novel genes and molecular pathways underlying major depression.
Gerring ZF, Gamazon ER, Derks EM, Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium
(2019) PLoS Genet 15: e1008245
MeSH Terms: Brain Chemistry, Complement C4a, Depressive Disorder, Major, Gene Expression Profiling, Gene Expression Regulation, Gene Regulatory Networks, Genome-Wide Association Study, Humans, Organ Specificity, Quantitative Trait Loci, Sequence Analysis, RNA
Added July 17, 2019
0 Communities
1 Members
0 Resources
11 MeSH Terms
Multi-tissue transcriptome analyses identify genetic mechanisms underlying neuropsychiatric traits.
Gamazon ER, Zwinderman AH, Cox NJ, Denys D, Derks EM
(2019) Nat Genet 51: 933-940
MeSH Terms: Algorithms, Computational Biology, Gene Expression Profiling, Gene Expression Regulation, Gene Regulatory Networks, Genetic Association Studies, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Mental Disorders, Organ Specificity, Polymorphism, Single Nucleotide, Quantitative Trait Loci, Quantitative Trait, Heritable, Transcriptome
Added July 17, 2019
0 Communities
1 Members
0 Resources
MeSH Terms
A Synthetic Gene Circuit for Self-Regulating Delivery of Biologic Drugs in Engineered Tissues.
Pferdehirt L, Ross AK, Brunger JM, Guilak F
(2019) Tissue Eng Part A 25: 809-820
MeSH Terms: Animals, Biological Products, Gene Regulatory Networks, Genes, Synthetic, Genetic Therapy, HEK293 Cells, Humans, Interleukin 1 Receptor Antagonist Protein, Interleukin-1alpha, Mice, Tissue Engineering
Added March 16, 2021
0 Communities
1 Members
0 Resources
MeSH Terms
Comparative Molecular Analysis of Gastrointestinal Adenocarcinomas.
Liu Y, Sethi NS, Hinoue T, Schneider BG, Cherniack AD, Sanchez-Vega F, Seoane JA, Farshidfar F, Bowlby R, Islam M, Kim J, Chatila W, Akbani R, Kanchi RS, Rabkin CS, Willis JE, Wang KK, McCall SJ, Mishra L, Ojesina AI, Bullman S, Pedamallu CS, Lazar AJ, Sakai R, Cancer Genome Atlas Research Network, Thorsson V, Bass AJ, Laird PW
(2018) Cancer Cell 33: 721-735.e8
MeSH Terms: Adenocarcinoma, Aneuploidy, Chromosomal Instability, DNA Methylation, DNA Polymerase II, DNA-Binding Proteins, Epigenesis, Genetic, Female, Gastrointestinal Neoplasms, Gene Regulatory Networks, Heterogeneous-Nuclear Ribonucleoproteins, Humans, Male, Microsatellite Instability, MutL Protein Homolog 1, Mutation, Poly-ADP-Ribose Binding Proteins, Polymorphism, Single Nucleotide, Proto-Oncogene Proteins p21(ras), RNA-Binding Proteins, SOX9 Transcription Factor
Added October 30, 2019
0 Communities
1 Members
0 Resources
21 MeSH Terms